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| TissGeneSummary for FAM83A |
 Gene summary |
| Basic gene information | Gene symbol | FAM83A |
| Gene name | family with sequence similarity 83, member A | |
| Synonyms | BJ-TSA-9 | |
| Cytomap | UCSC genome browser: 8q24.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001288587.1, NM_032899.5,NM_207006.2, | |
| Description | protein FAM83Atumor antigen BJ-TSA-9tumor-specific gene expressed in prostate protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000147689 | ||
| HPRD : 17489 | ||
| Vega : OTTHUMG00000165083 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FAM83A | |
| BioGPS: 84985 | ||
| Pathway | NCI Pathway Interaction Database: FAM83A | |
| KEGG: FAM83A | ||
| REACTOME: FAM83A | ||
| Pathway Commons: FAM83A | ||
| Context | iHOP: FAM83A | |
| ligand binding site mutation search in PubMed: FAM83A | ||
| UCL Cancer Institute: FAM83A | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAPRAD | |
| Reference showing the relevant tissue of FAM83A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FAM83A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 2.892328609 | -1.764012567 | 4.656341176 | 1.62E-14 | 9.26E-14 |
| LUAD | 4.816260286 | -1.613013852 | 6.429274138 | 4.45E-37 | 2.00E-34 |
| HNSC | 6.325052868 | 5.064392403 | 1.260660465 | 0.0185 | 0.041541916 |
| BRCA | -1.109642134 | -2.179317573 | 1.069675439 | 0.000435 | 0.00088893 |
| PRAD | -3.998963322 | -1.950622937 | -2.048340385 | 2.63E-05 | 0.000130107 |
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| TissGene-miRNA for FAM83A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FAM83A |
| TissGeneSNV for FAM83A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E131K | SKCM | 2 |
| p.S322N | THYM | 1 |
| p.A109V | OV | 1 |
| p.G264R | OV | 1 |
| p.G225E | SKCM | 1 |
| p.A237T | COAD | 1 |
| p.A351T | PAAD | 1 |
| p.A68V | SKCM | 1 |
| p.T158I | KIRP | 1 |
| p.T84N | BLCA | 1 |
| p.P344L | SKCM | 1 |
| p.R13H | LGG | 1 |
| p.V66L | LUAD | 1 |
| p.P361S | SKCM | 1 |
| p.R153H | OV | 1 |
| p.S327R | STAD | 1 |
| p.R268Q | SKCM | 1 |
| p.N146S | STAD | 1 |
| p.S133F | SKCM | 1 |
| p.D149N | SKCM | 1 |
| p.D212E | KIRC | 1 |
| p.Q195H | LUAD | 1 |
| p.F62L | COAD | 1 |
| p.A88V | UCEC | 1 |
| p.S97F | SKCM | 1 |
| p.S247L | SKCM | 1 |
| p.H362P | HNSC | 1 |
| p.G311R | SKCM | 1 |
| p.V142D | BRCA | 1 |
| p.A90V | SKCM | 1 |
| p.R250K | SKCM | 1 |
| p.W376* | SKCM | 1 |
| p.E180* | LUAD | 1 |
| p.G196E | SKCM | 1 |
| p.S247L | COAD | 1 |
| p.H362P | TGCT | 1 |
| p.H362P | LUAD | 1 |
| p.E284K | LUSC | 1 |
| p.R287C | LGG | 1 |
| p.T158P | KIRP | 1 |
| p.S133P | STAD | 1 |
| p.G196R | SKCM | 1 |
| p.W121X | SKCM | 1 |
| p.S99F | SKCM | 1 |
| p.S352F | SKCM | 1 |
| p.Q69R | PCPG | 1 |
| p.P309S | SKCM | 1 |
| p.M166I | READ | 1 |
| p.C80S | LUAD | 1 |
| p.R221W | SKCM | 1 |
| p.A291T | SKCM | 1 |
| p.A351V | PRAD | 1 |
| p.E131K | HNSC | 1 |
| p.W121* | SKCM | 1 |
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| TissGeneCNV for FAM83A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FAM83A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW365300 | FAM83A-WDR91 | chr8:124221625 | chr7:134872296 | |
| Chimerdb3.0 | ChiTaRs | NA | AF497803 | FAM83A-FAM83A | chr8:124195571 | chr8:124194921 |
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| TissGeneNet for FAM83A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FAM83A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FAM83A |
| TissGeneDrug for FAM83A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FAM83A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024121 | Lung Neoplasms | 2 | LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
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