TissGeneSummary for TXNDC2 |
Gene summary |
Basic gene information | Gene symbol | TXNDC2 |
Gene name | thioredoxin domain containing 2 (spermatozoa) | |
Synonyms | SPTRX|SPTRX1 | |
Cytomap | UCSC genome browser: - | |
Type of gene | protein-coding | |
RefGenes | NM_001098529.1, NM_032243.5, | |
Description | sperm-specific thioredoxin 1spermatid-specific thioredoxin-1sptrx-1thioredoxin domain-containing 2 (spermatozoa)thioredoxin domain-containing protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000168454 | ||
HPRD : 11654 | ||
Vega : OTTHUMG00000131602 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TXNDC2 | |
BioGPS: 84203 | ||
Pathway | NCI Pathway Interaction Database: TXNDC2 | |
KEGG: TXNDC2 | ||
REACTOME: TXNDC2 | ||
Pathway Commons: TXNDC2 | ||
Context | iHOP: TXNDC2 | |
ligand binding site mutation search in PubMed: TXNDC2 | ||
UCL Cancer Institute: TXNDC2 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TXNDC2 | Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. FEBS Lett. 2002 Oct 23;530(1-3):79-84. (pmid:12387870) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0055114 | oxidation-reduction process | 11399755 | GO:0055114 | oxidation-reduction process | 11399755 |
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TissGeneExp for TXNDC2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.71722134 | -1.939014363 | 1.221793023 | 5.94E-10 | 1.03E-08 |
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TissGene-miRNA for TXNDC2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TXNDC2 |
TissGeneSNV for TXNDC2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E200K | KIRC | 2 |
p.E21K | SKCM | 2 |
p.E245* | UCEC | 2 |
p.I314L | SARC | 2 |
p.G207D | SKCM | 2 |
p.S285P | ESCA | 1 |
p.Q368L | STAD | 1 |
p.P120S | SKCM | 1 |
p.G207S | SKCM | 1 |
p.P375L | SKCM | 1 |
p.P243S | SKCM | 1 |
p.T478M | LGG | 1 |
p.K140E | LGG | 1 |
p.R76H | LUSC | 1 |
p.L333P | THYM | 1 |
p.K140E | ACC | 1 |
p.I329L | ESCA | 1 |
p.V495L | SKCM | 1 |
p.E479K | BLCA | 1 |
p.S83L | CESC | 1 |
p.K226N | READ | 1 |
p.E365K | LGG | 1 |
p.T351A | UVM | 1 |
p.S93L | CESC | 1 |
p.T351P | LIHC | 1 |
p.E200K | PCPG | 1 |
p.K140E | TGCT | 1 |
p.E192D | LUSC | 1 |
p.P405S | BRCA | 1 |
p.N148D | TGCT | 1 |
p.K140E | GBM | 1 |
p.S362C | BLCA | 1 |
p.S242F | SKCM | 1 |
p.K220* | LIHC | 1 |
p.I157T | LIHC | 1 |
p.R76H | KIRC | 1 |
p.E349K | SKCM | 1 |
p.P180S | SKCM | 1 |
p.P279T | HNSC | 1 |
p.P90T | READ | 1 |
p.K226N | UCEC | 1 |
p.V69F | LUAD | 1 |
p.E350* | SKCM | 1 |
p.S92C | STAD | 1 |
p.E551K | UCEC | 1 |
p.A35V | DLBC | 1 |
p.L463M | BRCA | 1 |
p.K145I | LUAD | 1 |
p.I329L | BLCA | 1 |
p.K220X | LIHC | 1 |
p.W479X | SKCM | 1 |
p.K140E | UVM | 1 |
p.E200K | HNSC | 1 |
p.N148S | STAD | 1 |
p.K211N | UCEC | 1 |
p.D535N | SKCM | 1 |
p.L333P | UCEC | 1 |
p.P183Q | LUAD | 1 |
p.L470P | STAD | 1 |
p.E200K | KIRP | 1 |
p.L49F | BLCA | 1 |
p.G162D | LGG | 1 |
p.E281K | SKCM | 1 |
p.W479* | SKCM | 1 |
p.K140E | LUAD | 1 |
p.G387S | SKCM | 1 |
p.P183T | LUAD | 1 |
p.N148D | CHOL | 1 |
p.S147G | CHOL | 1 |
p.T227A | DLBC | 1 |
p.P405L | HNSC | 1 |
p.D458N | SKCM | 1 |
p.E350X | SKCM | 1 |
p.C538Y | PAAD | 1 |
p.L303P | UCEC | 1 |
p.D373E | ESCA | 1 |
p.P378S | SKCM | 1 |
p.R487T | COAD | 1 |
p.A225V | COAD | 1 |
p.D343G | STAD | 1 |
p.E6K | SKCM | 1 |
p.I202M | HNSC | 1 |
p.G25D | STAD | 1 |
p.R484K | SKCM | 1 |
p.P264T | LUAD | 1 |
p.T5K | BLCA | 1 |
p.E546K | BLCA | 1 |
p.E185* | UCEC | 1 |
p.E200K | GBM | 1 |
p.K226N | LUAD | 1 |
p.I382T | UCEC | 1 |
p.P204L | LUAD | 1 |
p.I314L | CHOL | 1 |
p.L470Q | LUAD | 1 |
p.T227A | THYM | 1 |
p.E32K | HNSC | 1 |
p.E296K | HNSC | 1 |
p.I402S | KIRP | 1 |
p.L40S | PAAD | 1 |
p.E320K | THCA | 1 |
p.S80Y | CESC | 1 |
p.I359T | PRAD | 1 |
p.E124K | SKCM | 1 |
p.D118E | CESC | 1 |
p.E109* | UCEC | 1 |
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TissGeneCNV for TXNDC2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TXNDC2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TXNDC2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TXNDC2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TXNDC2 |
TissGeneDrug for TXNDC2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TXNDC2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |