TissGeneSummary for KIF2B |
Gene summary |
Basic gene information | Gene symbol | KIF2B |
Gene name | kinesin family member 2B | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q22 | |
Type of gene | protein-coding | |
RefGenes | NM_032559.4, | |
Description | kinesin proteinkinesin-like protein KIF2B | |
Modification date | 20141207 | |
dbXrefs | MIM : 615142 | |
HGNC : HGNC | ||
Ensembl : ENSG00000141200 | ||
HPRD : 10053 | ||
Vega : OTTHUMG00000177756 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIF2B | |
BioGPS: 84643 | ||
Pathway | NCI Pathway Interaction Database: KIF2B | |
KEGG: KIF2B | ||
REACTOME: KIF2B | ||
Pathway Commons: KIF2B | ||
Context | iHOP: KIF2B | |
ligand binding site mutation search in PubMed: KIF2B | ||
UCL Cancer Institute: KIF2B | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | TiGER,GTExHPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIF2B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KIF2B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for KIF2B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KIF2B |
TissGeneSNV for KIF2B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E186K | SKCM | 3 |
p.E169K | SKCM | 3 |
p.A639T | STAD | 2 |
p.V668L | LUAD | 2 |
p.R195C | SKCM | 2 |
p.D271N | UCEC | 2 |
p.M118I | SKCM | 2 |
p.K593N | STAD | 2 |
p.R437Q | SKCM | 2 |
p.E452K | SKCM | 2 |
p.D579N | SKCM | 2 |
p.R163H | LGG | 2 |
p.R504W | STAD | 2 |
p.D267N | SKCM | 1 |
p.T113M | BRCA | 1 |
p.V216I | STAD | 1 |
p.R171Q | STAD | 1 |
p.H551N | HNSC | 1 |
p.K671* | LUAD | 1 |
p.I508V | LUSC | 1 |
p.M296I | SKCM | 1 |
p.R226* | BLCA | 1 |
p.S461T | LUAD | 1 |
p.P120T | LUAD | 1 |
p.W151* | SKCM | 1 |
p.A33V | GBM | 1 |
p.G454R | SKCM | 1 |
p.R171X | STAD | 1 |
p.Q430H | OV | 1 |
p.S137R | ESCA | 1 |
p.D635N | SKCM | 1 |
p.P209T | LUAD | 1 |
p.V244A | BRCA | 1 |
p.N261K | LUAD | 1 |
p.T57M | READ | 1 |
p.Q210E | LUSC | 1 |
p.M188I | LUAD | 1 |
p.V598F | LUAD | 1 |
p.D505E | LUAD | 1 |
p.E59* | BLCA | 1 |
p.T113M | HNSC | 1 |
p.L150P | STAD | 1 |
p.A639T | ESCA | 1 |
p.R213H | STAD | 1 |
p.E621K | SKCM | 1 |
p.R578K | SKCM | 1 |
p.E654K | SKCM | 1 |
p.N50K | LUAD | 1 |
p.V279L | LUAD | 1 |
p.P89R | LUAD | 1 |
p.D633N | SKCM | 1 |
p.R174H | UCEC | 1 |
p.Q35* | ESCA | 1 |
p.E74D | UCEC | 1 |
p.R171Q | BLCA | 1 |
p.V133M | LUAD | 1 |
p.E405D | UCEC | 1 |
p.E152K | SKCM | 1 |
p.K220T | STAD | 1 |
p.T500P | PCPG | 1 |
p.V668A | TGCT | 1 |
p.M439I | UCEC | 1 |
p.G613W | LUAD | 1 |
p.T47M | LAML | 1 |
p.E405K | COAD | 1 |
p.E62* | SKCM | 1 |
p.L83M | LUAD | 1 |
p.L377F | SKCM | 1 |
p.L338F | LUAD | 1 |
p.G407W | STAD | 1 |
p.A284T | DLBC | 1 |
p.R36H | READ | 1 |
p.R171* | STAD | 1 |
p.L98F | PRAD | 1 |
p.R226* | GBM | 1 |
p.E405K | SKCM | 1 |
p.R195C | ESCA | 1 |
p.V246A | PAAD | 1 |
p.A484T | SKCM | 1 |
p.R110H | LUAD | 1 |
p.T310M | LAML | 1 |
p.S104L | CESC | 1 |
p.G570R | SKCM | 1 |
p.A477T | HNSC | 1 |
p.R226Q | LUAD | 1 |
p.N276D | COAD | 1 |
p.A101V | SKCM | 1 |
p.P239L | SKCM | 1 |
p.V376L | LUAD | 1 |
p.A484P | HNSC | 1 |
p.V218M | BLCA | 1 |
p.E62G | GBM | 1 |
p.P81A | SKCM | 1 |
p.Q618K | LGG | 1 |
p.R40W | THYM | 1 |
p.S249F | HNSC | 1 |
p.G613E | SKCM | 1 |
p.A561E | LUAD | 1 |
p.Q210H | HNSC | 1 |
p.D199H | BRCA | 1 |
p.A477V | LUAD | 1 |
p.R552S | LUAD | 1 |
p.R535S | SARC | 1 |
p.R462Q | STAD | 1 |
p.Q35X | ESCA | 1 |
p.C299F | STAD | 1 |
p.R213H | UCEC | 1 |
p.Q618R | UCEC | 1 |
p.R462W | GBM | 1 |
p.D650Y | BLCA | 1 |
p.L666F | STAD | 1 |
p.R174H | STAD | 1 |
p.R40Q | STAD | 1 |
p.K434N | LUAD | 1 |
p.D349E | LUAD | 1 |
p.M439R | UCS | 1 |
p.R163H | STAD | 1 |
p.S512T | STAD | 1 |
p.R36C | LGG | 1 |
p.E74D | READ | 1 |
p.A651S | LUAD | 1 |
p.C396X | ESCA | 1 |
p.E28* | LUAD | 1 |
p.P239S | SKCM | 1 |
p.S96F | SKCM | 1 |
p.I406M | STAD | 1 |
p.R563K | SKCM | 1 |
p.W60L | LUAD | 1 |
p.E211K | SKCM | 1 |
p.K473R | LUAD | 1 |
p.Q383* | BLCA | 1 |
p.A469E | LUSC | 1 |
p.A33V | PRAD | 1 |
p.P94H | LUSC | 1 |
p.D254E | LGG | 1 |
p.R160Q | SKCM | 1 |
p.S617G | LUSC | 1 |
p.H197Y | PRAD | 1 |
p.R174C | UCEC | 1 |
p.N276S | LUAD | 1 |
p.R257C | SKCM | 1 |
p.A175S | LUAD | 1 |
p.P148L | HNSC | 1 |
p.G558R | SKCM | 1 |
p.R221W | PRAD | 1 |
p.K114N | KIRC | 1 |
p.A627D | LUSC | 1 |
p.S104L | DLBC | 1 |
p.Y194D | PAAD | 1 |
p.K657E | SKCM | 1 |
p.M245L | ESCA | 1 |
p.T514I | LUAD | 1 |
p.S512A | LUAD | 1 |
p.R107M | PAAD | 1 |
p.S444P | SARC | 1 |
p.M142I | SKCM | 1 |
p.L255F | SKCM | 1 |
p.T283I | SKCM | 1 |
p.R221W | UCEC | 1 |
p.P585A | BRCA | 1 |
p.Q285L | LUSC | 1 |
p.A101T | SKCM | 1 |
p.V216I | COAD | 1 |
p.D129N | SKCM | 1 |
p.P91A | LUAD | 1 |
p.P490H | HNSC | 1 |
p.A496T | LUAD | 1 |
p.V65F | LUAD | 1 |
p.T113M | UCEC | 1 |
p.N242I | LIHC | 1 |
p.V394M | LUAD | 1 |
p.G306E | SKCM | 1 |
p.L131M | LUAD | 1 |
p.S512A | STAD | 1 |
p.A449S | LIHC | 1 |
p.E289K | SKCM | 1 |
p.S641F | LUAD | 1 |
p.V598A | KIRP | 1 |
p.R174H | LUSC | 1 |
p.H667Y | SKCM | 1 |
p.L503I | STAD | 1 |
p.E186K | STAD | 1 |
p.F356I | GBM | 1 |
p.E186K | UCEC | 1 |
p.E277K | SKCM | 1 |
p.Q304X | LIHC | 1 |
p.Q159K | LUSC | 1 |
p.R171Q | SKCM | 1 |
p.R213C | UCEC | 1 |
p.A333T | LIHC | 1 |
p.K373M | PAAD | 1 |
p.A86D | LUAD | 1 |
p.E192K | UCEC | 1 |
p.V133L | LUAD | 1 |
p.N276K | LUAD | 1 |
p.V376A | UCEC | 1 |
p.G570V | THYM | 1 |
p.E480K | SKCM | 1 |
p.G558R | STAD | 1 |
p.R174C | LUAD | 1 |
p.D447Y | READ | 1 |
p.V587A | LGG | 1 |
p.N419T | STAD | 1 |
p.R110H | GBM | 1 |
p.P8S | SKCM | 1 |
p.H554N | LUAD | 1 |
p.H559L | BLCA | 1 |
p.T180N | LUAD | 1 |
p.D349H | BLCA | 1 |
p.D608N | SKCM | 1 |
p.K146M | STAD | 1 |
p.N538I | LUSC | 1 |
p.R640L | LUAD | 1 |
p.W115S | STAD | 1 |
p.A627G | LUSC | 1 |
p.E161K | SKCM | 1 |
p.F282Y | LUAD | 1 |
p.K658I | HNSC | 1 |
p.G308V | LUSC | 1 |
p.A33V | COAD | 1 |
p.D108N | SKCM | 1 |
p.P602S | CHOL | 1 |
p.G361E | READ | 1 |
p.H632N | LUAD | 1 |
p.E467* | LUAD | 1 |
p.T320M | COAD | 1 |
p.E452Q | LUAD | 1 |
p.Q385H | LUSC | 1 |
p.P522S | SKCM | 1 |
p.D579E | COAD | 1 |
p.V116G | LGG | 1 |
p.D505G | ESCA | 1 |
p.C140S | LUAD | 1 |
p.R462Q | SKCM | 1 |
p.G606W | ESCA | 1 |
p.E161G | SKCM | 1 |
p.I153M | STAD | 1 |
p.L150I | LUAD | 1 |
p.R504Q | SKCM | 1 |
p.F264L | LUSC | 1 |
p.L601S | UCEC | 1 |
p.V428M | UCEC | 1 |
p.D349N | SKCM | 1 |
p.P493L | LUSC | 1 |
p.R504W | TGCT | 1 |
p.S572L | SKCM | 1 |
p.R134S | LGG | 1 |
p.R160W | HNSC | 1 |
p.E467Q | LGG | 1 |
p.R504W | UCEC | 1 |
p.G306R | SKCM | 1 |
p.S617I | THYM | 1 |
p.P120R | ACC | 1 |
p.T113M | READ | 1 |
p.D254Y | LUAD | 1 |
p.D608G | LUAD | 1 |
p.R257H | BRCA | 1 |
p.A333V | PAAD | 1 |
p.K669R | STAD | 1 |
p.S423Y | LUAD | 1 |
p.A112T | GBM | 1 |
p.G314V | LUAD | 1 |
p.R504Q | STAD | 1 |
p.A112T | LUAD | 1 |
p.N488H | STAD | 1 |
p.A639S | LUAD | 1 |
p.P602S | LUSC | 1 |
p.G303W | LUAD | 1 |
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TissGeneCNV for KIF2B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KIF2B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KIF2B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KIF2B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KIF2B |
TissGeneDrug for KIF2B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KIF2B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0028754 | Obesity | 1 | GAD |