TissGeneSummary for CYP4F2 |
Gene summary |
Basic gene information | Gene symbol | CYP4F2 |
Gene name | cytochrome P450, family 4, subfamily F, polypeptide 2 | |
Synonyms | CPF2 | |
Cytomap | UCSC genome browser: 19p13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001082.4, | |
Description | 20-HETE synthase20-hydroxyeicosatetraenoic acid synthaseCYPIVF2arachidonic acid omega-hydroxylasecytochrome P450 4F2cytochrome P450, subfamily IVF, polypeptide 2cytochrome P450-LTB-omegaleukotriene-B(4) 20-monooxygenase 1leukotriene-B(4) omega-hyd | |
Modification date | 20141207 | |
dbXrefs | MIM : 604426 | |
HGNC : HGNC | ||
Ensembl : ENSG00000186115 | ||
HPRD : 05112 | ||
Vega : OTTHUMG00000185995 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYP4F2 | |
BioGPS: 8529 | ||
Pathway | NCI Pathway Interaction Database: CYP4F2 | |
KEGG: CYP4F2 | ||
REACTOME: CYP4F2 | ||
Pathway Commons: CYP4F2 | ||
Context | iHOP: CYP4F2 | |
ligand binding site mutation search in PubMed: CYP4F2 | ||
UCL Cancer Institute: CYP4F2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CYP4F2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000038 | very long-chain fatty acid metabolic process | 18433732 | GO:0001676 | long-chain fatty acid metabolic process | 18433732 | GO:0019369 | arachidonic acid metabolic process | 10660572 | GO:0019373 | epoxygenase P450 pathway | 20861217 | GO:0036101 | leukotriene B4 catabolic process | 10492403 | GO:0042360 | vitamin E metabolic process | 20861217 | GO:0042361 | menaquinone catabolic process | 24138531 | GO:0042376 | phylloquinone catabolic process | 24138531 | GO:0042377 | vitamin K catabolic process | 19297519 | GO:0055114 | oxidation-reduction process | 20861217 | GO:0000038 | very long-chain fatty acid metabolic process | 18433732 | GO:0001676 | long-chain fatty acid metabolic process | 18433732 | GO:0019369 | arachidonic acid metabolic process | 10660572 | GO:0019373 | epoxygenase P450 pathway | 20861217 | GO:0036101 | leukotriene B4 catabolic process | 10492403 | GO:0042360 | vitamin E metabolic process | 20861217 | GO:0042361 | menaquinone catabolic process | 24138531 | GO:0042376 | phylloquinone catabolic process | 24138531 | GO:0042377 | vitamin K catabolic process | 19297519 | GO:0055114 | oxidation-reduction process | 20861217 |
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TissGeneExp for CYP4F2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.611651802 | 2.550632198 | -5.162284 | 1.15E-07 | 5.24E-07 |
KIRC | -0.392854691 | 3.957753643 | -4.350608333 | 1.03E-11 | 4.01E-11 |
LIHC | 7.630968198 | 10.0400002 | -2.409032 | 4.48E-07 | 2.63E-06 |
KIRP | -1.397047052 | 5.195993573 | -6.593040625 | 9.51E-11 | 1.09E-09 |
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TissGene-miRNA for CYP4F2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CYP4F2 |
TissGeneSNV for CYP4F2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A483G | PCPG | 5 |
p.A483G | UVM | 3 |
p.G470R | STAD | 3 |
p.R57Q | SKCM | 2 |
p.R444C | SKCM | 2 |
p.R47H | UCEC | 2 |
p.D268N | SKCM | 2 |
p.R490C | BLCA | 1 |
p.V14L | BLCA | 1 |
p.R488H | ESCA | 1 |
p.A320S | PAAD | 1 |
p.R488H | LUAD | 1 |
p.D374N | SKCM | 1 |
p.E352Q | UCEC | 1 |
p.P442L | SKCM | 1 |
p.T250A | PCPG | 1 |
p.R515W | STAD | 1 |
p.A474P | LUSC | 1 |
p.Y39X | SKCM | 1 |
p.R353C | HNSC | 1 |
p.A113T | COAD | 1 |
p.P498S | THYM | 1 |
p.I422V | SKCM | 1 |
p.A118T | ESCA | 1 |
p.R149Q | STAD | 1 |
p.R507H | UCEC | 1 |
p.H401Y | ESCA | 1 |
p.A476V | GBM | 1 |
p.V433M | COAD | 1 |
p.M475K | LUSC | 1 |
p.P460L | HNSC | 1 |
p.R146H | PRAD | 1 |
p.I271M | OV | 1 |
p.L21P | LUSC | 1 |
p.R276H | LAML | 1 |
p.D494A | STAD | 1 |
p.P437S | BLCA | 1 |
p.E169Q | LUAD | 1 |
p.L240F | SKCM | 1 |
p.M150I | HNSC | 1 |
p.K311N | UCS | 1 |
p.N112Y | KIRP | 1 |
p.A36V | SARC | 1 |
p.D315N | SKCM | 1 |
p.A224T | STAD | 1 |
p.G426E | SKCM | 1 |
p.C384* | PAAD | 1 |
p.P393L | SKCM | 1 |
p.G426R | STAD | 1 |
p.R261C | STAD | 1 |
p.L98I | THYM | 1 |
p.T472A | CESC | 1 |
p.V283A | KICH | 1 |
p.R353L | UCEC | 1 |
p.F325L | LUAD | 1 |
p.T472A | UVM | 1 |
p.Y39* | SKCM | 1 |
p.G511R | SKCM | 1 |
p.R490H | GBM | 1 |
p.Q86K | LUAD | 1 |
p.R390W | UCEC | 1 |
p.D105Y | THYM | 1 |
p.R148H | SARC | 1 |
p.W144* | SKCM | 1 |
p.L20P | LIHC | 1 |
p.R46G | LUAD | 1 |
p.S399F | SKCM | 1 |
p.R515Q | STAD | 1 |
p.L313F | HNSC | 1 |
p.R390L | LUAD | 1 |
p.P498L | SKCM | 1 |
p.Q281* | SKCM | 1 |
p.P435L | GBM | 1 |
p.D201G | SKCM | 1 |
p.R276H | UCEC | 1 |
p.E184Q | BLCA | 1 |
p.E477K | SKCM | 1 |
p.D105N | COAD | 1 |
p.L278I | LUAD | 1 |
p.N158S | SKCM | 1 |
p.R47P | LUAD | 1 |
p.A345V | THYM | 1 |
p.T472A | PCPG | 1 |
p.P394R | BRCA | 1 |
p.R149Q | PRAD | 1 |
p.A224T | COAD | 1 |
p.L48F | SKCM | 1 |
p.S233* | BLCA | 1 |
p.P394T | UCEC | 1 |
p.A224T | PAAD | 1 |
p.R390G | LUAD | 1 |
p.E438D | PAAD | 1 |
p.R488C | KIRC | 1 |
p.A40T | STAD | 1 |
p.D265N | BLCA | 1 |
p.R488H | HNSC | 1 |
p.K165N | SKCM | 1 |
p.Q204H | ESCA | 1 |
p.R444H | STAD | 1 |
p.M164I | SKCM | 1 |
p.P431Q | LUAD | 1 |
p.R365C | MESO | 1 |
p.N168D | ESCA | 1 |
p.S114L | LUAD | 1 |
p.R57G | LUAD | 1 |
p.R515W | SARC | 1 |
p.A269D | SKCM | 1 |
p.S196I | UCEC | 1 |
p.P455H | PAAD | 1 |
p.Q281X | SKCM | 1 |
p.V340L | LUAD | 1 |
p.R49W | UCEC | 1 |
p.S96T | SKCM | 1 |
p.G470R | UCEC | 1 |
p.R444S | ESCA | 1 |
p.D284N | SKCM | 1 |
p.D284H | BLCA | 1 |
p.R274W | OV | 1 |
p.D201N | UCEC | 1 |
p.R149Q | BRCA | 1 |
p.E238Q | HNSC | 1 |
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TissGeneCNV for CYP4F2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CYP4F2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | LUSC | TCGA-22-A5C4-01A | MAGED1-CYP4F2 | CDS-5'UTR | chrX:51643392 | chr19:16003392 |
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TissGeneNet for CYP4F2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CYP4F2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CYP4F2 |
TissGeneDrug for CYP4F2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CYP4F2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 11 | BeFree,GAD,LHGDN |
umls:C0038454 | Cerebrovascular accident | 7 | BeFree,GAD,LHGDN |
umls:C0948008 | Ischemic stroke | 5 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 5 | BeFree |
umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD,LHGDN |
umls:C0007786 | Brain Ischemia | 2 | GAD |
umls:C0085580 | Essential Hypertension | 2 | BeFree |
umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 2 | BeFree |
umls:C0004238 | Atrial Fibrillation | 1 | GAD |
umls:C0007570 | Celiac Disease | 1 | BeFree |
umls:C0007785 | Cerebral Infarction | 1 | BeFree,GAD,LHGDN |
umls:C0020443 | Hypercholesterolemia | 1 | BeFree |
umls:C0042373 | Vascular Diseases | 1 | BeFree |
umls:C0042487 | Venous Thrombosis | 1 | GAD |
umls:C0232197 | Fibrillation | 1 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1861172 | Venous Thromboembolism | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |