TissGeneSummary for NBPF3 |
Gene summary |
Basic gene information | Gene symbol | NBPF3 |
Gene name | neuroblastoma breakpoint family, member 3 | |
Synonyms | AE2 | |
Cytomap | UCSC genome browser: 1p36.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001256416.2, NM_001256417.2,NM_032264.4,NR_046176.2, | |
Description | neuroblastoma breakpoint family member 3protein SHIIIa4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612992 | |
HGNC : HGNC | ||
Ensembl : ENSG00000142794 | ||
HPRD : 10633 | ||
Vega : OTTHUMG00000002944 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NBPF3 | |
BioGPS: 84224 | ||
Pathway | NCI Pathway Interaction Database: NBPF3 | |
KEGG: NBPF3 | ||
REACTOME: NBPF3 | ||
Pathway Commons: NBPF3 | ||
Context | iHOP: NBPF3 | |
ligand binding site mutation search in PubMed: NBPF3 | ||
UCL Cancer Institute: NBPF3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NBPF3 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NBPF3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.232883257 | 0.028256743 | -1.26114 | 0.000128 | 0.000326141 |
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TissGene-miRNA for NBPF3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NBPF3 |
TissGeneSNV for NBPF3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F368C | PAAD | 4 |
p.D354A | LIHC | 2 |
p.E357G | LUAD | 2 |
p.R228K | BLCA | 1 |
p.S341C | BLCA | 1 |
p.D310V | LUAD | 1 |
p.D366V | LUAD | 1 |
p.Y114C | BRCA | 1 |
p.L127F | SKCM | 1 |
p.K64I | LUAD | 1 |
p.R41* | PAAD | 1 |
p.C457S | LIHC | 1 |
p.E357G | PRAD | 1 |
p.V603A | COAD | 1 |
p.E141D | LUSC | 1 |
p.E39* | UCEC | 1 |
p.H348Y | SKCM | 1 |
p.P433H | LUAD | 1 |
p.Q393E | CESC | 1 |
p.F368C | BLCA | 1 |
p.E469* | CESC | 1 |
p.E411K | SKCM | 1 |
p.Q40H | BLCA | 1 |
p.R36Q | COAD | 1 |
p.V464M | READ | 1 |
p.G9V | LUAD | 1 |
p.Y596H | CESC | 1 |
p.Q583E | CESC | 1 |
p.H156P | COAD | 1 |
p.A308T | STAD | 1 |
p.E413K | SKCM | 1 |
p.S25T | STAD | 1 |
p.Q114R | UVM | 1 |
p.H246N | BLCA | 1 |
p.E470K | PRAD | 1 |
p.S501L | UCEC | 1 |
p.E467D | UCEC | 1 |
p.S220Y | PRAD | 1 |
p.H302N | BLCA | 1 |
p.E357G | PAAD | 1 |
p.Q102E | BLCA | 1 |
p.K175Q | CESC | 1 |
p.K41X | PAAD | 1 |
p.Q46E | BLCA | 1 |
p.L246F | LIHC | 1 |
p.H213Q | OV | 1 |
p.A252V | LGG | 1 |
p.H100Y | SKCM | 1 |
p.G35D | LGG | 1 |
p.S475F | SKCM | 1 |
p.K240Q | LIHC | 1 |
p.L106P | BLCA | 1 |
p.Y114C | COAD | 1 |
p.G62S | STAD | 1 |
p.D118H | BLCA | 1 |
p.G22V | SKCM | 1 |
p.S289P | ESCA | 1 |
p.E413G | UCEC | 1 |
p.S22F | SKCM | 1 |
p.D291N | BLCA | 1 |
p.Q397K | SKCM | 1 |
p.Q96H | BLCA | 1 |
p.E413* | CESC | 1 |
p.L436* | SKCM | 1 |
p.A129V | SKCM | 1 |
p.R145Q | BLCA | 1 |
p.T147R | DLBC | 1 |
p.W12* | BLCA | 1 |
p.R104Q | SKCM | 1 |
p.G46S | THYM | 1 |
p.G25S | STAD | 1 |
p.G6S | BLCA | 1 |
p.C310Y | UCEC | 1 |
p.P183S | SKCM | 1 |
p.A341V | UCEC | 1 |
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TissGeneCNV for NBPF3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NBPF3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-AA7D-01A | NBPF3-NBPF15 | 5'UTR-5'UTR | chr1:21766841 | chr1:148560846 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-AASV-01A | NBPF3-NBPF15 | 5'UTR-5'UTR | chr1:21766841 | chr1:148560846 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49X-01A | NBPF3-NBPF15 | 5'UTR-5'UTR | chr1:21766841 | chr1:148560846 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49M-01A | NBPF3-NBPF15 | 5'UTR-5'UTR | chr1:21766841 | chr1:148560846 |
Chimerdb3.0 | FusionScan | OV | TCGA-OY-A56Q-01A | CROCC-NBPF3 | CDS-5'UTR | chr1:17265637 | chr1:21771440 |
TCGAfusionPortal | PRADA | GBM | TCGA-28-2513-01A | NBPF3-EPHB2 | 5UTR-CDS | Chr1:21771712 | Chr1:23189530 |
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TissGeneNet for NBPF3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NBPF3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NBPF3 |
TissGeneDrug for NBPF3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NBPF3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1561546 | Alkaline Phosphatase Adverse Event | 2 | GAD |
umls:C0023895 | Liver diseases | 1 | BeFree |