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| TissGeneSummary for ZNF282 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF282 |
| Gene name | zinc finger protein 282 | |
| Synonyms | HUB1 | |
| Cytomap | UCSC genome browser: 7q36.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003575.2, | |
| Description | HTLV-I U5 repressive element-binding protein 1HTLV-I U5RE-binding protein 1HUB-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603397 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170265 | ||
| HPRD : 04549 | ||
| Vega : OTTHUMG00000158974 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF282 | |
| BioGPS: 8427 | ||
| Pathway | NCI Pathway Interaction Database: ZNF282 | |
| KEGG: ZNF282 | ||
| REACTOME: ZNF282 | ||
| Pathway Commons: ZNF282 | ||
| Context | iHOP: ZNF282 | |
| ligand binding site mutation search in PubMed: ZNF282 | ||
| UCL Cancer Institute: ZNF282 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCPRAD | |
| Reference showing the relevant tissue of ZNF282 | ||
| Description by TissGene annotations | TissgsLTS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF282 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZNF282 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF282 |
| TissGeneSNV for ZNF282 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q90L | LIHC | 1 |
| p.I321V | COAD | 1 |
| p.I316V | LIHC | 1 |
| p.D381Y | UCEC | 1 |
| p.P186H | LUAD | 1 |
| p.T351M | LGG | 1 |
| p.E109K | LUAD | 1 |
| p.V227A | STAD | 1 |
| p.E634K | BLCA | 1 |
| p.V153M | BRCA | 1 |
| p.V182G | OV | 1 |
| p.R87* | ESCA | 1 |
| p.D135N | BLCA | 1 |
| p.V108M | BLCA | 1 |
| p.R329Q | GBM | 1 |
| p.C548F | SARC | 1 |
| p.R670Q | READ | 1 |
| p.R640H | STAD | 1 |
| p.G512C | BLCA | 1 |
| p.P187L | BLCA | 1 |
| p.G633S | UCEC | 1 |
| p.S328F | HNSC | 1 |
| p.D346N | HNSC | 1 |
| p.M61I | OV | 1 |
| p.M67L | LIHC | 1 |
| p.R538C | LUAD | 1 |
| p.R514H | LUAD | 1 |
| p.P665L | SKCM | 1 |
| p.E148K | SKCM | 1 |
| p.G570V | SARC | 1 |
| p.S539N | GBM | 1 |
| p.H558Y | PRAD | 1 |
| p.R380H | STAD | 1 |
| p.T597M | LUAD | 1 |
| p.N591K | BLCA | 1 |
| p.I96T | COAD | 1 |
| p.G636V | COAD | 1 |
| p.S149N | LUSC | 1 |
| p.R304W | HNSC | 1 |
| p.N616D | BRCA | 1 |
| p.A134D | UCEC | 1 |
| p.E229D | READ | 1 |
| p.G155W | UCS | 1 |
| p.E211* | HNSC | 1 |
| p.T139M | STAD | 1 |
| p.G493D | MESO | 1 |
| p.T6K | KIRP | 1 |
| p.Y223D | UCEC | 1 |
| p.R380H | LUAD | 1 |
| p.S559T | LUAD | 1 |
| p.R166K | HNSC | 1 |
| p.R166K | SKCM | 1 |
| p.I349N | STAD | 1 |
| p.G570S | STAD | 1 |
| p.R184Q | UCEC | 1 |
| p.E522K | STAD | 1 |
| p.G385R | LGG | 1 |
| p.C557Y | STAD | 1 |
| p.G598A | LUSC | 1 |
| p.S357C | LUSC | 1 |
| p.Q12K | ACC | 1 |
| p.S577L | UCEC | 1 |
| p.H592Y | READ | 1 |
| p.R87Q | HNSC | 1 |
| p.R506Q | PAAD | 1 |
| p.V102M | LUAD | 1 |
| p.R87X | ESCA | 1 |
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| TissGeneCNV for ZNF282 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF282 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA513395 | ZNF276-ZNF282 | chr16:89806250 | chr7:148922515 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JK-01A | ZNF282-CUL1 | Out-of-frame | Chr7:148910906 | Chr7:148463653 |
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| TissGeneNet for ZNF282 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| KICH (tumor) | KICH (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (tumor) | ZNF282, PIK3CG, SUMO2, MAPKAPK5, PKN1 (normal) |
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| TissGeneProg for ZNF282 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF282 |
| TissGeneDrug for ZNF282 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF282 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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