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| TissGeneSummary for MAEL |
 Gene summary |
| Basic gene information | Gene symbol | MAEL |
| Gene name | maelstrom spermatogenic transposon silencer | |
| Synonyms | CT128|SPATA35 | |
| Cytomap | UCSC genome browser: 1q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001286377.1, NM_001286378.1,NM_032858.2, | |
| Description | cancer/testis antigen 128maelstrom homologprotein maelstrom homologspermatogenesis associated 35 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611368 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143194 | ||
| HPRD : 08609 | ||
| Vega : OTTHUMG00000034432 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAEL | |
| BioGPS: 84944 | ||
| Pathway | NCI Pathway Interaction Database: MAEL | |
| KEGG: MAEL | ||
| REACTOME: MAEL | ||
| Pathway Commons: MAEL | ||
| Context | iHOP: MAEL | |
| ligand binding site mutation search in PubMed: MAEL | ||
| UCL Cancer Institute: MAEL | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of MAEL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MAEL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.101736301 | 0.475067699 | -3.576804 | 2.21E-13 | 2.93E-12 |
| LUAD | -1.326385612 | -2.345082163 | 1.018696552 | 0.00261 | 0.005331721 |
| BLCA | -2.488277354 | -1.119282617 | -1.368994737 | 0.000497 | 0.004063706 |
| PRAD | -1.049777455 | 0.041005237 | -1.090782692 | 0.000909 | 0.002978171 |
| LIHC | -0.487534301 | -2.073658301 | 1.586124 | 0.000244 | 0.000769778 |
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| TissGene-miRNA for MAEL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MAEL |
| TissGeneSNV for MAEL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E162K | SKCM | 3 |
| p.S41A | PCPG | 3 |
| p.R168* | SKCM | 2 |
| p.R267Q | SKCM | 2 |
| p.R59* | UCEC | 2 |
| p.S416L | SKCM | 2 |
| p.E21K | SKCM | 2 |
| p.R267X | READ | 2 |
| p.P182S | SKCM | 2 |
| p.V388I | BRCA | 1 |
| p.Q254* | SKCM | 1 |
| p.W285S | LUAD | 1 |
| p.I306M | HNSC | 1 |
| p.A273V | UCEC | 1 |
| p.S403Y | UCEC | 1 |
| p.R378K | SKCM | 1 |
| p.R389W | COAD | 1 |
| p.R267* | SKCM | 1 |
| p.L310M | UCEC | 1 |
| p.A343E | LUSC | 1 |
| p.S122I | HNSC | 1 |
| p.T221A | BRCA | 1 |
| p.L82Q | SKCM | 1 |
| p.S386R | ESCA | 1 |
| p.S357C | SKCM | 1 |
| p.M87I | LUAD | 1 |
| p.S418L | SKCM | 1 |
| p.A63T | SKCM | 1 |
| p.R389W | UCEC | 1 |
| p.F202C | STAD | 1 |
| p.S361T | LUAD | 1 |
| p.F356L | UCEC | 1 |
| p.A303V | HNSC | 1 |
| p.N412K | PAAD | 1 |
| p.G426A | HNSC | 1 |
| p.V388I | STAD | 1 |
| p.P71L | LUAD | 1 |
| p.R267X | COAD | 1 |
| p.R8L | COAD | 1 |
| p.L110V | BLCA | 1 |
| p.R267X | STAD | 1 |
| p.E246Q | BLCA | 1 |
| p.S145F | BRCA | 1 |
| p.R378M | LUAD | 1 |
| p.G66E | CESC | 1 |
| p.S40P | LIHC | 1 |
| p.F430L | UCEC | 1 |
| p.R168X | SKCM | 1 |
| p.R133P | LUAD | 1 |
| p.E17K | SKCM | 1 |
| p.E138K | SKCM | 1 |
| p.H204D | CESC | 1 |
| p.E187K | SKCM | 1 |
| p.A101T | UCEC | 1 |
| p.N412K | BLCA | 1 |
| p.P136H | ACC | 1 |
| p.R345C | COAD | 1 |
| p.L417F | SKCM | 1 |
| p.F410L | UCS | 1 |
| p.R267* | UCEC | 1 |
| p.R59Q | SKCM | 1 |
| p.F257C | SKCM | 1 |
| p.C299F | THYM | 1 |
| p.L292P | UCS | 1 |
| p.G355E | SKCM | 1 |
| p.L258I | KIRP | 1 |
| p.A174T | CESC | 1 |
| p.R168X | READ | 1 |
| p.R267* | STAD | 1 |
| p.F13L | COAD | 1 |
| p.L258I | READ | 1 |
| p.E288* | UCEC | 1 |
| p.K380N | SKCM | 1 |
| p.L243R | LUAD | 1 |
| p.D271N | UCEC | 1 |
| p.F154L | STAD | 1 |
| p.R59* | SKCM | 1 |
| p.R8Q | STAD | 1 |
| p.R350M | HNSC | 1 |
| p.E50K | SKCM | 1 |
| p.L310V | BLCA | 1 |
| p.E48K | SKCM | 1 |
| p.C141Y | UCS | 1 |
| p.S309Y | UCEC | 1 |
| p.R168* | BLCA | 1 |
| p.L243R | ESCA | 1 |
| p.Y54H | BLCA | 1 |
| p.S361Y | COAD | 1 |
| p.S309A | UCEC | 1 |
| p.L258I | UCS | 1 |
| p.S41A | BRCA | 1 |
| p.E365* | LUAD | 1 |
| p.Q75K | LUAD | 1 |
| p.A303_splice | UCEC | 1 |
| p.R345H | PAAD | 1 |
| p.Q172L | LUSC | 1 |
| p.R188S | LUAD | 1 |
| p.D342V | LGG | 1 |
| p.L258F | SKCM | 1 |
| p.N406S | LUSC | 1 |
| p.R165Q | CHOL | 1 |
| p.Y346C | SKCM | 1 |
| p.C294W | SKCM | 1 |
| p.I139T | LAML | 1 |
| p.G315E | SKCM | 1 |
| p.R24Q | LIHC | 1 |
| p.R378S | LUAD | 1 |
| p.E21K | UCEC | 1 |
| p.P261L | SKCM | 1 |
| p.S382F | SKCM | 1 |
| p.M274L | LIHC | 1 |
| p.E60* | UCEC | 1 |
| p.G113S | SKCM | 1 |
| p.G373_splice | LUSC | 1 |
| p.P96L | THYM | 1 |
| p.I213V | LGG | 1 |
| p.I400V | LIHC | 1 |
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| TissGeneCNV for MAEL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MAEL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-2H-A9GG-01A | POU2F1-MAEL | In-Frame | chr1:167190195 | chr1:166973416 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A0TT-01A | UBE2Q1-MAEL | Out-of-frame | Chr1:154525212 | Chr1:166974313 |
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| TissGeneNet for MAEL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MAEL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MAEL |
| TissGeneDrug for MAEL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MAEL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0029456 | Osteoporosis | 1 | GAD |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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