TissGeneSummary for CCDC62 |
Gene summary |
Basic gene information | Gene symbol | CCDC62 |
Gene name | coiled-coil domain containing 62 | |
Synonyms | CT109|ERAP75|TSP-NY | |
Cytomap | UCSC genome browser: 12q24.31 | |
Type of gene | protein-coding | |
RefGenes | NM_032573.5, NM_201435.4,NR_027918.2, | |
Description | aaa-proteincancer/testis antigen 109coiled-coil domain-containing protein 60coiled-coil domain-containing protein 62testis-specific protein TSP-NY | |
Modification date | 20141207 | |
dbXrefs | MIM : 613481 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130783 | ||
HPRD : 15575 | ||
Vega : OTTHUMG00000168764 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC62 | |
BioGPS: 84660 | ||
Pathway | NCI Pathway Interaction Database: CCDC62 | |
KEGG: CCDC62 | ||
REACTOME: CCDC62 | ||
Pathway Commons: CCDC62 | ||
Context | iHOP: CCDC62 | |
ligand binding site mutation search in PubMed: CCDC62 | ||
UCL Cancer Institute: CCDC62 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC62 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 19126643 | GO:0071392 | cellular response to estradiol stimulus | 19126643 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 19126643 | GO:0071392 | cellular response to estradiol stimulus | 19126643 |
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TissGeneExp for CCDC62 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC62 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC62 |
TissGeneSNV for CCDC62 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R82I | COAD | 2 |
p.R327T | BRCA | 1 |
p.R155* | BLCA | 1 |
p.S579F | BRCA | 1 |
p.K120Q | CESC | 1 |
p.E491* | ESCA | 1 |
p.R40* | UCEC | 1 |
p.K166N | LUAD | 1 |
p.V532M | COAD | 1 |
p.M47K | SKCM | 1 |
p.S396P | UCEC | 1 |
p.D328Y | UCEC | 1 |
p.R40X | SKCM | 1 |
p.K347T | ESCA | 1 |
p.L131F | SKCM | 1 |
p.T83A | PAAD | 1 |
p.G552R | SKCM | 1 |
p.S629L | SKCM | 1 |
p.Q113H | STAD | 1 |
p.Q675H | LUAD | 1 |
p.G446E | SKCM | 1 |
p.E228K | OV | 1 |
p.C180X | SKCM | 1 |
p.G414E | SKCM | 1 |
p.D252N | SKCM | 1 |
p.L605* | SKCM | 1 |
p.R642H | COAD | 1 |
p.S315L | SKCM | 1 |
p.E378D | BRCA | 1 |
p.R192C | ACC | 1 |
p.T603M | COAD | 1 |
p.D252Y | THCA | 1 |
p.I656V | PAAD | 1 |
p.I522M | STAD | 1 |
p.L89F | HNSC | 1 |
p.D342N | UCEC | 1 |
p.H658Y | SKCM | 1 |
p.D384N | SKCM | 1 |
p.T646M | COAD | 1 |
p.Q487E | BLCA | 1 |
p.E494K | BLCA | 1 |
p.D576N | OV | 1 |
p.T554N | SKCM | 1 |
p.E491X | ESCA | 1 |
p.T680I | SKCM | 1 |
p.A639V | COAD | 1 |
p.L299I | UCEC | 1 |
p.E378* | UCEC | 1 |
p.D374N | KIRP | 1 |
p.E102Q | BLCA | 1 |
p.V149I | UCEC | 1 |
p.P567L | LUAD | 1 |
p.D355N | SKCM | 1 |
p.R40* | SKCM | 1 |
p.G388W | SKCM | 1 |
p.M529L | KIRP | 1 |
p.N175K | SKCM | 1 |
p.Q236K | LUSC | 1 |
p.P339S | LIHC | 1 |
p.S456F | SKCM | 1 |
p.T257I | COAD | 1 |
p.P655L | STAD | 1 |
p.D252N | LUSC | 1 |
p.I86M | HNSC | 1 |
p.V621M | UCEC | 1 |
p.R242C | OV | 1 |
p.R242C | UCEC | 1 |
p.D512E | LGG | 1 |
p.I288F | KICH | 1 |
p.L222Q | KIRC | 1 |
p.E659K | BLCA | 1 |
p.L606V | STAD | 1 |
p.R40X | CHOL | 1 |
p.L56F | BRCA | 1 |
p.Q293P | KIRC | 1 |
p.S306Y | UCEC | 1 |
p.E132K | LIHC | 1 |
p.C180* | SKCM | 1 |
p.E378D | STAD | 1 |
p.G581C | STAD | 1 |
p.A197V | STAD | 1 |
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TissGeneCNV for CCDC62 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC62 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC62 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC62 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC62 |
TissGeneDrug for CCDC62 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC62 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0030567 | Parkinson Disease | 3 | BeFree,GAD,GWASCAT |
umls:C1858712 | Spastic paraplegia 10, autosomal dominant | 2 | BeFree |
umls:C0013421 | Dystonia | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0270736 | Essential Tremor | 1 | BeFree |
umls:C0282527 | Infantile Refsum Disease (disorder) | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0393593 | Dystonia Disorders | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |