TissGeneSummary for NR0B2 |
Gene summary |
Basic gene information | Gene symbol | NR0B2 |
Gene name | nuclear receptor subfamily 0, group B, member 2 | |
Synonyms | SHP|SHP1 | |
Cytomap | UCSC genome browser: 1p36.1 | |
Type of gene | protein-coding | |
RefGenes | NM_021969.2, | |
Description | nuclear receptor SHPnuclear receptor subfamily 0 group B member 2orphan nuclear receptor SHPsmall heterodimer partner | |
Modification date | 20141207 | |
dbXrefs | MIM : 604630 | |
HGNC : HGNC | ||
Ensembl : ENSG00000131910 | ||
HPRD : 05219 | ||
Vega : OTTHUMG00000004231 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NR0B2 | |
BioGPS: 8431 | ||
Pathway | NCI Pathway Interaction Database: NR0B2 | |
KEGG: NR0B2 | ||
REACTOME: NR0B2 | ||
Pathway Commons: NR0B2 | ||
Context | iHOP: NR0B2 | |
ligand binding site mutation search in PubMed: NR0B2 | ||
UCL Cancer Institute: NR0B2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of NR0B2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 14752053 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 14752053 |
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TissGeneExp for NR0B2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 7.986621025 | 9.767013025 | -1.780392 | 1.22E-06 | 6.42E-06 |
KIRC | -0.85766042 | 5.942422913 | -6.800083333 | 7.11E-47 | 4.83E-45 |
LUAD | 1.853640059 | 4.809905576 | -2.956265517 | 4.30E-12 | 3.16E-11 |
LUSC | -0.313535093 | 4.616615887 | -4.93015098 | 6.93E-28 | 2.23E-26 |
KIRP | -0.41392535 | 6.282365275 | -6.696290625 | 2.46E-19 | 1.35E-17 |
KICH | 8.020959025 | 6.594971025 | 1.425988 | 0.00649 | 0.012142581 |
COAD | 3.460016717 | 1.688678255 | 1.771338462 | 0.000157 | 0.000544283 |
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TissGene-miRNA for NR0B2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NR0B2 |
TissGeneSNV for NR0B2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L218V | LIHC | 1 |
p.P228L | STAD | 1 |
p.L98I | LIHC | 1 |
p.L98F | UCEC | 1 |
p.A210S | PCPG | 1 |
p.R38H | LUAD | 1 |
p.H53D | BRCA | 1 |
p.E165K | SKCM | 1 |
p.V67M | LUSC | 1 |
p.G7E | SKCM | 1 |
p.L218F | BLCA | 1 |
p.A31T | LIHC | 1 |
p.E204K | SKCM | 1 |
p.R36C | BLCA | 1 |
p.P80S | LUAD | 1 |
p.W197* | LUAD | 1 |
p.P35S | HNSC | 1 |
p.P46L | SKCM | 1 |
p.R85W | UCEC | 1 |
p.R86W | GBM | 1 |
p.Q150* | SKCM | 1 |
p.D234N | SKCM | 1 |
p.G189R | SKCM | 1 |
p.P239S | SKCM | 1 |
p.R45W | ESCA | 1 |
p.A64S | LIHC | 1 |
p.A68T | STAD | 1 |
p.R216H | BRCA | 1 |
p.F107L | SKCM | 1 |
p.R238H | STAD | 1 |
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TissGeneCNV for NR0B2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NR0B2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NR0B2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NR0B2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NR0B2 |
TissGeneDrug for NR0B2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NR0B2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 13 | BeFree,CTD_human |
umls:C0011849 | Diabetes Mellitus | 9 | BeFree,RGD |
umls:C0028754 | Obesity | 9 | BeFree,CTD_human,GAD |
umls:C0006142 | Malignant neoplasm of breast | 8 | BeFree |
umls:C0011847 | Diabetes | 8 | BeFree |
umls:C0024299 | Lymphoma | 8 | BeFree |
umls:C0678222 | Breast Carcinoma | 8 | BeFree |
umls:C0023418 | leukemia | 6 | BeFree |
umls:C0023473 | Myeloid Leukemia, Chronic | 6 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 4 | BeFree |
umls:C0023903 | Liver neoplasms | 4 | BeFree |
umls:C0026769 | Multiple Sclerosis | 4 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,GAD |
umls:C0023794 | Lipoidosis | 3 | CTD_human |
umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
umls:C0025517 | Metabolic Diseases | 3 | BeFree |
umls:C0026764 | Multiple Myeloma | 3 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 3 | BeFree |
umls:C0239946 | Fibrosis, Liver | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0004096 | Asthma | 2 | BeFree |
umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0019163 | Hepatitis B | 2 | BeFree,LHGDN |
umls:C0022116 | Ischemia | 2 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
umls:C0023487 | Acute Promyelocytic Leukemia | 2 | BeFree |
umls:C0023890 | Liver Cirrhosis | 2 | BeFree,GAD |
umls:C0026269 | Mitral Valve Stenosis | 2 | BeFree |
umls:C0027022 | Myeloproliferative disease | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0036920 | Sezary Syndrome | 2 | BeFree |
umls:C0037274 | Dermatologic disorders | 2 | BeFree |
umls:C0079731 | B-Cell Lymphomas | 2 | BeFree |
umls:C0079772 | T-Cell Lymphoma | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 2 | BeFree,LHGDN |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C1290884 | Inflammatory disorder | 2 | BeFree |
umls:C1292778 | Chronic myeloproliferative disorder | 2 | BeFree |
umls:C1368683 | Epithelioma | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0006413 | Burkitt Lymphoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0008370 | Cholestasis | 1 | BeFree |
umls:C0008372 | Intrahepatic Cholestasis | 1 | RGD |
umls:C0009319 | Colitis | 1 | BeFree |
umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
umls:C0010346 | Crohn Disease | 1 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0013595 | Eczema | 1 | BeFree |
umls:C0013884 | Filarial Elephantiases | 1 | BeFree |
umls:C0014175 | Endometriosis | 1 | BeFree |
umls:C0017152 | Gastritis | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0018799 | Heart Diseases | 1 | BeFree |
umls:C0019209 | Hepatomegaly | 1 | BeFree |
umls:C0019621 | Histiocytosis, Langerhans-Cell | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0023281 | Leishmaniasis | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
umls:C0023787 | Lipodystrophy | 1 | BeFree,LHGDN |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0024291 | Lymphohistiocytosis, Hemophagocytic | 1 | BeFree |
umls:C0024301 | Lymphoma, Follicular | 1 | BeFree |
umls:C0026848 | Myopathy | 1 | BeFree |
umls:C0026936 | Mycoplasma Infections | 1 | BeFree |
umls:C0027121 | Myositis | 1 | BeFree |
umls:C0028756 | Obesity, Morbid | 1 | GAD |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0032463 | Polycythemia Vera | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0036220 | Kaposi Sarcoma | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | BeFree |
umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
umls:C0149678 | Epstein-Barr Virus Infections | 1 | BeFree |
umls:C0221013 | Mastocytosis, Systemic | 1 | BeFree |
umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
umls:C0262584 | Carcinoma, Small Cell | 1 | BeFree |
umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
umls:C0334287 | Fibrolamellar hepatocellular carcinoma | 1 | BeFree |
umls:C0340970 | Congenital neutropenia | 1 | BeFree |
umls:C0341439 | Chronic liver disease | 1 | BeFree |
umls:C0349639 | Juvenile Myelomonocytic Leukemia | 1 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0549463 | X-Linked Lymphoproliferative Disorder | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0598766 | Leukemogenesis | 1 | BeFree |
umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
umls:C0694533 | Moderate obesity | 1 | BeFree |
umls:C0856536 | Philadelphia chromosome positive | 1 | BeFree |
umls:C0858252 | Breast adenocarcinoma | 1 | BeFree |
umls:C0940937 | precancerous lesions | 1 | BeFree |
umls:C0947751 | Vascular inflammations | 1 | BeFree |
umls:C1142272 | Neutrophilic dermatosis | 1 | BeFree |
umls:C1292753 | Primary Effusion Lymphoma | 1 | BeFree |
umls:C1512326 | Human T-cell lymphotropic virus 1 infection | 1 | BeFree |
umls:C1623038 | Cirrhosis | 1 | BeFree |
umls:C1853118 | Severe congenital neutropenia | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C2004493 | Leukemia, B-Cell | 1 | BeFree |
umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
umls:C3249881 | Infection - suppurative | 1 | BeFree |
umls:C3714619 | Insulin resistance syndrome | 1 | BeFree |