TissGeneSummary for ST6GAL2 |
Gene summary |
Basic gene information | Gene symbol | ST6GAL2 |
Gene name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | |
Synonyms | SIAT2|ST6GalII | |
Cytomap | UCSC genome browser: 2q11.2-q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001142351.1, NM_001142352.1,NM_032528.2, | |
Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2alpha 2,6-ST 2beta-galactoside alpha-2,6-sialyltransferase 2beta-galactoside alpha-2,6-sialyltransferase IIsialyltransferase 2 (monosialoganglioside sialyltransferase) | |
Modification date | 20141207 | |
dbXrefs | MIM : 608472 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144057 | ||
HPRD : 12237 | ||
Vega : OTTHUMG00000130923 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ST6GAL2 | |
BioGPS: 84620 | ||
Pathway | NCI Pathway Interaction Database: ST6GAL2 | |
KEGG: ST6GAL2 | ||
REACTOME: ST6GAL2 | ||
Pathway Commons: ST6GAL2 | ||
Context | iHOP: ST6GAL2 | |
ligand binding site mutation search in PubMed: ST6GAL2 | ||
UCL Cancer Institute: ST6GAL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTTHCA | |
Reference showing the relevant tissue of ST6GAL2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0009311 | oligosaccharide metabolic process | 12235148 | GO:0097503 | sialylation | 12235148 | GO:0009311 | oligosaccharide metabolic process | 12235148 | GO:0097503 | sialylation | 12235148 |
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TissGeneExp for ST6GAL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.722185931 | -1.072169931 | -2.650016 | 1.15E-08 | 6.06E-08 |
LIHC | -2.548949931 | 1.021596069 | -3.570546 | 1.54E-15 | 4.96E-14 |
BRCA | 1.774800561 | 0.384821613 | 1.389978947 | 1.25E-09 | 4.42E-09 |
PRAD | -0.994122854 | 0.158529069 | -1.152651923 | 3.36E-08 | 3.62E-07 |
HNSC | -1.181076163 | 0.249726162 | -1.430802326 | 0.00158 | 0.005064103 |
STAD | -2.094095931 | -0.078495931 | -2.0156 | 0.000464 | 0.002859003 |
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TissGene-miRNA for ST6GAL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-4465 | MIMAT0018992 | 0.021 | -0.26 | 78 |
ACC | hsa-miR-4465 | MIMAT0018992 | 0.021 | -0.26 | 78 |
ACC | hsa-miR-381-3p | MIMAT0000736 | 0.013 | -0.28 | 78 |
ACC | hsa-miR-381-3p | MIMAT0000736 | 0.013 | -0.28 | 78 |
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TissGeneMut for ST6GAL2 |
TissGeneSNV for ST6GAL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E313K | SKCM | 4 |
p.H90Y | SKCM | 4 |
p.S346L | SKCM | 3 |
p.R11Q | SKCM | 3 |
p.P164S | SKCM | 2 |
p.E455K | SKCM | 2 |
p.S309F | SKCM | 2 |
p.R220H | STAD | 2 |
p.P151S | SKCM | 2 |
p.S113L | SKCM | 2 |
p.S88F | SKCM | 2 |
p.D128N | SKCM | 2 |
p.L80M | STAD | 1 |
p.S459Y | LUAD | 1 |
p.G501R | LUAD | 1 |
p.E455K | LUSC | 1 |
p.H66N | LUAD | 1 |
p.R505C | SKCM | 1 |
p.Q404* | SKCM | 1 |
p.G501W | UCEC | 1 |
p.G87S | KIRC | 1 |
p.G266S | STAD | 1 |
p.R77H | GBM | 1 |
p.A516V | STAD | 1 |
p.Q287* | SKCM | 1 |
p.I343L | SKCM | 1 |
p.S142R | LUAD | 1 |
p.I395S | BLCA | 1 |
p.N211K | LUAD | 1 |
p.M12V | SKCM | 1 |
p.P53L | LUAD | 1 |
p.P484T | LUAD | 1 |
p.G149E | SKCM | 1 |
p.D75H | LUAD | 1 |
p.A373V | UCEC | 1 |
p.G480E | SKCM | 1 |
p.G235R | SKCM | 1 |
p.F150C | SKCM | 1 |
p.H452Q | LUAD | 1 |
p.E110K | SKCM | 1 |
p.V54L | LUAD | 1 |
p.P70T | LUAD | 1 |
p.P405L | SKCM | 1 |
p.R505C | HNSC | 1 |
p.E187* | ACC | 1 |
p.Q167X | STAD | 1 |
p.R77H | PCPG | 1 |
p.R82C | LUAD | 1 |
p.F45S | LUAD | 1 |
p.G72V | LUAD | 1 |
p.R260H | PAAD | 1 |
p.G336E | SKCM | 1 |
p.R194K | SKCM | 1 |
p.K119X | SKCM | 1 |
p.V39I | LUAD | 1 |
p.K6N | LUAD | 1 |
p.I314L | LIHC | 1 |
p.R398H | LGG | 1 |
p.P219S | SKCM | 1 |
p.V116M | GBM | 1 |
p.D191N | COAD | 1 |
p.P520T | LUAD | 1 |
p.P70L | STAD | 1 |
p.Q422* | SKCM | 1 |
p.G15E | KIRC | 1 |
p.G56R | PRAD | 1 |
p.G235W | LUSC | 1 |
p.S200F | LUAD | 1 |
p.R237L | LUAD | 1 |
p.D318G | ESCA | 1 |
p.R258H | GBM | 1 |
p.S44F | SKCM | 1 |
p.R194M | STAD | 1 |
p.E332K | SKCM | 1 |
p.P386Q | LUAD | 1 |
p.S529Y | LUAD | 1 |
p.N34S | SKCM | 1 |
p.A326S | LUAD | 1 |
p.D191N | UCEC | 1 |
p.S360L | OV | 1 |
p.Q430K | BLCA | 1 |
p.R342C | GBM | 1 |
p.K119N | HNSC | 1 |
p.A282V | SKCM | 1 |
p.P53S | BRCA | 1 |
p.S346L | LGG | 1 |
p.R172W | THYM | 1 |
p.A475T | UCEC | 1 |
p.D334Y | UCEC | 1 |
p.V492L | LUAD | 1 |
p.G240E | SKCM | 1 |
p.Q493H | ACC | 1 |
p.V168L | KIRP | 1 |
p.T499K | LUAD | 1 |
p.R237H | BLCA | 1 |
p.F30V | STAD | 1 |
p.E464* | ACC | 1 |
p.Q167* | STAD | 1 |
p.W99X | SKCM | 1 |
p.T263M | STAD | 1 |
p.G15E | CESC | 1 |
p.R342C | PAAD | 1 |
p.G117R | LUAD | 1 |
p.D358E | ESCA | 1 |
p.V212I | LUAD | 1 |
p.E464X | ACC | 1 |
p.R461Q | STAD | 1 |
p.R172W | HNSC | 1 |
p.E160K | SKCM | 1 |
p.L409P | OV | 1 |
p.R505C | STAD | 1 |
p.G154E | SKCM | 1 |
p.D474N | SKCM | 1 |
p.T499M | COAD | 1 |
p.H289N | LIHC | 1 |
p.K119* | SKCM | 1 |
p.G154V | LUAD | 1 |
p.D227N | SKCM | 1 |
p.E423D | LUAD | 1 |
p.R494H | COAD | 1 |
p.P411S | READ | 1 |
p.Q422H | COAD | 1 |
p.G15R | UCEC | 1 |
p.A36T | THYM | 1 |
p.R277W | UVM | 1 |
p.H410Y | SKCM | 1 |
p.G73D | SKCM | 1 |
p.A76S | STAD | 1 |
p.F27L | ESCA | 1 |
p.L495M | LUAD | 1 |
p.E470K | ESCA | 1 |
p.S88F | SARC | 1 |
p.E37D | STAD | 1 |
p.R220H | PRAD | 1 |
p.R239H | UCEC | 1 |
p.N337S | READ | 1 |
p.A302S | LUAD | 1 |
p.P520T | ESCA | 1 |
p.E313V | SKCM | 1 |
p.A91V | READ | 1 |
p.P153L | SKCM | 1 |
p.S456A | ESCA | 1 |
p.F163L | HNSC | 1 |
p.S346L | STAD | 1 |
p.S214F | SKCM | 1 |
p.R449K | SKCM | 1 |
p.E110Q | CESC | 1 |
p.R291S | LUAD | 1 |
p.E470K | SKCM | 1 |
p.Q101* | UCEC | 1 |
p.H528R | STAD | 1 |
p.G157S | HNSC | 1 |
p.P81A | BLCA | 1 |
p.R11Q | UCEC | 1 |
p.W99* | SKCM | 1 |
p.A79S | LUAD | 1 |
p.H90Y | LUSC | 1 |
p.R82H | HNSC | 1 |
p.G235V | LUAD | 1 |
p.G15E | SKCM | 1 |
p.V509M | SKCM | 1 |
p.R77C | LUAD | 1 |
p.D502N | SKCM | 1 |
p.E268K | SKCM | 1 |
p.N324T | SKCM | 1 |
p.V236M | SKCM | 1 |
p.R206W | LUAD | 1 |
p.I421V | STAD | 1 |
p.G87S | COAD | 1 |
p.P512H | LUAD | 1 |
p.S435C | LUAD | 1 |
p.L52Q | LUAD | 1 |
p.R178L | COAD | 1 |
p.M62I | GBM | 1 |
p.P352L | SKCM | 1 |
p.D128N | CESC | 1 |
p.P53L | STAD | 1 |
p.K412T | STAD | 1 |
p.P219L | SKCM | 1 |
p.S435P | STAD | 1 |
p.D130Y | COAD | 1 |
p.G161E | SKCM | 1 |
p.P53S | GBM | 1 |
p.Y468C | LUSC | 1 |
p.I28M | HNSC | 1 |
p.Y407C | SKCM | 1 |
p.E488K | SKCM | 1 |
p.A516V | COAD | 1 |
p.A79V | STAD | 1 |
p.G154R | COAD | 1 |
p.G330D | COAD | 1 |
p.G480R | COAD | 1 |
p.G117R | SKCM | 1 |
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TissGeneCNV for ST6GAL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ST6GAL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW896087 | LARGE-ST6GAL2 | chr22:34302785 | chr2:107429182 |
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TissGeneNet for ST6GAL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ST6GAL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ST6GAL2 |
TissGeneDrug for ST6GAL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ST6GAL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |