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| TissGeneSummary for CCNB3 |
 Gene summary |
| Basic gene information | Gene symbol | CCNB3 |
| Gene name | cyclin B3 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: Xp11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_033031.2, NM_033670.2,NM_033671.1, | |
| Description | G2/mitotic-specific cyclin-B3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300456 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147082 | ||
| HPRD : 02350 | ||
| Vega : OTTHUMG00000021519 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCNB3 | |
| BioGPS: 85417 | ||
| Pathway | NCI Pathway Interaction Database: CCNB3 | |
| KEGG: CCNB3 | ||
| REACTOME: CCNB3 | ||
| Pathway Commons: CCNB3 | ||
| Context | iHOP: CCNB3 | |
| ligand binding site mutation search in PubMed: CCNB3 | ||
| UCL Cancer Institute: CCNB3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Soft tissueTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SARCTGCT | |
| Reference showing the relevant tissue of CCNB3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CCNB3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.301749344 | 0.858782656 | -1.160532 | 3.70E-05 | 0.000104817 |
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| TissGene-miRNA for CCNB3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CCNB3 |
| TissGeneSNV for CCNB3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P1322S | SKCM | 2 |
| p.E422* | UCEC | 2 |
| p.P218S | SKCM | 2 |
| p.S585* | LUAD | 1 |
| p.E590K | SKCM | 1 |
| p.K226N | UCEC | 1 |
| p.S717I | GBM | 1 |
| p.A981T | HNSC | 1 |
| p.S809N | SKCM | 1 |
| p.Q637H | LUAD | 1 |
| p.S688Y | LUSC | 1 |
| p.M415L | LUAD | 1 |
| p.S412L | UCEC | 1 |
| p.H826Q | UCEC | 1 |
| p.F690L | SKCM | 1 |
| p.E795G | THCA | 1 |
| p.H855D | HNSC | 1 |
| p.K1216Q | LGG | 1 |
| p.K179Q | STAD | 1 |
| p.M1150I | LUAD | 1 |
| p.M140I | SKCM | 1 |
| p.R1224C | SKCM | 1 |
| p.D203Y | UCEC | 1 |
| p.N742H | UCEC | 1 |
| p.G1105E | SKCM | 1 |
| p.E169K | GBM | 1 |
| p.H682R | HNSC | 1 |
| p.S518L | SKCM | 1 |
| p.K685Q | HNSC | 1 |
| p.S878P | COAD | 1 |
| p.E715K | LUAD | 1 |
| p.M263I | LUAD | 1 |
| p.A270V | SKCM | 1 |
| p.D1352N | SKCM | 1 |
| p.R397H | UCEC | 1 |
| p.N779K | SKCM | 1 |
| p.E209* | UCEC | 1 |
| p.K233N | OV | 1 |
| p.S944F | SKCM | 1 |
| p.S585L | SKCM | 1 |
| p.E1325K | SKCM | 1 |
| p.K301N | ACC | 1 |
| p.E1368D | BRCA | 1 |
| p.S544F | UCEC | 1 |
| p.H1363Y | SKCM | 1 |
| p.R1270M | LUAD | 1 |
| p.R1113W | THYM | 1 |
| p.S361F | OV | 1 |
| p.D1190N | UCEC | 1 |
| p.N106K | LIHC | 1 |
| p.Q353R | LUAD | 1 |
| p.E246* | UCEC | 1 |
| p.K1299E | OV | 1 |
| p.T1111I | SARC | 1 |
| p.P302R | HNSC | 1 |
| p.H495Y | ESCA | 1 |
| p.D283H | SKCM | 1 |
| p.Y1358H | LUSC | 1 |
| p.D1387H | SKCM | 1 |
| p.R397P | LUSC | 1 |
| p.T500A | UCEC | 1 |
| p.K317N | THYM | 1 |
| p.K708* | UCEC | 1 |
| p.E48K | SKCM | 1 |
| p.S314F | SKCM | 1 |
| p.L283V | STAD | 1 |
| p.E185D | LUAD | 1 |
| p.Q18E | CESC | 1 |
| p.P955L | SKCM | 1 |
| p.R108Q | UCEC | 1 |
| p.F206L | HNSC | 1 |
| p.S200I | KIRC | 1 |
| p.A1032T | STAD | 1 |
| p.K174Q | COAD | 1 |
| p.R1224C | BLCA | 1 |
| p.K317N | UCEC | 1 |
| p.E770X | THYM | 1 |
| p.D248N | SKCM | 1 |
| p.T1178P | LGG | 1 |
| p.F327S | STAD | 1 |
| p.G409E | SKCM | 1 |
| p.H1179Y | STAD | 1 |
| p.P1057T | KIRC | 1 |
| p.M1377I | BLCA | 1 |
| p.T920N | BRCA | 1 |
| p.P1101T | STAD | 1 |
| p.G972E | COAD | 1 |
| p.E541D | HNSC | 1 |
| p.F856Y | SKCM | 1 |
| p.S1124R | LGG | 1 |
| p.K591M | HNSC | 1 |
| p.K1131T | STAD | 1 |
| p.A950V | SKCM | 1 |
| p.H1179Y | CHOL | 1 |
| p.R134Q | SKCM | 1 |
| p.S755Y | UCEC | 1 |
| p.S748F | LUSC | 1 |
| p.E840D | UCEC | 1 |
| p.M1244I | SKCM | 1 |
| p.R120C | SKCM | 1 |
| p.E558K | BLCA | 1 |
| p.L768F | UCS | 1 |
| p.T274S | STAD | 1 |
| p.R876G | LUAD | 1 |
| p.M598I | LUAD | 1 |
| p.K58R | BLCA | 1 |
| p.P279S | SKCM | 1 |
| p.P837S | UCEC | 1 |
| p.A1311T | UCEC | 1 |
| p.S1301Y | LUAD | 1 |
| p.D559Y | UCEC | 1 |
| p.S677L | SKCM | 1 |
| p.E1010K | BLCA | 1 |
| p.E1132K | SKCM | 1 |
| p.S90Y | LUSC | 1 |
| p.H877P | LUAD | 1 |
| p.T148S | LUSC | 1 |
| p.I490L | STAD | 1 |
| p.E928K | SKCM | 1 |
| p.E258K | SKCM | 1 |
| p.M626I | SKCM | 1 |
| p.L1375F | LUAD | 1 |
| p.T1055N | LUAD | 1 |
| p.K1355M | LUAD | 1 |
| p.T1278A | STAD | 1 |
| p.P119H | COAD | 1 |
| p.R108Q | OV | 1 |
| p.Y1319* | LUSC | 1 |
| p.M1314T | STAD | 1 |
| p.S974N | CESC | 1 |
| p.M626I | UCEC | 1 |
| p.W881L | KIRC | 1 |
| p.E935G | SKCM | 1 |
| p.F874V | LUAD | 1 |
| p.E847K | UCEC | 1 |
| p.S349L | SKCM | 1 |
| p.E163K | SKCM | 1 |
| p.I172T | COAD | 1 |
| p.M263L | LUAD | 1 |
| p.M565T | HNSC | 1 |
| p.E1245* | UCEC | 1 |
| p.E577K | HNSC | 1 |
| p.E1287X | ESCA | 1 |
| p.V1165L | STAD | 1 |
| p.S249N | COAD | 1 |
| p.E738K | BLCA | 1 |
| p.S706Y | COAD | 1 |
| p.E1069* | UCEC | 1 |
| p.S419F | SKCM | 1 |
| p.I1285V | LIHC | 1 |
| p.L713S | STAD | 1 |
| p.L398V | CESC | 1 |
| p.E853K | SKCM | 1 |
| p.Q76E | BRCA | 1 |
| p.F1048L | CESC | 1 |
| p.T497I | STAD | 1 |
| p.S585L | BRCA | 1 |
| p.H98N | READ | 1 |
| p.E638* | LUAD | 1 |
| p.E405D | READ | 1 |
| p.E116K | BRCA | 1 |
| p.E342D | UCEC | 1 |
| p.S260F | SKCM | 1 |
| p.E657* | UCEC | 1 |
| p.Q328* | SKCM | 1 |
| p.H259Y | SKCM | 1 |
| p.S1120I | LUSC | 1 |
| p.D1117N | SARC | 1 |
| p.K609N | LUAD | 1 |
| p.A932T | LUAD | 1 |
| p.A1374V | SKCM | 1 |
| p.K83T | UCEC | 1 |
| p.L1184F | LUAD | 1 |
| p.P848R | LUAD | 1 |
| p.L504F | CESC | 1 |
| p.R1266H | BLCA | 1 |
| p.V925A | COAD | 1 |
| p.N684K | CHOL | 1 |
| p.E275K | BLCA | 1 |
| p.E1035D | UCEC | 1 |
| p.E842K | SKCM | 1 |
| p.E818Q | READ | 1 |
| p.P1098L | SKCM | 1 |
| p.F369I | STAD | 1 |
| p.P523S | UCEC | 1 |
| p.S152F | SKCM | 1 |
| p.E721* | UCEC | 1 |
| p.Q691R | SKCM | 1 |
| p.Q746L | LUAD | 1 |
| p.E1109K | SKCM | 1 |
| p.S349* | UCEC | 1 |
| p.T1178I | DLBC | 1 |
| p.C181S | LUAD | 1 |
| p.Q1204H | UCEC | 1 |
| p.S849N | LUAD | 1 |
| p.P12H | UCEC | 1 |
| p.E84D | LIHC | 1 |
| p.A1162V | SKCM | 1 |
| p.K232N | UCEC | 1 |
| p.S717R | LUAD | 1 |
| p.L1049F | LUSC | 1 |
| p.A792V | COAD | 1 |
| p.L333* | UCEC | 1 |
| p.T538I | UCEC | 1 |
| p.P955L | TGCT | 1 |
| p.F1134L | BLCA | 1 |
| p.S1350Y | LUSC | 1 |
| p.P937L | LUAD | 1 |
| p.S867C | LIHC | 1 |
| p.P789L | SKCM | 1 |
| p.L1252H | LUSC | 1 |
| p.V1169M | UCEC | 1 |
| p.S349P | UCEC | 1 |
| p.L1008I | LUAD | 1 |
| p.R1224S | LUAD | 1 |
| p.L816F | SKCM | 1 |
| p.R1238Q | SKCM | 1 |
| p.A814S | LUAD | 1 |
| p.M918I | STAD | 1 |
| p.Y1327* | LUAD | 1 |
| p.A205V | STAD | 1 |
| p.M1137T | STAD | 1 |
| p.P29L | HNSC | 1 |
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| TissGeneCNV for CCNB3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CCNB3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | bone sarcoma | JN813375 | BCOR-CCNB3 | chrX:39937182 | chrX:50051504 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A3Y0-01A | PPP4R1-CCNB3 | Out-of-frame | Chr18:9614476 | ChrX:50051505 |
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| TissGeneNet for CCNB3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| COAD (tumor) | COAD (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| KICH (tumor) | KICH (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| STAD (tumor) | STAD (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| THCA (tumor) | THCA (normal) |
| CCNB3, CDK2 (tumor) | CCNB3, CDK2 (normal) |
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| TissGeneProg for CCNB3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CCNB3 |
| TissGeneDrug for CCNB3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CCNB3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1261473 | Sarcoma | 3 | BeFree |
| umls:C0029463 | Osteosarcoma | 2 | BeFree,CTD_human |
| umls:C0553581 | Round cell sarcoma | 2 | BeFree |
| umls:C0037579 | Soft Tissue Neoplasms | 1 | BeFree |
| umls:C0553580 | Ewings sarcoma | 1 | BeFree |
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