TissGeneSummary for MEX3B |
Gene summary |
Basic gene information | Gene symbol | MEX3B |
Gene name | mex-3 RNA binding family member B | |
Synonyms | MEX-3B|RKHD3|RNF195 | |
Cytomap | UCSC genome browser: 15q25.2 | |
Type of gene | protein-coding | |
RefGenes | NM_032246.4, | |
Description | RING finger protein 195RNA-binding protein MEX3Bring finger and KH domain containing 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611008 | |
HGNC : HGNC | ||
Ensembl : ENSG00000183496 | ||
HPRD : 15256 | ||
Vega : OTTHUMG00000147356 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MEX3B | |
BioGPS: 84206 | ||
Pathway | NCI Pathway Interaction Database: MEX3B | |
KEGG: MEX3B | ||
REACTOME: MEX3B | ||
Pathway Commons: MEX3B | ||
Context | iHOP: MEX3B | |
ligand binding site mutation search in PubMed: MEX3B | ||
UCL Cancer Institute: MEX3B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MEX3B | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MEX3B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -0.055526102 | -1.120044852 | 1.06451875 | 5.35E-07 | 2.89E-06 |
LUSC | 1.255242709 | -0.356310232 | 1.611552941 | 2.24E-13 | 1.11E-12 |
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TissGene-miRNA for MEX3B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-520d-3p | MIMAT0002856 | 0.0033 | -0.28 | 122 |
THYM | hsa-miR-520e | MIMAT0002825 | 0.0081 | -0.3 | 122 |
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TissGeneMut for MEX3B |
TissGeneSNV for MEX3B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R512H | UCEC | 1 |
p.A150T | COAD | 1 |
p.D287N | STAD | 1 |
p.A309S | LUAD | 1 |
p.M210I | KIRC | 1 |
p.S299C | COAD | 1 |
p.R185H | UCEC | 1 |
p.V392I | STAD | 1 |
p.P321S | SARC | 1 |
p.A344P | UCEC | 1 |
p.D247N | UCEC | 1 |
p.R512H | PRAD | 1 |
p.R566C | SKCM | 1 |
p.E553K | LUAD | 1 |
p.V248A | STAD | 1 |
p.K90N | LUAD | 1 |
p.I183M | CESC | 1 |
p.P365L | THYM | 1 |
p.R124Q | STAD | 1 |
p.L510I | UCEC | 1 |
p.R185H | COAD | 1 |
p.A328T | THYM | 1 |
p.G339R | SKCM | 1 |
p.A328V | LUAD | 1 |
p.R141Q | LIHC | 1 |
p.G303S | STAD | 1 |
p.P555Q | LIHC | 1 |
p.S506Y | BLCA | 1 |
p.G466* | ESCA | 1 |
p.G173R | BLCA | 1 |
p.A217S | LUAD | 1 |
p.T114M | PRAD | 1 |
p.S496L | SKCM | 1 |
p.V167L | LUAD | 1 |
p.P555L | STAD | 1 |
p.R218L | LUAD | 1 |
p.Y284C | KIRP | 1 |
p.P555R | HNSC | 1 |
p.S497C | ESCA | 1 |
p.P357H | STAD | 1 |
p.I127T | LIHC | 1 |
p.A121P | HNSC | 1 |
p.S282C | LUAD | 1 |
p.E358K | COAD | 1 |
p.G355S | STAD | 1 |
p.F281L | LUAD | 1 |
p.A560T | UCEC | 1 |
p.A475V | PAAD | 1 |
p.G149D | LIHC | 1 |
p.E68Q | CESC | 1 |
p.G304R | STAD | 1 |
p.T562I | STAD | 1 |
p.P444R | ACC | 1 |
p.S402P | LAML | 1 |
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TissGeneCNV for MEX3B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MEX3B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MEX3B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MEX3B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MEX3B |
TissGeneDrug for MEX3B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MEX3B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |