 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for PIK3R3 |
 Gene summary |
| Basic gene information | Gene symbol | PIK3R3 |
| Gene name | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | |
| Synonyms | p55|p55-GAMMA | |
| Cytomap | UCSC genome browser: 1p34.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001114172.1, NM_003629.3, | |
| Description | 100% homology to SWISS-PROT Q92569PI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammap55PIKphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase regulatory subunit gammap | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606076 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000117461 | ||
| HPRD : 05831 | ||
| Vega : OTTHUMG00000008096 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIK3R3 | |
| BioGPS: 8503 | ||
| Pathway | NCI Pathway Interaction Database: PIK3R3 | |
| KEGG: PIK3R3 | ||
| REACTOME: PIK3R3 | ||
| Pathway Commons: PIK3R3 | ||
| Context | iHOP: PIK3R3 | |
| ligand binding site mutation search in PubMed: PIK3R3 | ||
| UCL Cancer Institute: PIK3R3 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATGCT | |
| Reference showing the relevant tissue of PIK3R3 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for PIK3R3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for PIK3R3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUSC | hsa-miR-323a-3p | MIMAT0000755 | 0.0018 | -0.28 | 128 |
| UCS | hsa-miR-148a-3p | MIMAT0000243 | 0.042 | -0.28 | 56 |
| LUAD | hsa-miR-181d-5p | MIMAT0002821 | 0.019 | -0.31 | 60 |
| Top |
| TissGeneMut for PIK3R3 |
| TissGeneSNV for PIK3R3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L326R | BRCA | 2 |
| p.V396A | READ | 1 |
| p.E25* | UCEC | 1 |
| p.C404R | ACC | 1 |
| p.K293T | UCEC | 1 |
| p.S265L | SKCM | 1 |
| p.E385K | CESC | 1 |
| p.E228K | SKCM | 1 |
| p.E239X | READ | 1 |
| p.R306Q | READ | 1 |
| p.A383G | CESC | 1 |
| p.S319T | UCEC | 1 |
| p.P127L | LUAD | 1 |
| p.E201K | LUAD | 1 |
| p.E217K | PAAD | 1 |
| p.P85R | CESC | 1 |
| p.V366A | ESCA | 1 |
| p.V446I | UCEC | 1 |
| p.K293T | STAD | 1 |
| p.D126H | COAD | 1 |
| p.H431Y | SKCM | 1 |
| p.V49F | COAD | 1 |
| p.M45V | PRAD | 1 |
| p.D99H | BLCA | 1 |
| p.R245C | SKCM | 1 |
| p.R276H | BLCA | 1 |
| p.E369K | HNSC | 1 |
| p.R383C | READ | 1 |
| p.E171* | UCEC | 1 |
| p.Q284H | UCEC | 1 |
| p.E239* | UCEC | 1 |
| p.A368V | BRCA | 1 |
| p.L37I | SARC | 1 |
| p.R411L | LUSC | 1 |
| p.G414D | READ | 1 |
| p.F380L | LUAD | 1 |
| p.T203A | LIHC | 1 |
| p.R383C | STAD | 1 |
| p.H231D | BLCA | 1 |
| p.M295T | LUAD | 1 |
| p.R90Q | HNSC | 1 |
| p.Q479K | GBM | 1 |
| p.L425V | BLCA | 1 |
| p.R355* | LUSC | 1 |
| p.S273T | UCEC | 1 |
| p.L83F | CESC | 1 |
| p.G378A | BLCA | 1 |
| Top |
| TissGeneCNV for PIK3R3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for PIK3R3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE515277 | UQCRH-PIK3R3 | chr1:46775989 | chr1:46519492 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-AASX-11A | UQCRH-PIK3R3 | In-Frame | chr1:46775988 | chr1:46527743 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-C8-A135-01A | PIK3R3-RAD54L | Out-of-Frame | chr1:46546313 | chr1:46733348 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A5D7-01A | PIK3R3-LRRC41 | Out-of-frame | Chr1:46527601 | Chr1:46747057 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7414-01A | PIK3R3-ZSWIM5 | In-frame | Chr1:46597519 | Chr1:45553909 |
| Top |
| TissGeneNet for PIK3R3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PIK3R3, DSN1, IRS1, LUC7L2, PDGFRB, INSR, DARS, IRS2, ERBB3, PSME1, KARS, CD19, TEC, MBIP, PIK3CD, AXL, MICAL1, VBP1, QARS, ORM1, SERF1A (tumor) | PIK3R3, KLC2, RING1, ERBB2, ESR1, KHDRBS1, GC, IRS1, LUC7L2, IRS2, PIK3CA, ERBB3, KARS, KIAA1377, MICAL1, FGB, ABCB6, TRMT2A, DRAP1, FBN3, SERF1A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PIK3R3, KLC2, HNF4A, ERBB2, ESR1, KHDRBS1, DSN1, EGFR, ABI1, LUC7L2, PDGFRB, IRS2, PIK3CA, ERBB3, TEC, AXL, AMBP, QARS, ABCB6, TRMT2A, ORM1 (tumor) | PIK3R3, HNF4A, ESR1, DSN1, IRS1, PDGFRB, DARS, IRS2, PIK3CA, ERBB3, KARS, CD19, KIAA1377, PIK3CD, AXL, MICAL1, QARS, TRMT2A, DRAP1, ORM1, SERF1A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PIK3R3, ERBB2, DSN1, ABI1, IGF1R, IRS1, PDGFRB, INSR, DARS, IRS2, CD19, KIAA1377, TEC, AXL, VBP1, AMBP, QARS, ABCB6, DRAP1, FBN3, SERF1A (tumor) | PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, IRS1, LUC7L2, INSR, DARS, IRS2, PIK3CA, ERBB3, KARS, CD19, MBIP, PIK3CD, QARS, DRAP1, FBN3, SERF1A (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PIK3R3, KLC2, HNF4A, RING1, ERBB2, ESR1, DSN1, EGFR, GC, IRS1, INSR, RB1, ERBB3, CD19, MICAL1, VBP1, FGB, ABCB6, ORM1, FBN3, SERF1A (tumor) | PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, IRS1, DARS, IRS2, ERBB3, PSME1, KARS, CD19, KIAA1377, TEC, VBP1, AMBP, FGB, QARS, TRMT2A, DRAP1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PIK3R3, KLC2, HNF4A, ESR1, KHDRBS1, DSN1, EGFR, GC, IGF1R, IRS1, INSR, DARS, RB1, ERBB3, PSME1, KARS, PIK3CD, AMBP, ABCB6, TRMT2A, FBN3 (tumor) | PIK3R3, KLC2, HNF4A, ESR1, KHDRBS1, DSN1, EGFR, IGF1R, PDGFRB, INSR, RB1, IRS2, PIK3CA, KARS, CD19, MBIP, MICAL1, QARS, TRMT2A, DRAP1, ORM1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PIK3R3, KLC2, HNF4A, RING1, ERBB2, ESR1, DSN1, ABI1, GC, IGF1R, IRS1, INSR, PIK3CA, ERBB3, PSME1, KARS, PIK3CD, FGB, ABCB6, DRAP1, ORM1 (tumor) | PIK3R3, KLC2, RING1, ERBB2, ESR1, EGFR, ABI1, IGF1R, IRS1, LUC7L2, PDGFRB, INSR, PIK3CA, PSME1, KARS, KIAA1377, AXL, VBP1, TRMT2A, DRAP1, FBN3 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PIK3R3, HNF4A, RING1, DSN1, ABI1, GC, IGF1R, PDGFRB, RB1, ERBB3, PSME1, CD19, KIAA1377, MBIP, PIK3CD, AXL, MICAL1, VBP1, AMBP, TRMT2A, SERF1A (tumor) | PIK3R3, RING1, ESR1, KHDRBS1, DSN1, EGFR, PDGFRB, DARS, RB1, PIK3CA, ERBB3, MBIP, PIK3CD, AXL, MICAL1, QARS, ABCB6, TRMT2A, DRAP1, FBN3, SERF1A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PIK3R3, RING1, EGFR, ABI1, IRS1, PDGFRB, INSR, RB1, IRS2, PIK3CA, PSME1, KARS, PIK3CD, AXL, MICAL1, AMBP, FGB, QARS, ABCB6, TRMT2A, DRAP1 (tumor) | PIK3R3, HNF4A, KHDRBS1, DSN1, EGFR, ABI1, LUC7L2, INSR, DARS, RB1, IRS2, PIK3CA, PSME1, CD19, KIAA1377, TEC, PIK3CD, VBP1, FGB, QARS, FBN3 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PIK3R3, KLC2, RING1, KHDRBS1, DSN1, EGFR, GC, LUC7L2, PDGFRB, INSR, DARS, RB1, ERBB3, CD19, TEC, MBIP, AXL, FGB, QARS, DRAP1, ORM1 (tumor) | PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, EGFR, ABI1, INSR, DARS, IRS2, PIK3CA, ERBB3, PSME1, KARS, CD19, KIAA1377, AXL, MICAL1, ABCB6, DRAP1, FBN3 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PIK3R3, RING1, ERBB2, KHDRBS1, DSN1, EGFR, GC, IGF1R, PDGFRB, RB1, IRS2, PIK3CA, PSME1, CD19, KIAA1377, PIK3CD, FGB, QARS, ABCB6, DRAP1, FBN3 (tumor) | PIK3R3, KLC2, RING1, ERBB2, EGFR, ABI1, IGF1R, IRS1, PDGFRB, RB1, IRS2, PIK3CA, PSME1, TEC, MBIP, VBP1, AMBP, QARS, ABCB6, TRMT2A, DRAP1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, ABI1, IRS1, LUC7L2, PDGFRB, INSR, DARS, IRS2, PIK3CA, ERBB3, KIAA1377, TEC, AXL, AMBP, QARS, ABCB6 (tumor) | PIK3R3, KLC2, RING1, ERBB2, ESR1, DSN1, PDGFRB, INSR, DARS, RB1, PIK3CA, ERBB3, KARS, CD19, PIK3CD, AMBP, FGB, ABCB6, TRMT2A, DRAP1, SERF1A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PIK3R3, KLC2, RING1, ERBB2, ESR1, KHDRBS1, DSN1, EGFR, ABI1, PDGFRB, INSR, RB1, IRS2, PSME1, KARS, TEC, MBIP, AXL, TRMT2A, FBN3, SERF1A (tumor) | PIK3R3, ERBB2, KHDRBS1, ABI1, IGF1R, IRS1, LUC7L2, PDGFRB, RB1, IRS2, ERBB3, PSME1, KARS, KIAA1377, TEC, PIK3CD, AXL, ABCB6, TRMT2A, FBN3, SERF1A (normal) |
 |  |
| Top |
| TissGeneProg for PIK3R3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for PIK3R3 |
| TissGeneDrug for PIK3R3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01064 | Isoprenaline | Agonist | Small molecule | Approved |
| Top |
| TissGeneDisease for PIK3R3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 8 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0035335 | Retinoblastoma | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C1522378 | Leukemia, Large Granular Lymphocytic | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0036202 | Sarcoidosis | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0553580 | Ewings sarcoma | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C0971858 | Arthritis, Collagen-Induced | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |