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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC45A3
check button Gene summary
Basic gene informationGene symbolSLC45A3
Gene namesolute carrier family 45, member 3
SynonymsIPCA-2|IPCA-6|IPCA-8|IPCA6|PCANAP2|PCANAP6|PCANAP8|PRST
CytomapUCSC genome browser: 1q32.1
Type of geneprotein-coding
RefGenesNM_033102.2,
Descriptionprostate cancer associated protein 2prostate cancer associated protein 6prostate cancer associated protein 8prostate cancer-associated gene 2prostate cancer-associated gene 6prostate cancer-associated gene 8prostate cancer-associated protein 6prost
Modification date20141212
dbXrefs MIM : 605097
HGNC : HGNC
Ensembl : ENSG00000158715
HPRD : 16312
Vega : OTTHUMG00000037223
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC45A3
BioGPS: 85414
PathwayNCI Pathway Interaction Database: SLC45A3
KEGG: SLC45A3
REACTOME: SLC45A3
Pathway Commons: SLC45A3
ContextiHOP: SLC45A3
ligand binding site mutation search in PubMed: SLC45A3
UCL Cancer Institute: SLC45A3
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of SLC45A3SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Rickman DS, Pflueger D, Moss B, VanDoren VE, Chen CX, de la Taille A, Kuefer R, Tewari AK, Setlur SR, Demichelis F, Rubin MA. Cancer Res. 2009 Apr 1;69(7):2734-8. doi: 10.1158/0008-5472.CAN-08-4926. Epub 2009 Mar 17 (pmid:19293179)
go to article
Description by TissGene annotationsProtective TissGene in RFS
Cancer gene
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SLC45A3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-3.1437234740.281340526-3.4250641.39E-153.16E-14
LIHC-0.2389234741.166920526-1.4058441.82E-102.31E-09
PRAD7.5454779875.8139049111.7315730770.0003770.001373751


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TissGene-miRNA for SLC45A3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SLC45A3
TissGeneSNV for SLC45A3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R272GOV1
p.G103CLUSC1
p.V470IDLBC1
p.A34TLGG1
p.T311ISKCM1
p.A333TCOAD1
p.E121QLUSC1
p.R158HSTAD1
p.P484SSKCM1
p.E220KSKCM1
p.P117TESCA1
p.G83SLIHC1
p.V542ICESC1
p.G462RSTAD1
p.A255TCOAD1
p.R79CSTAD1
p.D153NBLCA1
p.R245WSKCM1
p.R247CGBM1
p.G462VLUAD1
p.S546TBRCA1
p.H156YSKCM1
p.Y536XESCA1
p.R85HUCS1
p.E50KSKCM1
p.Q3HSTAD1
p.G47WLUAD1
p.R269HBLCA1
p.T287ASTAD1
p.P309LOV1
p.S73LCESC1
p.G462WLUAD1
p.L453MLIHC1
p.T293MTHYM1
p.R272HPRAD1
p.F200VCOAD1
p.L102FSKCM1
p.D491YBLCA1
p.A255VUCEC1
p.R84CGBM1
p.Y56HUCEC1
p.V276MKIRC1
p.M53IBLCA1
p.A459VLGG1
p.V129LBRCA1
p.T311ASTAD1
p.L177IESCA1
p.Q503HUCEC1
p.P87LSKCM1
p.G434DPAAD1
p.S256LGBM1
p.L24QLUAD1


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TissGeneCNV for SLC45A3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC45A3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAS81007SLC45A3-MLLT1chr1:205616219chr19:6277149
Chimerdb3.0ChiTaRsNABF854872PRKCA-SLC45A3chr17:64571947chr1:205633006
Chimerdb3.0ChiTaRsadenocarcinomaEU314932SLC45A3-ETV5chr1:205649751chr3:185775008
Chimerdb3.0ChiTaRsadenocarcinomaEF632109SLC45A3-ETV1chr1:205649747chr7:13978820
Chimerdb3.0ChiTaRsadenocarcinomaGU149303SLC45A3-BRAFchr1:205649630chr7:140433812
Chimerdb3.0FusionScanPRADTCGA-G9-6336-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13975521
Chimerdb3.0FusionScanPRADTCGA-2A-A8W3-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978871
Chimerdb3.0FusionScanPRADTCGA-XJ-A9DQ-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-HC-7821-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-HC-A6AQ-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978871
Chimerdb3.0FusionScanPRADTCGA-M7-A71Y-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978871
Chimerdb3.0FusionScanPRADTCGA-KK-A7AP-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978871
Chimerdb3.0FusionScanPRADTCGA-YL-A9WX-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-KK-A8I5-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-HC-A6AN-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-HC-7820-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-HC-A8CY-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978871
Chimerdb3.0FusionScanPRADTCGA-G9-7522-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanPRADTCGA-G9-6351-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817544
Chimerdb3.0FusionScanLUSCTCGA-22-5492-01ASLC45A3-ELK45'UTR-5'UTRchr1:205649521chr1:205593019
Chimerdb3.0FusionScanPRADTCGA-FC-A5OB-01ASLC45A3-ZBTB7B5'UTR-5'UTRchr1:205649521chr1:154987130
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6351-01ASLC45A3-ERG5'UTR-5'UTRchr1:205648939chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6351-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-J4-A83M-01ASLC45A3-ETV15'UTR-CDSchr1:205648939chr7:14017104
Chimerdb3.0TopHat-FusionPRADTCGA-J4-A83M-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:14017104
Chimerdb3.0TopHat-FusionPRADTCGA-KK-A7AP-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978870
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7820-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-KK-A8I5-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-M7-A71Y-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978870
Chimerdb3.0TopHat-FusionPRADTCGA-J4-A83N-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7821-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-HC-A8CY-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978870
Chimerdb3.0TopHat-FusionPRADTCGA-G9-7522-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-HC-A6AN-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7748-01ASLC45A3-ERG5'UTR-5'UTRchr1:205649521chr21:39817543
Chimerdb3.0TopHat-FusionPRADTCGA-2A-A8W3-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978870
Chimerdb3.0TopHat-FusionPRADTCGA-HC-A6AQ-01ASLC45A3-ETV15'UTR-CDSchr1:205649521chr7:13978870
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6499-11AMEF2D-SLC45A3CDS-5'UTRchr1:156448999chr1:205649521
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6499-11AMEF2D-SLC45A3CDS-5'UTRchr1:156450877chr1:205649521
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6499-11AMEF2D-SLC45A35'UTR-5'UTRchr1:156453535chr1:205649521
Chimerdb3.0TopHat-FusionPRADTCGA-FC-A5OB-01ASLC45A3-ZBTB7B5'UTR-5'UTRchr1:205649521chr1:154986490
Chimerdb3.0TopHat-FusionPRADTCGA-FC-A5OB-01ASLC45A3-ZBTB7B5'UTR-5'UTRchr1:205649521chr1:154987130
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7211-01ASLC45A3-EPB41L4BOut-of-Framechr1:205628616chr9:112042200
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7211-01ASLC45A3-EPB41L4BIn-Framechr1:205630988chr9:112042200


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TissGeneNet for SLC45A3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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COAD (tumor)COAD (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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HNSC (tumor)HNSC (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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KICH (tumor)KICH (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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KIRC (tumor)KIRC (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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KIRP (tumor)KIRP (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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LIHC (tumor)LIHC (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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LUAD (tumor)LUAD (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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LUSC (tumor)LUSC (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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PRAD (tumor)PRAD (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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STAD (tumor)STAD (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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THCA (tumor)THCA (normal)
SLC45A3, AR (tumor)SLC45A3, AR (normal)
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TissGeneProg for SLC45A3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC45A3
TissGeneDrug for SLC45A3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC45A3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate7BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0033578Prostatic Neoplasms4BeFree,LHGDN
umls:C0004096Asthma1GAD
umls:C0030567Parkinson Disease1GAD