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| TissGeneSummary for ABCC11 |
 Gene summary |
| Basic gene information | Gene symbol | ABCC11 |
| Gene name | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 | |
| Synonyms | EWWD|MRP8|WW | |
| Cytomap | UCSC genome browser: 16q12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032583.3, NM_033151.3,NM_145186.2, | |
| Description | ATP-binding cassette protein C11ATP-binding cassette sub-family C member 11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11multi-resistance protein 8multidrug resistance-associated protein 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607040 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121270 | ||
| HPRD : 06127 | ||
| Vega : OTTHUMG00000133146 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ABCC11 | |
| BioGPS: 85320 | ||
| Pathway | NCI Pathway Interaction Database: ABCC11 | |
| KEGG: ABCC11 | ||
| REACTOME: ABCC11 | ||
| Pathway Commons: ABCC11 | ||
| Context | iHOP: ABCC11 | |
| ligand binding site mutation search in PubMed: ABCC11 | ||
| UCL Cancer Institute: ABCC11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCATGCT | |
| Reference showing the relevant tissue of ABCC11 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0015711 | organic anion transport | 15537867 | GO:0015865 | purine nucleotide transport | 12764137 | GO:0015711 | organic anion transport | 15537867 | GO:0015865 | purine nucleotide transport | 12764137 |
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| TissGeneExp for ABCC11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -0.877514758 | -3.112104588 | 2.234589831 | 1.41E-09 | 7.94E-09 |
| LUSC | -2.473045067 | -3.519286243 | 1.046241176 | 1.59E-08 | 4.90E-08 |
| LUAD | -2.72597671 | -3.734452572 | 1.008475862 | 9.03E-06 | 2.66E-05 |
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| TissGene-miRNA for ABCC11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ABCC11 |
| TissGeneSNV for ABCC11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T1154K | LGG | 2 |
| p.P1132S | SKCM | 2 |
| p.Q1133H | LUAD | 2 |
| p.I962T | LGG | 1 |
| p.S1216Y | ESCA | 1 |
| p.L899F | SKCM | 1 |
| p.S650F | SKCM | 1 |
| p.T442M | STAD | 1 |
| p.G506E | SKCM | 1 |
| p.Q1024R | ESCA | 1 |
| p.N897D | READ | 1 |
| p.S662F | LUAD | 1 |
| p.L316R | STAD | 1 |
| p.R1294C | BLCA | 1 |
| p.F263L | BLCA | 1 |
| p.L346I | UCEC | 1 |
| p.F432L | UCEC | 1 |
| p.G1016E | SKCM | 1 |
| p.R841Q | STAD | 1 |
| p.R1335H | LGG | 1 |
| p.V97M | UCEC | 1 |
| p.A399V | UCEC | 1 |
| p.S892F | HNSC | 1 |
| p.F476L | SKCM | 1 |
| p.Q743K | LUAD | 1 |
| p.E560K | SKCM | 1 |
| p.C1327F | UCEC | 1 |
| p.L1158F | SKCM | 1 |
| p.E344* | LUAD | 1 |
| p.H134Y | STAD | 1 |
| p.S121X | ACC | 1 |
| p.A513V | BLCA | 1 |
| p.A1375T | LGG | 1 |
| p.I1288F | UCEC | 1 |
| p.R19H | COAD | 1 |
| p.E244D | UCEC | 1 |
| p.R75H | ESCA | 1 |
| p.Q1032H | UCEC | 1 |
| p.P435S | ESCA | 1 |
| p.C543F | LUAD | 1 |
| p.A1047V | LGG | 1 |
| p.G724W | PRAD | 1 |
| p.T893M | BLCA | 1 |
| p.S567L | SKCM | 1 |
| p.L899I | THYM | 1 |
| p.A950T | BLCA | 1 |
| p.L574M | UCEC | 1 |
| p.R111C | SKCM | 1 |
| p.H1306R | COAD | 1 |
| p.D65N | LUAD | 1 |
| p.F1025L | SARC | 1 |
| p.V1353_splice | LUSC | 1 |
| p.D926N | HNSC | 1 |
| p.A317E | COAD | 1 |
| p.S717N | HNSC | 1 |
| p.G1203S | LUAD | 1 |
| p.S1011Y | ESCA | 1 |
| p.H405Y | SKCM | 1 |
| p.H134Y | CESC | 1 |
| p.G628* | BLCA | 1 |
| p.E358D | UCEC | 1 |
| p.R233W | KIRC | 1 |
| p.S1075F | SKCM | 1 |
| p.R1049S | KIRC | 1 |
| p.G877E | SKCM | 1 |
| p.R428W | HNSC | 1 |
| p.V345I | COAD | 1 |
| p.V325M | STAD | 1 |
| p.R1294H | UCEC | 1 |
| p.Q248H | READ | 1 |
| p.V577A | STAD | 1 |
| p.E565Q | LIHC | 1 |
| p.T1129I | LUAD | 1 |
| p.P78L | PRAD | 1 |
| p.M155T | LIHC | 1 |
| p.L1028P | COAD | 1 |
| p.G966A | BLCA | 1 |
| p.S1075F | HNSC | 1 |
| p.R646C | LUSC | 1 |
| p.T1314N | THYM | 1 |
| p.A597T | ESCA | 1 |
| p.S121* | ACC | 1 |
| p.P50A | BLCA | 1 |
| p.I730T | LUAD | 1 |
| p.P118S | SKCM | 1 |
| p.R1215W | PAAD | 1 |
| p.A286T | UCEC | 1 |
| p.F462I | BRCA | 1 |
| p.F824L | CESC | 1 |
| p.L205I | LUAD | 1 |
| p.R630W | DLBC | 1 |
| p.A286T | STAD | 1 |
| p.V1084M | ESCA | 1 |
| p.E114V | LUAD | 1 |
| p.L385V | BLCA | 1 |
| p.T1177M | UCEC | 1 |
| p.G628E | BLCA | 1 |
| p.G145R | LUAD | 1 |
| p.M1148L | HNSC | 1 |
| p.R135H | UCEC | 1 |
| p.G851D | COAD | 1 |
| p.R1049M | KIRC | 1 |
| p.V1108L | LUAD | 1 |
| p.S471I | UCEC | 1 |
| p.L705F | HNSC | 1 |
| p.G493E | LUAD | 1 |
| p.R995W | COAD | 1 |
| p.P915Q | LUAD | 1 |
| p.W43* | LUSC | 1 |
| p.R1096W | PRAD | 1 |
| p.E358K | SKCM | 1 |
| p.E273Q | LUSC | 1 |
| p.L152F | LGG | 1 |
| p.P773L | KIRP | 1 |
| p.A414V | PAAD | 1 |
| p.A597T | UCEC | 1 |
| p.L1293P | LUAD | 1 |
| p.D22N | UCEC | 1 |
| p.I349T | KIRP | 1 |
| p.T1305S | LUAD | 1 |
| p.A1306S | STAD | 1 |
| p.R1096Q | BLCA | 1 |
| p.Y463N | SKCM | 1 |
| p.M1115I | LUAD | 1 |
| p.T442M | GBM | 1 |
| p.D26Y | STAD | 1 |
| p.R841* | STAD | 1 |
| p.M155I | UCEC | 1 |
| p.L163F | PRAD | 1 |
| p.L412F | UCEC | 1 |
| p.S650Y | LUAD | 1 |
| p.W99* | SKCM | 1 |
| p.R1294C | SKCM | 1 |
| p.Q84K | ESCA | 1 |
| p.S551I | UCEC | 1 |
| p.R229C | LGG | 1 |
| p.T1231I | SKCM | 1 |
| p.E259V | LUAD | 1 |
| p.R1176K | OV | 1 |
| p.E213K | UCEC | 1 |
| p.H528Q | LUAD | 1 |
| p.P660L | ACC | 1 |
| p.P118H | STAD | 1 |
| p.A167S | LUAD | 1 |
| p.L209P | STAD | 1 |
| p.D659N | READ | 1 |
| p.A950T | PAAD | 1 |
| p.E344D | LUAD | 1 |
| p.A1371T | STAD | 1 |
| p.V542F | LUAD | 1 |
| p.D1302N | SKCM | 1 |
| p.E782* | OV | 1 |
| p.P279L | SKCM | 1 |
| p.S881* | LUAD | 1 |
| p.E629K | SKCM | 1 |
| p.C906G | LUAD | 1 |
| p.D1264N | SKCM | 1 |
| p.Q653H | HNSC | 1 |
| p.R841P | BLCA | 1 |
| p.A1066T | THYM | 1 |
| p.V805I | SKCM | 1 |
| p.Y277C | LUAD | 1 |
| p.A1088E | CESC | 1 |
| p.A924T | READ | 1 |
| p.S643N | UCEC | 1 |
| p.V58I | ESCA | 1 |
| p.R109Q | THYM | 1 |
| p.R841X | STAD | 1 |
| p.R1335P | ACC | 1 |
| p.P960L | SKCM | 1 |
| p.E785* | UCEC | 1 |
| p.A1031V | PRAD | 1 |
| p.E1100A | BLCA | 1 |
| p.T406A | UCEC | 1 |
| p.G380R | STAD | 1 |
| p.V687I | STAD | 1 |
| p.S1070F | SKCM | 1 |
| p.R1290K | LUSC | 1 |
| p.A647T | LUAD | 1 |
| p.L850P | UCEC | 1 |
| p.R1215W | ACC | 1 |
| p.R646H | STAD | 1 |
| p.Q1223E | BRCA | 1 |
| p.G1230E | SKCM | 1 |
| p.R144* | UCEC | 1 |
| p.H254R | LUAD | 1 |
| p.R338C | CESC | 1 |
| p.I1320N | LUAD | 1 |
| p.V28F | UCEC | 1 |
| p.V334D | LUAD | 1 |
| p.R841* | UCEC | 1 |
| p.I253K | BLCA | 1 |
| p.P1222S | SKCM | 1 |
| p.Y993H | SKCM | 1 |
| p.A581V | LUSC | 1 |
| p.S717N | LIHC | 1 |
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| TissGeneCNV for ABCC11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ABCC11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0C3-01A | SKAP1-ABCC11 | In-Frame | chr17:46423266 | chr16:48209328 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0C3-01A | SKAP1-ABCC11 | Out-of-frame | Chr17:46423267 | Chr16:48211024 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A138-01A | ANO1-ABCC11 | Out-of-frame | Chr11:69972301 | Chr16:48211024 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-91-6847-01A | DDX19A-ABCC11 | CDS-5UTR | Chr16:70384508 | Chr16:48269088 |
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| TissGeneNet for ABCC11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ABCC11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ABCC11 |
| TissGeneDrug for ABCC11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ABCC11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 9 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 9 | BeFree |
| umls:C0023487 | Acute Promyelocytic Leukemia | 4 | BeFree |
| umls:C0263472 | Bromhidrosis | 4 | BeFree |
| umls:C0036690 | Septicemia | 3 | BeFree |
| umls:C0243026 | Sepsis | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 2 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0042384 | Vasculitis | 2 | BeFree,LHGDN |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1141926 | Abdominal sepsis | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0007104 | Female Breast Carcinoma | 1 | BeFree |
| umls:C0010034 | Corneal Diseases | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0022568 | Keratitis | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0024301 | Lymphoma, Follicular | 1 | BeFree |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 1 | BeFree |
| umls:C0027121 | Myositis | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0030354 | Papilloma | 1 | BeFree |
| umls:C0031154 | Peritonitis | 1 | BeFree |
| umls:C0038986 | Sweat Gland Diseases | 1 | GAD |
| umls:C0042842 | Vitamin A Deficiency | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0151514 | Atrophic condition of skin | 1 | BeFree |
| umls:C0178664 | Glomerulosclerosis (disorder) | 1 | BeFree |
| umls:C0235653 | Malignant neoplasm of female breast | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242656 | Disease Progression | 1 | CTD_human |
| umls:C0263666 | Dermatomyositis, Childhood Type | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0519030 | Pneumonia due to Klebsiella pneumoniae | 1 | BeFree |
| umls:C0520679 | Sleep Apnea, Obstructive | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0854135 | Pseudomonas aeruginosa infection | 1 | BeFree |
| umls:C0854211 | Bacterial keratitis | 1 | BeFree |
| umls:C0947751 | Vascular inflammations | 1 | BeFree |
| umls:C0949691 | Spondylarthropathies | 1 | BeFree |
| umls:C1719672 | Severe Sepsis | 1 | BeFree |
| umls:C2004493 | Leukemia, B-Cell | 1 | BeFree |
| umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
| umls:C2931785 | Juvenile dermatomyositis | 1 | BeFree |
| umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
| umls:C1861696 | EAR WAX, WET/DRY | 0 | CLINVAR |
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