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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PIK3R3
check button Gene summary
Basic gene informationGene symbolPIK3R3
Gene namephosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Synonymsp55|p55-GAMMA
CytomapUCSC genome browser: 1p34.1
Type of geneprotein-coding
RefGenesNM_001114172.1,
NM_003629.3,
Description100% homology to SWISS-PROT Q92569PI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammap55PIKphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase regulatory subunit gammap
Modification date20141207
dbXrefs MIM : 606076
HGNC : HGNC
Ensembl : ENSG00000117461
HPRD : 05831
Vega : OTTHUMG00000008096
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PIK3R3
BioGPS: 8503
PathwayNCI Pathway Interaction Database: PIK3R3
KEGG: PIK3R3
REACTOME: PIK3R3
Pathway Commons: PIK3R3
ContextiHOP: PIK3R3
ligand binding site mutation search in PubMed: PIK3R3
UCL Cancer Institute: PIK3R3
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCATGCT
Reference showing the relevant tissue of PIK3R3
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PIK3R3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for PIK3R3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUSChsa-miR-323a-3pMIMAT00007550.0018-0.28128
UCShsa-miR-148a-3pMIMAT00002430.042-0.2856
LUADhsa-miR-181d-5pMIMAT00028210.019-0.3160


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TissGeneMut for PIK3R3
TissGeneSNV for PIK3R3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.L326RBRCA2
p.V396AREAD1
p.E25*UCEC1
p.C404RACC1
p.K293TUCEC1
p.S265LSKCM1
p.E385KCESC1
p.E228KSKCM1
p.E239XREAD1
p.R306QREAD1
p.A383GCESC1
p.S319TUCEC1
p.P127LLUAD1
p.E201KLUAD1
p.E217KPAAD1
p.P85RCESC1
p.V366AESCA1
p.V446IUCEC1
p.K293TSTAD1
p.D126HCOAD1
p.H431YSKCM1
p.V49FCOAD1
p.M45VPRAD1
p.D99HBLCA1
p.R245CSKCM1
p.R276HBLCA1
p.E369KHNSC1
p.R383CREAD1
p.E171*UCEC1
p.Q284HUCEC1
p.E239*UCEC1
p.A368VBRCA1
p.L37ISARC1
p.R411LLUSC1
p.G414DREAD1
p.F380LLUAD1
p.T203ALIHC1
p.R383CSTAD1
p.H231DBLCA1
p.M295TLUAD1
p.R90QHNSC1
p.Q479KGBM1
p.L425VBLCA1
p.R355*LUSC1
p.S273TUCEC1
p.L83FCESC1
p.G378ABLCA1


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TissGeneCNV for PIK3R3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PIK3R3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE515277UQCRH-PIK3R3chr1:46775989chr1:46519492
Chimerdb3.0FusionScanESCATCGA-V5-AASX-11AUQCRH-PIK3R3In-Framechr1:46775988chr1:46527743
Chimerdb3.0TopHat-FusionBRCATCGA-C8-A135-01APIK3R3-RAD54LOut-of-Framechr1:46546313chr1:46733348
TCGAfusionPortalPRADABRCATCGA-OL-A5D7-01APIK3R3-LRRC41Out-of-frameChr1:46527601Chr1:46747057
TCGAfusionPortalPRADAHNSCTCGA-CV-7414-01APIK3R3-ZSWIM5In-frameChr1:46597519Chr1:45553909


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TissGeneNet for PIK3R3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PIK3R3, DSN1, IRS1, LUC7L2, PDGFRB, INSR, DARS, IRS2, ERBB3, PSME1, KARS, CD19, TEC, MBIP, PIK3CD, AXL, MICAL1, VBP1, QARS, ORM1, SERF1A (tumor)PIK3R3, KLC2, RING1, ERBB2, ESR1, KHDRBS1, GC, IRS1, LUC7L2, IRS2, PIK3CA, ERBB3, KARS, KIAA1377, MICAL1, FGB, ABCB6, TRMT2A, DRAP1, FBN3, SERF1A (normal)
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COAD (tumor)COAD (normal)
PIK3R3, KLC2, HNF4A, ERBB2, ESR1, KHDRBS1, DSN1, EGFR, ABI1, LUC7L2, PDGFRB, IRS2, PIK3CA, ERBB3, TEC, AXL, AMBP, QARS, ABCB6, TRMT2A, ORM1 (tumor)PIK3R3, HNF4A, ESR1, DSN1, IRS1, PDGFRB, DARS, IRS2, PIK3CA, ERBB3, KARS, CD19, KIAA1377, PIK3CD, AXL, MICAL1, QARS, TRMT2A, DRAP1, ORM1, SERF1A (normal)
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HNSC (tumor)HNSC (normal)
PIK3R3, ERBB2, DSN1, ABI1, IGF1R, IRS1, PDGFRB, INSR, DARS, IRS2, CD19, KIAA1377, TEC, AXL, VBP1, AMBP, QARS, ABCB6, DRAP1, FBN3, SERF1A (tumor)PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, IRS1, LUC7L2, INSR, DARS, IRS2, PIK3CA, ERBB3, KARS, CD19, MBIP, PIK3CD, QARS, DRAP1, FBN3, SERF1A (normal)
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KICH (tumor)KICH (normal)
PIK3R3, KLC2, HNF4A, RING1, ERBB2, ESR1, DSN1, EGFR, GC, IRS1, INSR, RB1, ERBB3, CD19, MICAL1, VBP1, FGB, ABCB6, ORM1, FBN3, SERF1A (tumor)PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, IRS1, DARS, IRS2, ERBB3, PSME1, KARS, CD19, KIAA1377, TEC, VBP1, AMBP, FGB, QARS, TRMT2A, DRAP1 (normal)
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KIRC (tumor)KIRC (normal)
PIK3R3, KLC2, HNF4A, ESR1, KHDRBS1, DSN1, EGFR, GC, IGF1R, IRS1, INSR, DARS, RB1, ERBB3, PSME1, KARS, PIK3CD, AMBP, ABCB6, TRMT2A, FBN3 (tumor)PIK3R3, KLC2, HNF4A, ESR1, KHDRBS1, DSN1, EGFR, IGF1R, PDGFRB, INSR, RB1, IRS2, PIK3CA, KARS, CD19, MBIP, MICAL1, QARS, TRMT2A, DRAP1, ORM1 (normal)
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KIRP (tumor)KIRP (normal)
PIK3R3, KLC2, HNF4A, RING1, ERBB2, ESR1, DSN1, ABI1, GC, IGF1R, IRS1, INSR, PIK3CA, ERBB3, PSME1, KARS, PIK3CD, FGB, ABCB6, DRAP1, ORM1 (tumor)PIK3R3, KLC2, RING1, ERBB2, ESR1, EGFR, ABI1, IGF1R, IRS1, LUC7L2, PDGFRB, INSR, PIK3CA, PSME1, KARS, KIAA1377, AXL, VBP1, TRMT2A, DRAP1, FBN3 (normal)
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LIHC (tumor)LIHC (normal)
PIK3R3, HNF4A, RING1, DSN1, ABI1, GC, IGF1R, PDGFRB, RB1, ERBB3, PSME1, CD19, KIAA1377, MBIP, PIK3CD, AXL, MICAL1, VBP1, AMBP, TRMT2A, SERF1A (tumor)PIK3R3, RING1, ESR1, KHDRBS1, DSN1, EGFR, PDGFRB, DARS, RB1, PIK3CA, ERBB3, MBIP, PIK3CD, AXL, MICAL1, QARS, ABCB6, TRMT2A, DRAP1, FBN3, SERF1A (normal)
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LUAD (tumor)LUAD (normal)
PIK3R3, RING1, EGFR, ABI1, IRS1, PDGFRB, INSR, RB1, IRS2, PIK3CA, PSME1, KARS, PIK3CD, AXL, MICAL1, AMBP, FGB, QARS, ABCB6, TRMT2A, DRAP1 (tumor)PIK3R3, HNF4A, KHDRBS1, DSN1, EGFR, ABI1, LUC7L2, INSR, DARS, RB1, IRS2, PIK3CA, PSME1, CD19, KIAA1377, TEC, PIK3CD, VBP1, FGB, QARS, FBN3 (normal)
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LUSC (tumor)LUSC (normal)
PIK3R3, KLC2, RING1, KHDRBS1, DSN1, EGFR, GC, LUC7L2, PDGFRB, INSR, DARS, RB1, ERBB3, CD19, TEC, MBIP, AXL, FGB, QARS, DRAP1, ORM1 (tumor)PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, EGFR, ABI1, INSR, DARS, IRS2, PIK3CA, ERBB3, PSME1, KARS, CD19, KIAA1377, AXL, MICAL1, ABCB6, DRAP1, FBN3 (normal)
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PRAD (tumor)PRAD (normal)
PIK3R3, RING1, ERBB2, KHDRBS1, DSN1, EGFR, GC, IGF1R, PDGFRB, RB1, IRS2, PIK3CA, PSME1, CD19, KIAA1377, PIK3CD, FGB, QARS, ABCB6, DRAP1, FBN3 (tumor)PIK3R3, KLC2, RING1, ERBB2, EGFR, ABI1, IGF1R, IRS1, PDGFRB, RB1, IRS2, PIK3CA, PSME1, TEC, MBIP, VBP1, AMBP, QARS, ABCB6, TRMT2A, DRAP1 (normal)
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STAD (tumor)STAD (normal)
PIK3R3, KLC2, ERBB2, ESR1, KHDRBS1, DSN1, ABI1, IRS1, LUC7L2, PDGFRB, INSR, DARS, IRS2, PIK3CA, ERBB3, KIAA1377, TEC, AXL, AMBP, QARS, ABCB6 (tumor)PIK3R3, KLC2, RING1, ERBB2, ESR1, DSN1, PDGFRB, INSR, DARS, RB1, PIK3CA, ERBB3, KARS, CD19, PIK3CD, AMBP, FGB, ABCB6, TRMT2A, DRAP1, SERF1A (normal)
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THCA (tumor)THCA (normal)
PIK3R3, KLC2, RING1, ERBB2, ESR1, KHDRBS1, DSN1, EGFR, ABI1, PDGFRB, INSR, RB1, IRS2, PSME1, KARS, TEC, MBIP, AXL, TRMT2A, FBN3, SERF1A (tumor)PIK3R3, ERBB2, KHDRBS1, ABI1, IGF1R, IRS1, LUC7L2, PDGFRB, RB1, IRS2, ERBB3, PSME1, KARS, KIAA1377, TEC, PIK3CD, AXL, ABCB6, TRMT2A, FBN3, SERF1A (normal)
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TissGeneProg for PIK3R3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PIK3R3
TissGeneDrug for PIK3R3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB01064IsoprenalineAgonistSmall moleculeApproved


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TissGeneDisease for PIK3R3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019693HIV Infections8BeFree
umls:C0003873Rheumatoid Arthritis3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0035335Retinoblastoma2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C1522378Leukemia, Large Granular Lymphocytic2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007785Cerebral Infarction1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0017638Glioma1BeFree
umls:C0022116Ischemia1BeFree
umls:C0023418leukemia1BeFree
umls:C0024530Malaria1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0036202Sarcoidosis1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0376358Malignant neoplasm of prostate1GAD
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0553580Ewings sarcoma1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C0948380Colorectal cancer metastatic1BeFree
umls:C0971858Arthritis, Collagen-Induced1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree