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TissGeneSummary for PLA2G12B |
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Basic gene information | Gene symbol | PLA2G12B |
Gene name | phospholipase A2, group XIIB | |
Synonyms | GXIIB|GXIIIsPLA2|PLA2G13 | |
Cytomap | UCSC genome browser: 10q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_032562.3, | |
Description | group XIIB secretory phospholipase A2-like proteingroup XIII secreted phospholipase A2group XIII secretory phospholipase A2-like proteinphospholipase A2, group XIIIsPLA2-GXIIB | |
Modification date | 20141207 | |
dbXrefs | MIM : 611653 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138308 | ||
HPRD : 10155 | ||
Vega : OTTHUMG00000018446 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PLA2G12B | |
BioGPS: 84647 | ||
Pathway | NCI Pathway Interaction Database: PLA2G12B | |
KEGG: PLA2G12B | ||
REACTOME: PLA2G12B | ||
Pathway Commons: PLA2G12B | ||
Context | iHOP: PLA2G12B | |
ligand binding site mutation search in PubMed: PLA2G12B | ||
UCL Cancer Institute: PLA2G12B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of PLA2G12B | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for PLA2G12B |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.006972126 | 0.961539874 | -2.968512 | 3.31E-05 | 9.50E-05 |
LUAD | 0.272118218 | 1.950513046 | -1.678394828 | 2.80E-05 | 7.68E-05 |
LUSC | -2.228805852 | 1.558292187 | -3.787098039 | 8.75E-28 | 2.78E-26 |
THCA | 1.11837567 | -2.469993821 | 3.588369492 | 1.09E-17 | 2.41E-16 |
KIRC | 2.924457874 | 1.731748151 | 1.192709722 | 0.0124 | 0.020402643 |
KIRP | -0.638367126 | 2.483754749 | -3.122121875 | 4.03E-05 | 0.000150337 |
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TissGene-miRNA for PLA2G12B |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PLA2G12B |
TissGeneSNV for PLA2G12B |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E193K | LUAD | 1 |
p.Q181* | SKCM | 1 |
p.V46I | SARC | 1 |
p.L103F | BLCA | 1 |
p.T27M | STAD | 1 |
p.V169M | COAD | 1 |
p.D51N | SKCM | 1 |
p.L10M | SKCM | 1 |
p.E189Q | CESC | 1 |
p.Q20* | UCEC | 1 |
p.C118W | LUAD | 1 |
p.R69X | PRAD | 1 |
p.Q181X | SKCM | 1 |
p.R37W | SKCM | 1 |
p.G89C | LIHC | 1 |
p.S139W | HNSC | 1 |
p.S160F | SKCM | 1 |
p.R37G | LUAD | 1 |
p.R146W | UCEC | 1 |
p.S13G | STAD | 1 |
p.P106Q | ESCA | 1 |
p.R134Q | STAD | 1 |
p.M178I | CESC | 1 |
p.R69* | PRAD | 1 |
p.S52F | SKCM | 1 |
p.S32* | CESC | 1 |
p.R40Q | UCEC | 1 |
p.R134Q | LGG | 1 |
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TissGeneCNV for PLA2G12B |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PLA2G12B |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-MN-A4N5-01A | AMMECR1-PLA2G12B | Out-of-frame | ChrX:109507717 | Chr10:74702498 |
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TissGeneNet for PLA2G12B |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PLA2G12B |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PLA2G12B |
TissGeneDrug for PLA2G12B |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PLA2G12B |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 1 | GAD |