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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ABCC11
check button Gene summary
Basic gene informationGene symbolABCC11
Gene nameATP-binding cassette, sub-family C (CFTR/MRP), member 11
SynonymsEWWD|MRP8|WW
CytomapUCSC genome browser: 16q12.1
Type of geneprotein-coding
RefGenesNM_032583.3,
NM_033151.3,NM_145186.2,
DescriptionATP-binding cassette protein C11ATP-binding cassette sub-family C member 11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11multi-resistance protein 8multidrug resistance-associated protein 8
Modification date20141207
dbXrefs MIM : 607040
HGNC : HGNC
Ensembl : ENSG00000121270
HPRD : 06127
Vega : OTTHUMG00000133146
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ABCC11
BioGPS: 85320
PathwayNCI Pathway Interaction Database: ABCC11
KEGG: ABCC11
REACTOME: ABCC11
Pathway Commons: ABCC11
ContextiHOP: ABCC11
ligand binding site mutation search in PubMed: ABCC11
UCL Cancer Institute: ABCC11
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BreastTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BRCATGCT
Reference showing the relevant tissue of ABCC11
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0015711organic anion transport15537867
GO:0015865purine nucleotide transport12764137
GO:0015711organic anion transport15537867
GO:0015865purine nucleotide transport12764137


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TissGeneExp for ABCC11

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-0.877514758-3.1121045882.2345898311.41E-097.94E-09
LUSC-2.473045067-3.5192862431.0462411761.59E-084.90E-08
LUAD-2.72597671-3.7344525721.0084758629.03E-062.66E-05


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TissGene-miRNA for ABCC11

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ABCC11
TissGeneSNV for ABCC11

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.T1154KLGG2
p.P1132SSKCM2
p.Q1133HLUAD2
p.I962TLGG1
p.S1216YESCA1
p.L899FSKCM1
p.S650FSKCM1
p.T442MSTAD1
p.G506ESKCM1
p.Q1024RESCA1
p.N897DREAD1
p.S662FLUAD1
p.L316RSTAD1
p.R1294CBLCA1
p.F263LBLCA1
p.L346IUCEC1
p.F432LUCEC1
p.G1016ESKCM1
p.R841QSTAD1
p.R1335HLGG1
p.V97MUCEC1
p.A399VUCEC1
p.S892FHNSC1
p.F476LSKCM1
p.Q743KLUAD1
p.E560KSKCM1
p.C1327FUCEC1
p.L1158FSKCM1
p.E344*LUAD1
p.H134YSTAD1
p.S121XACC1
p.A513VBLCA1
p.A1375TLGG1
p.I1288FUCEC1
p.R19HCOAD1
p.E244DUCEC1
p.R75HESCA1
p.Q1032HUCEC1
p.P435SESCA1
p.C543FLUAD1
p.A1047VLGG1
p.G724WPRAD1
p.T893MBLCA1
p.S567LSKCM1
p.L899ITHYM1
p.A950TBLCA1
p.L574MUCEC1
p.R111CSKCM1
p.H1306RCOAD1
p.D65NLUAD1
p.F1025LSARC1
p.V1353_spliceLUSC1
p.D926NHNSC1
p.A317ECOAD1
p.S717NHNSC1
p.G1203SLUAD1
p.S1011YESCA1
p.H405YSKCM1
p.H134YCESC1
p.G628*BLCA1
p.E358DUCEC1
p.R233WKIRC1
p.S1075FSKCM1
p.R1049SKIRC1
p.G877ESKCM1
p.R428WHNSC1
p.V345ICOAD1
p.V325MSTAD1
p.R1294HUCEC1
p.Q248HREAD1
p.V577ASTAD1
p.E565QLIHC1
p.T1129ILUAD1
p.P78LPRAD1
p.M155TLIHC1
p.L1028PCOAD1
p.G966ABLCA1
p.S1075FHNSC1
p.R646CLUSC1
p.T1314NTHYM1
p.A597TESCA1
p.S121*ACC1
p.P50ABLCA1
p.I730TLUAD1
p.P118SSKCM1
p.R1215WPAAD1
p.A286TUCEC1
p.F462IBRCA1
p.F824LCESC1
p.L205ILUAD1
p.R630WDLBC1
p.A286TSTAD1
p.V1084MESCA1
p.E114VLUAD1
p.L385VBLCA1
p.T1177MUCEC1
p.G628EBLCA1
p.G145RLUAD1
p.M1148LHNSC1
p.R135HUCEC1
p.G851DCOAD1
p.R1049MKIRC1
p.V1108LLUAD1
p.S471IUCEC1
p.L705FHNSC1
p.G493ELUAD1
p.R995WCOAD1
p.P915QLUAD1
p.W43*LUSC1
p.R1096WPRAD1
p.E358KSKCM1
p.E273QLUSC1
p.L152FLGG1
p.P773LKIRP1
p.A414VPAAD1
p.A597TUCEC1
p.L1293PLUAD1
p.D22NUCEC1
p.I349TKIRP1
p.T1305SLUAD1
p.A1306SSTAD1
p.R1096QBLCA1
p.Y463NSKCM1
p.M1115ILUAD1
p.T442MGBM1
p.D26YSTAD1
p.R841*STAD1
p.M155IUCEC1
p.L163FPRAD1
p.L412FUCEC1
p.S650YLUAD1
p.W99*SKCM1
p.R1294CSKCM1
p.Q84KESCA1
p.S551IUCEC1
p.R229CLGG1
p.T1231ISKCM1
p.E259VLUAD1
p.R1176KOV1
p.E213KUCEC1
p.H528QLUAD1
p.P660LACC1
p.P118HSTAD1
p.A167SLUAD1
p.L209PSTAD1
p.D659NREAD1
p.A950TPAAD1
p.E344DLUAD1
p.A1371TSTAD1
p.V542FLUAD1
p.D1302NSKCM1
p.E782*OV1
p.P279LSKCM1
p.S881*LUAD1
p.E629KSKCM1
p.C906GLUAD1
p.D1264NSKCM1
p.Q653HHNSC1
p.R841PBLCA1
p.A1066TTHYM1
p.V805ISKCM1
p.Y277CLUAD1
p.A1088ECESC1
p.A924TREAD1
p.S643NUCEC1
p.V58IESCA1
p.R109QTHYM1
p.R841XSTAD1
p.R1335PACC1
p.P960LSKCM1
p.E785*UCEC1
p.A1031VPRAD1
p.E1100ABLCA1
p.T406AUCEC1
p.G380RSTAD1
p.V687ISTAD1
p.S1070FSKCM1
p.R1290KLUSC1
p.A647TLUAD1
p.L850PUCEC1
p.R1215WACC1
p.R646HSTAD1
p.Q1223EBRCA1
p.G1230ESKCM1
p.R144*UCEC1
p.H254RLUAD1
p.R338CCESC1
p.I1320NLUAD1
p.V28FUCEC1
p.V334DLUAD1
p.R841*UCEC1
p.I253KBLCA1
p.P1222SSKCM1
p.Y993HSKCM1
p.A581VLUSC1
p.S717NLIHC1


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TissGeneCNV for ABCC11

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ABCC11

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanBRCATCGA-BH-A0C3-01ASKAP1-ABCC11In-Framechr17:46423266chr16:48209328
TCGAfusionPortalPRADABRCATCGA-BH-A0C3-01ASKAP1-ABCC11Out-of-frameChr17:46423267Chr16:48211024
TCGAfusionPortalPRADABRCATCGA-C8-A138-01AANO1-ABCC11Out-of-frameChr11:69972301Chr16:48211024
TCGAfusionPortalPRADALUADTCGA-91-6847-01ADDX19A-ABCC11CDS-5UTRChr16:70384508Chr16:48269088


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TissGeneNet for ABCC11

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for ABCC11

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ABCC11
TissGeneDrug for ABCC11

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ABCC11

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast9BeFree,GAD
umls:C0678222Breast Carcinoma9BeFree
umls:C0023487Acute Promyelocytic Leukemia4BeFree
umls:C0263472Bromhidrosis4BeFree
umls:C0036690Septicemia3BeFree
umls:C0243026Sepsis3BeFree
umls:C0010674Cystic Fibrosis2BeFree
umls:C0023418leukemia2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0042384Vasculitis2BeFree,LHGDN
umls:C0596263Carcinogenesis2BeFree
umls:C1141926Abdominal sepsis2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0007104Female Breast Carcinoma1BeFree
umls:C0010034Corneal Diseases1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0022568Keratitis1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023530Leukopenia1BeFree
umls:C0024301Lymphoma, Follicular1BeFree
umls:C0026691Mucocutaneous Lymph Node Syndrome1BeFree
umls:C0027121Myositis1BeFree
umls:C0028754Obesity1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0030354Papilloma1BeFree
umls:C0031154Peritonitis1BeFree
umls:C0038986Sweat Gland Diseases1GAD
umls:C0042842Vitamin A Deficiency1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0151514Atrophic condition of skin1BeFree
umls:C0178664Glomerulosclerosis (disorder)1BeFree
umls:C0235653Malignant neoplasm of female breast1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0242656Disease Progression1CTD_human
umls:C0263666Dermatomyositis, Childhood Type1BeFree
umls:C0333186Restenosis1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0519030Pneumonia due to Klebsiella pneumoniae1BeFree
umls:C0520679Sleep Apnea, Obstructive1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0854135Pseudomonas aeruginosa infection1BeFree
umls:C0854211Bacterial keratitis1BeFree
umls:C0947751Vascular inflammations1BeFree
umls:C0949691Spondylarthropathies1BeFree
umls:C1719672Severe Sepsis1BeFree
umls:C2004493Leukemia, B-Cell1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C2931785Juvenile dermatomyositis1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C1861696EAR WAX, WET/DRY0CLINVAR