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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ORAI1
check button Gene summary
Basic gene informationGene symbolORAI1
Gene nameORAI calcium release-activated calcium modulator 1
SynonymsCRACM1|IMD9|ORAT1|TAM2|TMEM142A
CytomapUCSC genome browser: 12q24.31
Type of geneprotein-coding
RefGenesNM_032790.3,
Descriptioncalcium release-activated calcium channel protein 1calcium release-activated calcium modulator 1protein orai-1transmembrane protein 142A
Modification date20141221
dbXrefs MIM : 610277
HGNC : HGNC
HPRD : 08599
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ORAI1
BioGPS: 84876
PathwayNCI Pathway Interaction Database: ORAI1
KEGG: ORAI1
REACTOME: ORAI1
Pathway Commons: ORAI1
ContextiHOP: ORAI1
ligand binding site mutation search in PubMed: ORAI1
UCL Cancer Institute: ORAI1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)OvarySkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)OVSKCM
Reference showing the relevant tissue of ORAI1
Description by TissGene annotationsHave significant anti-correlated miRNA
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0051928positive regulation of calcium ion transport16645049
GO:0051928positive regulation of calcium ion transport16645049


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TissGeneExp for ORAI1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for ORAI1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-106b-5pMIMAT00006800.029-0.2956
LUADhsa-miR-20b-5pMIMAT00014130.0054-0.3660


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TissGeneMut for ORAI1
TissGeneSNV for ORAI1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.H288QHNSC1
p.A238TLUAD1
p.V255IUCEC1
p.P295LSKCM1
p.G185DGBM1
p.M106VLAML1
p.H290QHNSC1
p.A113TSTAD1
p.G247SHNSC1
p.T214NHNSC1
p.G249SHNSC1
p.A282VGBM1
p.E277DCOAD1
p.A237VCHOL1
p.S50CLUAD1
p.V226FESCA1
p.R169LLUAD1
p.S181FSKCM1
p.A111TSTAD1
p.P44ALIHC1
p.S48CLUAD1
p.R270QUCEC1
p.A279STHYM1
p.A240TLUAD1
p.R268QUCEC1
p.S159LUCEC1


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TissGeneCNV for ORAI1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ORAI1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanUCECTCGA-D1-A3DG-01ATMEM120B-ORAI1Out-of-Framechr12:122199644chr12:122078946


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TissGeneNet for ORAI1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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COAD (tumor)COAD (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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HNSC (tumor)HNSC (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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KICH (tumor)KICH (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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KIRC (tumor)KIRC (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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KIRP (tumor)KIRP (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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LIHC (tumor)LIHC (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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LUAD (tumor)LUAD (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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LUSC (tumor)LUSC (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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PRAD (tumor)PRAD (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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STAD (tumor)STAD (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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THCA (tumor)THCA (normal)
ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (tumor)ORAI1, TRPC1, STIM1, TRPC3, TRPC6, TMEM66, EFCAB4B, ATP2C2, ORAI3 (normal)
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TissGeneProg for ORAI1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ORAI1
TissGeneDrug for ORAI1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ORAI1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019693HIV Infections6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0085110Severe Combined Immunodeficiency5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0017636Glioblastoma3BeFree
umls:C0025202melanoma3BeFree
umls:C0020538Hypertensive disease2BeFree,CTD_human
umls:C0021051Immunologic Deficiency Syndromes2BeFree
umls:C0027627Neoplasm Metastasis2BeFree,LHGDN
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0392525Nephrolithiasis2BeFree
umls:C0410207Tubular Aggregate Myopathy2BeFree,ORPHANET
umls:C0600139Prostate carcinoma2BeFree
umls:C1621958Glioblastoma Multiforme2BeFree
umls:C1706004Anhydrotic Ectodermal Dysplasias2BeFree
umls:C0004364Autoimmune Diseases1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0013595Eczema1BeFree
umls:C0017638Glioma1BeFree
umls:C0018133Graft-vs-Host Disease1BeFree
umls:C0024314Lymphoproliferative Disorders1BeFree
umls:C0026691Mucocutaneous Lymph Node Syndrome1BeFree
umls:C0026827Muscle hypotonia1BeFree
umls:C0026850Muscular Dystrophy1BeFree
umls:C0038013Ankylosing spondylitis1BeFree
umls:C0041341Tuberous Sclerosis1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0524702Pulmonary Thromboembolisms1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0858252Breast adenocarcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1708565Invasive Skin Melanoma1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C1846064Recurrent infections (sinusitis and bacterial pneumonia and meningitis)1BeFree
umls:C2748557Immune dysfunction with T-cell inactivation due to calcium entry defect 21BeFree
umls:C2748568Immune dysfunction with T-cell inactivation due to calcium entry defect 11CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C4014557MYOPATHY, TUBULAR AGGREGATE, 21UNIPROT