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| TissGeneSummary for MCHR2 |
 Gene summary |
| Basic gene information | Gene symbol | MCHR2 |
| Gene name | melanin-concentrating hormone receptor 2 | |
| Synonyms | GPR145|GPRv17|MCH-2R|MCH-R2|MCH2|MCH2R|MCHR-2|SLT | |
| Cytomap | UCSC genome browser: 6q16 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001040179.1, NM_032503.2, | |
| Description | G protein-coupled receptor 145G protein-coupled receptor sltG-protein coupled receptor 145MCH receptor 2melanin-concentrating hormone 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606111 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000152034 | ||
| HPRD : 12088 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MCHR2 | |
| BioGPS: 84539 | ||
| Pathway | NCI Pathway Interaction Database: MCHR2 | |
| KEGG: MCHR2 | ||
| REACTOME: MCHR2 | ||
| Pathway Commons: MCHR2 | ||
| Context | iHOP: MCHR2 | |
| ligand binding site mutation search in PubMed: MCHR2 | ||
| UCL Cancer Institute: MCHR2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of MCHR2 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MCHR2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -0.479337547 | 0.534204761 | -1.013542308 | 2.29E-06 | 1.18E-05 |
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| TissGene-miRNA for MCHR2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MCHR2 |
| TissGeneSNV for MCHR2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E328K | SKCM | 2 |
| p.G333E | SKCM | 2 |
| p.E14K | READ | 2 |
| p.P209S | SKCM | 2 |
| p.G97E | SKCM | 2 |
| p.D193N | SKCM | 2 |
| p.S19F | SKCM | 2 |
| p.L89F | SKCM | 1 |
| p.A78S | STAD | 1 |
| p.V35I | ESCA | 1 |
| p.L89P | SKCM | 1 |
| p.H91Y | LUAD | 1 |
| p.R95Q | ESCA | 1 |
| p.P239S | SKCM | 1 |
| p.R323I | LUSC | 1 |
| p.Y26N | LUAD | 1 |
| p.W99L | LUAD | 1 |
| p.S30R | BLCA | 1 |
| p.S240I | LUAD | 1 |
| p.V170I | SKCM | 1 |
| p.E14K | CESC | 1 |
| p.R152W | PRAD | 1 |
| p.P167L | CESC | 1 |
| p.S172L | COAD | 1 |
| p.R145S | SKCM | 1 |
| p.S291F | SKCM | 1 |
| p.E23* | UCS | 1 |
| p.M252T | LUAD | 1 |
| p.V136I | CESC | 1 |
| p.V174F | LUAD | 1 |
| p.R152W | STAD | 1 |
| p.E226D | HNSC | 1 |
| p.K251N | BLCA | 1 |
| p.G311E | SKCM | 1 |
| p.G42R | SKCM | 1 |
| p.E98Q | BLCA | 1 |
| p.G85E | SKCM | 1 |
| p.R95* | SKCM | 1 |
| p.A324S | HNSC | 1 |
| p.G96E | SKCM | 1 |
| p.C216R | LGG | 1 |
| p.P303H | LUAD | 1 |
| p.Q92K | KIRC | 1 |
| p.S39F | UCEC | 1 |
| p.H5Y | COAD | 1 |
| p.Y171H | UCEC | 1 |
| p.M247I | STAD | 1 |
| p.S7C | BRCA | 1 |
| p.H91Y | SKCM | 1 |
| p.G51V | LUAD | 1 |
| p.M332I | SKCM | 1 |
| p.K232R | SKCM | 1 |
| p.V273L | LUSC | 1 |
| p.Q314R | OV | 1 |
| p.A119T | PAAD | 1 |
| p.R152W | LAML | 1 |
| p.N154H | LUAD | 1 |
| p.W158L | LUAD | 1 |
| p.E98G | COAD | 1 |
| p.W20* | LUSC | 1 |
| p.R152Q | ESCA | 1 |
| p.R140X | SKCM | 1 |
| p.D113N | SKCM | 1 |
| p.Y288C | BRCA | 1 |
| p.S111F | SKCM | 1 |
| p.R140* | SKCM | 1 |
| p.I41V | LUAD | 1 |
| p.I60M | LUSC | 1 |
| p.R131K | LUAD | 1 |
| p.R95P | HNSC | 1 |
| p.R143H | LUSC | 1 |
| p.P280L | COAD | 1 |
| p.G103E | SKCM | 1 |
| p.G102W | GBM | 1 |
| p.V136I | COAD | 1 |
| p.K327N | LUAD | 1 |
| p.W196X | SKCM | 1 |
| p.E23X | UCS | 1 |
| p.G48V | LUAD | 1 |
| p.F208L | HNSC | 1 |
| p.D187N | UCEC | 1 |
| p.R95* | LUAD | 1 |
| p.D130E | ESCA | 1 |
| p.I220T | GBM | 1 |
| p.Q279E | PCPG | 1 |
| p.V181F | KIRC | 1 |
| p.A25D | STAD | 1 |
| p.F340I | COAD | 1 |
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| TissGeneCNV for MCHR2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MCHR2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LGG | TCGA-DU-7006-01A | RPS6KA2-MCHR2 | 5'UTR-5'UTR | chr6:167271687 | chr6:100404050 |
| TCGAfusionPortal | PRADA | LGG | TCGA-DU-7006-01A | RPS6KA2-MCHR2 | CDS-5UTR | Chr6:167271688 | Chr6:100404050 |
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| TissGeneNet for MCHR2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| COAD (tumor) | COAD (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| KICH (tumor) | KICH (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| STAD (tumor) | STAD (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| THCA (tumor) | THCA (normal) |
| MCHR2, PMCH (tumor) | MCHR2, PMCH (normal) |
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| TissGeneProg for MCHR2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MCHR2 |
| TissGeneDrug for MCHR2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MCHR2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019061 | Hemolytic-Uremic Syndrome | 3 | BeFree |
| umls:C0028754 | Obesity | 3 | BeFree,GAD |
| umls:C0005586 | Bipolar Disorder | 2 | BeFree,GAD |
| umls:C0011992 | Infantile Diarrhea | 2 | BeFree |
| umls:C0014836 | Escherichia coli Infections | 2 | BeFree |
| umls:C0151594 | Hemorrhagic diarrhea | 2 | BeFree |
| umls:C0302810 | Uremia syndrome | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0004936 | Mental disorders | 1 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0011633 | Dermatomyositis | 1 | BeFree |
| umls:C0018206 | granulosa cell tumor | 1 | BeFree |
| umls:C0020175 | Hunger | 1 | BeFree |
| umls:C0028756 | Obesity, Morbid | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0151565 | Hemorrhagic colitis | 1 | BeFree |
| umls:C0221056 | Adult type dermatomyositis | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0263666 | Dermatomyositis, Childhood Type | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0871189 | Psychotic symptom | 1 | BeFree |
| umls:C1658953 | tumor vasculature | 1 | BeFree |
| umls:C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | BeFree |
| umls:C1852197 | MAJOR AFFECTIVE DISORDER 1 | 1 | BeFree |
| umls:C1970943 | MAJOR AFFECTIVE DISORDER 4 | 1 | BeFree |
| umls:C1970944 | MAJOR AFFECTIVE DISORDER 5 | 1 | BeFree |
| umls:C1970945 | MAJOR AFFECTIVE DISORDER 6 | 1 | BeFree |
| umls:C2362324 | Pediatric Obesity | 1 | BeFree |
| umls:C2700438 | MAJOR AFFECTIVE DISORDER 7 | 1 | BeFree |
| umls:C2700439 | MAJOR AFFECTIVE DISORDER 8 | 1 | BeFree |
| umls:C2700440 | MAJOR AFFECTIVE DISORDER 9 | 1 | BeFree |
| umls:C2931785 | Juvenile dermatomyositis | 1 | BeFree |
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