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TissGeneSummary for AIFM2 |
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Basic gene information | Gene symbol | AIFM2 |
Gene name | apoptosis-inducing factor, mitochondrion-associated, 2 | |
Synonyms | AMID|PRG3 | |
Cytomap | UCSC genome browser: 10q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_032797.5, NM_001198696.1, | |
Description | apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of deathapoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of deathapoptosis-inducing factor 2p53-responsive gene 3 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 605159 | |
HGNC : HGNC | ||
Ensembl : ENSG00000042286 | ||
HPRD : 09797 | ||
Vega : OTTHUMG00000018398 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AIFM2 | |
BioGPS: 84883 | ||
Pathway | NCI Pathway Interaction Database: AIFM2 | |
KEGG: AIFM2 | ||
REACTOME: AIFM2 | ||
Pathway Commons: AIFM2 | ||
Context | iHOP: AIFM2 | |
ligand binding site mutation search in PubMed: AIFM2 | ||
UCL Cancer Institute: AIFM2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastCervix | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCACESC | |
Reference showing the relevant tissue of AIFM2 | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0008637 | apoptotic mitochondrial changes | 11980907 | GO:0043065 | positive regulation of apoptotic process | 11980907 | GO:0008637 | apoptotic mitochondrial changes | 11980907 | GO:0043065 | positive regulation of apoptotic process | 11980907 |
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TissGeneExp for AIFM2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.539635496 | 1.137434679 | -1.677070175 | 3.70E-26 | 3.90E-25 |
PRAD | -1.254781346 | -0.180715962 | -1.074065385 | 1.30E-17 | 3.24E-15 |
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TissGene-miRNA for AIFM2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AIFM2 |
TissGeneSNV for AIFM2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G117D | PAAD | 1 |
p.S362C | BLCA | 1 |
p.L241V | BLCA | 1 |
p.I85V | LGG | 1 |
p.R143Q | UCEC | 1 |
p.A180T | UCEC | 1 |
p.V306M | STAD | 1 |
p.A295D | UCEC | 1 |
p.S258N | OV | 1 |
p.V122F | BLCA | 1 |
p.S187F | LUSC | 1 |
p.P101L | SKCM | 1 |
p.R208W | CESC | 1 |
p.G113V | LUAD | 1 |
p.V82L | LUAD | 1 |
p.P166L | ESCA | 1 |
p.A108T | UCEC | 1 |
p.E219A | UCEC | 1 |
p.G154E | SKCM | 1 |
p.A320T | PAAD | 1 |
p.M135T | COAD | 1 |
p.P101S | SKCM | 1 |
p.V35I | UCEC | 1 |
p.L318V | BRCA | 1 |
p.N218S | STAD | 1 |
p.R54Q | UCEC | 1 |
p.H104Y | BLCA | 1 |
p.T236S | SKCM | 1 |
p.T327M | HNSC | 1 |
p.S68F | BRCA | 1 |
p.D86Y | READ | 1 |
p.V146M | UCEC | 1 |
p.S152L | DLBC | 1 |
p.V289M | UCEC | 1 |
p.R316Q | PRAD | 1 |
p.P323L | KIRP | 1 |
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TissGeneCNV for AIFM2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AIFM2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AV704263 | AIFM2-GAS7 | chr10:71873495 | chr17:9817154 | |
Chimerdb3.0 | ChiTaRs | NA | CB164713 | AIFM2-AIFM2 | chr10:71892565 | chr10:71873742 |
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TissGeneNet for AIFM2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AIFM2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AIFM2 |
TissGeneDrug for AIFM2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AIFM2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree,GAD |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |