TissGeneSummary for ACRBP |
Gene summary |
Basic gene information | Gene symbol | ACRBP |
Gene name | acrosin binding protein | |
Synonyms | CT23|OY-TES-1|SP32 | |
Cytomap | UCSC genome browser: 12p13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_032489.2, | |
Description | acrosin-binding proteincancer/testis antigen 23cancer/testis antigen OY-TES-1proacrosin binding protein sp32 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608352 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111644 | ||
HPRD : 16322 | ||
Vega : OTTHUMG00000168715 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACRBP | |
BioGPS: 84519 | ||
Pathway | NCI Pathway Interaction Database: ACRBP | |
KEGG: ACRBP | ||
REACTOME: ACRBP | ||
Pathway Commons: ACRBP | ||
Context | iHOP: ACRBP | |
ligand binding site mutation search in PubMed: ACRBP | ||
UCL Cancer Institute: ACRBP | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ACRBP | The mouse sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification. Baker MA, Hetherington L, Reeves GM, Aitken RJ. Proteomics. 2008 Apr;8(8):1720-30. doi: 10.1002/pmic.200701020. (pmid:18340633) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACRBP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.223714221 | -1.021618221 | -1.202096 | 1.91E-06 | 6.91E-06 |
KIRC | 0.417912613 | -0.959631832 | 1.377544444 | 7.21E-18 | 4.66E-17 |
KIRP | 0.640066779 | -0.843164471 | 1.48323125 | 6.21E-06 | 2.69E-05 |
STAD | 0.710969904 | -0.619498846 | 1.33046875 | 0.00134 | 0.006667389 |
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TissGene-miRNA for ACRBP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACRBP |
TissGeneSNV for ACRBP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H321Y | SKCM | 2 |
p.R529* | UCEC | 1 |
p.E202K | BRCA | 1 |
p.R427H | STAD | 1 |
p.D397N | STAD | 1 |
p.Y307* | BRCA | 1 |
p.E297K | HNSC | 1 |
p.A192V | UCEC | 1 |
p.Q293* | OV | 1 |
p.L130F | UCEC | 1 |
p.D453N | SKCM | 1 |
p.S260Y | PAAD | 1 |
p.M298T | COAD | 1 |
p.W308* | SKCM | 1 |
p.P207L | STAD | 1 |
p.Y302X | SKCM | 1 |
p.E283D | UCEC | 1 |
p.S379F | SKCM | 1 |
p.E194V | HNSC | 1 |
p.V176G | SARC | 1 |
p.E463Q | BLCA | 1 |
p.T371I | UCEC | 1 |
p.S102Y | THYM | 1 |
p.R502Q | STAD | 1 |
p.Y302* | SKCM | 1 |
p.Q75* | SKCM | 1 |
p.Q511H | UCEC | 1 |
p.N70D | COAD | 1 |
p.R366Q | HNSC | 1 |
p.G430R | COAD | 1 |
p.G67S | SKCM | 1 |
p.T134I | LUAD | 1 |
p.A140P | CESC | 1 |
p.L374F | READ | 1 |
p.E224Q | SKCM | 1 |
p.R367* | LGG | 1 |
p.P265T | BLCA | 1 |
p.S260Y | STAD | 1 |
p.V526I | LIHC | 1 |
p.L354F | SKCM | 1 |
p.E351K | HNSC | 1 |
p.H438N | THYM | 1 |
p.P403L | SKCM | 1 |
p.W54C | BLCA | 1 |
p.G314S | PAAD | 1 |
p.R290Q | SKCM | 1 |
p.L446I | THYM | 1 |
p.A140D | READ | 1 |
p.S531I | COAD | 1 |
p.G521D | SKCM | 1 |
p.M439I | SKCM | 1 |
p.E283V | STAD | 1 |
p.E228K | SKCM | 1 |
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TissGeneCNV for ACRBP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACRBP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ345731 | ACRBP-MLXIP | chr12:6749321 | chr12:122627413 |
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TissGeneNet for ACRBP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACRBP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACRBP |
TissGeneDrug for ACRBP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACRBP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153594 | Malignant neoplasm of testis | 3 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C3495559 | Juvenile arthritis | 1 | CTD_human |