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| TissGeneSummary for PLA2G12B |
 Gene summary |
| Basic gene information | Gene symbol | PLA2G12B |
| Gene name | phospholipase A2, group XIIB | |
| Synonyms | GXIIB|GXIIIsPLA2|PLA2G13 | |
| Cytomap | UCSC genome browser: 10q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032562.3, | |
| Description | group XIIB secretory phospholipase A2-like proteingroup XIII secreted phospholipase A2group XIII secretory phospholipase A2-like proteinphospholipase A2, group XIIIsPLA2-GXIIB | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611653 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138308 | ||
| HPRD : 10155 | ||
| Vega : OTTHUMG00000018446 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLA2G12B | |
| BioGPS: 84647 | ||
| Pathway | NCI Pathway Interaction Database: PLA2G12B | |
| KEGG: PLA2G12B | ||
| REACTOME: PLA2G12B | ||
| Pathway Commons: PLA2G12B | ||
| Context | iHOP: PLA2G12B | |
| ligand binding site mutation search in PubMed: PLA2G12B | ||
| UCL Cancer Institute: PLA2G12B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of PLA2G12B | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PLA2G12B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.006972126 | 0.961539874 | -2.968512 | 3.31E-05 | 9.50E-05 |
| LUAD | 0.272118218 | 1.950513046 | -1.678394828 | 2.80E-05 | 7.68E-05 |
| LUSC | -2.228805852 | 1.558292187 | -3.787098039 | 8.75E-28 | 2.78E-26 |
| THCA | 1.11837567 | -2.469993821 | 3.588369492 | 1.09E-17 | 2.41E-16 |
| KIRC | 2.924457874 | 1.731748151 | 1.192709722 | 0.0124 | 0.020402643 |
| KIRP | -0.638367126 | 2.483754749 | -3.122121875 | 4.03E-05 | 0.000150337 |
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| TissGene-miRNA for PLA2G12B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PLA2G12B |
| TissGeneSNV for PLA2G12B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E193K | LUAD | 1 |
| p.Q181* | SKCM | 1 |
| p.V46I | SARC | 1 |
| p.L103F | BLCA | 1 |
| p.T27M | STAD | 1 |
| p.V169M | COAD | 1 |
| p.D51N | SKCM | 1 |
| p.L10M | SKCM | 1 |
| p.E189Q | CESC | 1 |
| p.Q20* | UCEC | 1 |
| p.C118W | LUAD | 1 |
| p.R69X | PRAD | 1 |
| p.Q181X | SKCM | 1 |
| p.R37W | SKCM | 1 |
| p.G89C | LIHC | 1 |
| p.S139W | HNSC | 1 |
| p.S160F | SKCM | 1 |
| p.R37G | LUAD | 1 |
| p.R146W | UCEC | 1 |
| p.S13G | STAD | 1 |
| p.P106Q | ESCA | 1 |
| p.R134Q | STAD | 1 |
| p.M178I | CESC | 1 |
| p.R69* | PRAD | 1 |
| p.S52F | SKCM | 1 |
| p.S32* | CESC | 1 |
| p.R40Q | UCEC | 1 |
| p.R134Q | LGG | 1 |
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| TissGeneCNV for PLA2G12B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PLA2G12B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LUAD | TCGA-MN-A4N5-01A | AMMECR1-PLA2G12B | Out-of-frame | ChrX:109507717 | Chr10:74702498 |
| Top |
| TissGeneNet for PLA2G12B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| PLA2G12B, HNF4A (tumor) | PLA2G12B, HNF4A (normal) |
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| Top |
| TissGeneProg for PLA2G12B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PLA2G12B |
| TissGeneDrug for PLA2G12B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PLA2G12B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 1 | GAD |
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