TissGeneSummary for ABHD1 |
Gene summary |
Basic gene information | Gene symbol | ABHD1 |
Gene name | abhydrolase domain containing 1 | |
Synonyms | LABH1 | |
Cytomap | UCSC genome browser: 2p23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_032604.3, NM_152870.1, | |
Description | abhydrolase domain-containing protein 1lung alpha/beta hydrolase 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612195 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143994 | ||
HPRD : 07468 | ||
Vega : OTTHUMG00000097072 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ABHD1 | |
BioGPS: 84696 | ||
Pathway | NCI Pathway Interaction Database: ABHD1 | |
KEGG: ABHD1 | ||
REACTOME: ABHD1 | ||
Pathway Commons: ABHD1 | ||
Context | iHOP: ABHD1 | |
ligand binding site mutation search in PubMed: ABHD1 | ||
UCL Cancer Institute: ABHD1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ABHD1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ABHD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.471853259 | 1.527098741 | -1.998952 | 2.08E-06 | 7.43E-06 |
BRCA | 1.048975969 | 2.059040004 | -1.010064035 | 1.46E-12 | 6.49E-12 |
LIHC | 1.954170741 | 3.113242741 | -1.159072 | 0.00132 | 0.003540725 |
HNSC | -1.299323399 | 0.079655671 | -1.37897907 | 0.000218 | 0.000883784 |
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TissGene-miRNA for ABHD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ABHD1 |
TissGeneSNV for ABHD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D15Y | THYM | 1 |
p.S345P | CHOL | 1 |
p.Q91H | HNSC | 1 |
p.L29F | BLCA | 1 |
p.A396D | LUAD | 1 |
p.P244S | LUAD | 1 |
p.Q218H | LUAD | 1 |
p.S293C | UCEC | 1 |
p.G161S | SKCM | 1 |
p.L258F | PAAD | 1 |
p.V80A | STAD | 1 |
p.L127R | PRAD | 1 |
p.P196A | SKCM | 1 |
p.S3N | STAD | 1 |
p.D137Y | HNSC | 1 |
p.E53K | LUAD | 1 |
p.P46S | SKCM | 1 |
p.L228M | LUAD | 1 |
p.A349V | LUAD | 1 |
p.R282C | COAD | 1 |
p.Q96K | LIHC | 1 |
p.S405R | LUAD | 1 |
p.S345F | SKCM | 1 |
p.I314R | HNSC | 1 |
p.R318W | BLCA | 1 |
p.L143P | BRCA | 1 |
p.G130V | STAD | 1 |
p.L397I | UCEC | 1 |
p.S229F | HNSC | 1 |
p.Q47* | LGG | 1 |
p.W371C | COAD | 1 |
p.S113N | STAD | 1 |
p.C174F | BLCA | 1 |
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TissGeneCNV for ABHD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ABHD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ABHD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ABHD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ABHD1 |
TissGeneDrug for ABHD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ABHD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |