TissGeneSummary for PIK3R3 |
Gene summary |
Basic gene information | Gene symbol | PIK3R3 |
Gene name | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | |
Synonyms | p55|p55-GAMMA | |
Cytomap | UCSC genome browser: 1p34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001114172.1, NM_003629.3, | |
Description | 100% homology to SWISS-PROT Q92569PI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammap55PIKphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase regulatory subunit gammap | |
Modification date | 20141207 | |
dbXrefs | MIM : 606076 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117461 | ||
HPRD : 05831 | ||
Vega : OTTHUMG00000008096 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PIK3R3 | |
BioGPS: 8503 | ||
Pathway | NCI Pathway Interaction Database: PIK3R3 | |
KEGG: PIK3R3 | ||
REACTOME: PIK3R3 | ||
Pathway Commons: PIK3R3 | ||
Context | iHOP: PIK3R3 | |
ligand binding site mutation search in PubMed: PIK3R3 | ||
UCL Cancer Institute: PIK3R3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATGCT | |
Reference showing the relevant tissue of PIK3R3 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PIK3R3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PIK3R3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUSC | hsa-miR-323a-3p | MIMAT0000755 | 0.0018 | -0.28 | 128 |
UCS | hsa-miR-148a-3p | MIMAT0000243 | 0.042 | -0.28 | 56 |
LUAD | hsa-miR-181d-5p | MIMAT0002821 | 0.019 | -0.31 | 60 |
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TissGeneMut for PIK3R3 |
TissGeneSNV for PIK3R3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L326R | BRCA | 2 |
p.V396A | READ | 1 |
p.E25* | UCEC | 1 |
p.C404R | ACC | 1 |
p.K293T | UCEC | 1 |
p.S265L | SKCM | 1 |
p.E385K | CESC | 1 |
p.E228K | SKCM | 1 |
p.E239X | READ | 1 |
p.R306Q | READ | 1 |
p.A383G | CESC | 1 |
p.S319T | UCEC | 1 |
p.P127L | LUAD | 1 |
p.E201K | LUAD | 1 |
p.E217K | PAAD | 1 |
p.P85R | CESC | 1 |
p.V366A | ESCA | 1 |
p.V446I | UCEC | 1 |
p.K293T | STAD | 1 |
p.D126H | COAD | 1 |
p.H431Y | SKCM | 1 |
p.V49F | COAD | 1 |
p.M45V | PRAD | 1 |
p.D99H | BLCA | 1 |
p.R245C | SKCM | 1 |
p.R276H | BLCA | 1 |
p.E369K | HNSC | 1 |
p.R383C | READ | 1 |
p.E171* | UCEC | 1 |
p.Q284H | UCEC | 1 |
p.E239* | UCEC | 1 |
p.A368V | BRCA | 1 |
p.L37I | SARC | 1 |
p.R411L | LUSC | 1 |
p.G414D | READ | 1 |
p.F380L | LUAD | 1 |
p.T203A | LIHC | 1 |
p.R383C | STAD | 1 |
p.H231D | BLCA | 1 |
p.M295T | LUAD | 1 |
p.R90Q | HNSC | 1 |
p.Q479K | GBM | 1 |
p.L425V | BLCA | 1 |
p.R355* | LUSC | 1 |
p.S273T | UCEC | 1 |
p.L83F | CESC | 1 |
p.G378A | BLCA | 1 |
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TissGeneCNV for PIK3R3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PIK3R3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE515277 | UQCRH-PIK3R3 | chr1:46775989 | chr1:46519492 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-AASX-11A | UQCRH-PIK3R3 | In-Frame | chr1:46775988 | chr1:46527743 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-C8-A135-01A | PIK3R3-RAD54L | Out-of-Frame | chr1:46546313 | chr1:46733348 |
TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A5D7-01A | PIK3R3-LRRC41 | Out-of-frame | Chr1:46527601 | Chr1:46747057 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7414-01A | PIK3R3-ZSWIM5 | In-frame | Chr1:46597519 | Chr1:45553909 |
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TissGeneNet for PIK3R3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PIK3R3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PIK3R3 |
TissGeneDrug for PIK3R3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01064 | Isoprenaline | Agonist | Small molecule | Approved |
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TissGeneDisease for PIK3R3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 8 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
umls:C0035335 | Retinoblastoma | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C1522378 | Leukemia, Large Granular Lymphocytic | 2 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007785 | Cerebral Infarction | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0022116 | Ischemia | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0036202 | Sarcoidosis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
umls:C0553580 | Ewings sarcoma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
umls:C0971858 | Arthritis, Collagen-Induced | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |