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| TissGeneSummary for AJUBA |
 Gene summary |
| Basic gene information | Gene symbol | AJUBA |
| Gene name | ajuba LIM protein | |
| Synonyms | JUB | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289097.1, NM_032876.5,NM_198086.2, | |
| Description | LIM domain-containing protein ajubajub, ajuba homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609066 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129474 | ||
| HPRD : 16426 | ||
| Vega : OTTHUMG00000028711 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AJUBA | |
| BioGPS: 84962 | ||
| Pathway | NCI Pathway Interaction Database: AJUBA | |
| KEGG: AJUBA | ||
| REACTOME: AJUBA | ||
| Pathway Commons: AJUBA | ||
| Context | iHOP: AJUBA | |
| ligand binding site mutation search in PubMed: AJUBA | ||
| UCL Cancer Institute: AJUBA | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLiverSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLIHCSKCM | |
| Reference showing the relevant tissue of AJUBA | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0001666 | response to hypoxia | 22286099 | GO:0031334 | positive regulation of protein complex assembly | 15870274 | GO:0035331 | negative regulation of hippo signaling | 20303269 | GO:1900037 | regulation of cellular response to hypoxia | 22286099 | GO:0001666 | response to hypoxia | 22286099 | GO:0031334 | positive regulation of protein complex assembly | 15870274 | GO:0035331 | negative regulation of hippo signaling | 20303269 | GO:1900037 | regulation of cellular response to hypoxia | 22286099 |
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| TissGeneExp for AJUBA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for AJUBA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-500b-5p | MIMAT0016925 | 0.02 | -0.27 | 78 |
| ACC | hsa-miR-500b-5p | MIMAT0016925 | 0.02 | -0.27 | 78 |
| ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.0094 | -0.29 | 78 |
| ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.0094 | -0.29 | 78 |
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| TissGeneMut for AJUBA |
| TissGeneSNV for AJUBA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q103* | HNSC | 2 |
| p.E311X | ESCA | 1 |
| p.E279* | HNSC | 1 |
| p.P301L | SKCM | 1 |
| p.G245V | LUAD | 1 |
| p.T30I | SKCM | 1 |
| p.G467C | SKCM | 1 |
| p.N433I | HNSC | 1 |
| p.E311* | ESCA | 1 |
| p.Q76* | HNSC | 1 |
| p.R487Q | STAD | 1 |
| p.R428Q | HNSC | 1 |
| p.N433S | PRAD | 1 |
| p.G32V | STAD | 1 |
| p.H423Y | HNSC | 1 |
| p.R428* | HNSC | 1 |
| p.D390N | BLCA | 1 |
| p.R10H | LGG | 1 |
| p.A354V | BLCA | 1 |
| p.G299* | LUAD | 1 |
| p.V480M | COAD | 1 |
| p.A274T | LGG | 1 |
| p.Q353* | HNSC | 1 |
| p.E2* | BLCA | 1 |
| p.C426Y | HNSC | 1 |
| p.H360Y | HNSC | 1 |
| p.R371* | CESC | 1 |
| p.P424T | BLCA | 1 |
| p.R293* | HNSC | 1 |
| p.S504R | UCEC | 1 |
| p.D390H | CESC | 1 |
| p.A52D | SARC | 1 |
| p.G296R | COAD | 1 |
| p.F396I | LUAD | 1 |
| p.G419E | GBM | 1 |
| p.E401Q | BLCA | 1 |
| p.C406S | HNSC | 1 |
| p.Q362* | HNSC | 1 |
| p.G296R | ACC | 1 |
| p.Y231X | LIHC | 1 |
| p.R371* | HNSC | 1 |
| p.Q76* | CESC | 1 |
| p.L358V | MESO | 1 |
| p.G43E | BLCA | 1 |
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| TissGeneCNV for AJUBA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AJUBA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for AJUBA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for AJUBA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AJUBA |
| TissGeneDrug for AJUBA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AJUBA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0027832 | Neurofibromatosis 2 | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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