TissGeneSummary for CNTNAP4 |
Gene summary |
Basic gene information | Gene symbol | CNTNAP4 |
Gene name | contactin associated protein-like 4 | |
Synonyms | CASPR4 | |
Cytomap | UCSC genome browser: 16q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_033401.3, NM_138994.3, | |
Description | cell recognition molecule Caspr4cell recognition protein CASPR4contactin-associated protein-like 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610518 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152910 | ||
HPRD : 13079 | ||
Vega : OTTHUMG00000137617 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNTNAP4 | |
BioGPS: 85445 | ||
Pathway | NCI Pathway Interaction Database: CNTNAP4 | |
KEGG: CNTNAP4 | ||
REACTOME: CNTNAP4 | ||
Pathway Commons: CNTNAP4 | ||
Context | iHOP: CNTNAP4 | |
ligand binding site mutation search in PubMed: CNTNAP4 | ||
UCL Cancer Institute: CNTNAP4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of CNTNAP4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CNTNAP4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.999352268 | -1.362600268 | -1.636752 | 6.66E-06 | 2.18E-05 |
PRAD | -2.084653115 | -0.959574268 | -1.125078846 | 0.00108 | 0.003442788 |
COAD | -3.052197345 | -1.975335807 | -1.076861538 | 0.000256 | 0.000847275 |
LIHC | -0.953828268 | -2.835488268 | 1.88166 | 3.19E-05 | 0.000121735 |
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TissGene-miRNA for CNTNAP4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CNTNAP4 |
TissGeneSNV for CNTNAP4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S534F | SKCM | 3 |
p.W161* | SKCM | 3 |
p.N670H | MESO | 3 |
p.E944K | SKCM | 2 |
p.G74E | SKCM | 2 |
p.D1082E | PCPG | 2 |
p.H1031Y | SKCM | 2 |
p.S255F | SKCM | 2 |
p.E318D | UCEC | 2 |
p.Q1085* | SKCM | 2 |
p.G655R | SKCM | 2 |
p.A1088V | UCEC | 2 |
p.S715L | SKCM | 2 |
p.L60M | LUAD | 2 |
p.G727R | SKCM | 2 |
p.L145I | LUAD | 2 |
p.F909L | UCEC | 2 |
p.G727E | SKCM | 2 |
p.R670W | COAD | 2 |
p.S320L | SKCM | 2 |
p.G98E | SKCM | 2 |
p.R932W | SKCM | 2 |
p.A829T | READ | 2 |
p.S613N | LUAD | 1 |
p.Q1013X | SKCM | 1 |
p.G560S | LIHC | 1 |
p.D1188N | BLCA | 1 |
p.I1106V | STAD | 1 |
p.G1032S | HNSC | 1 |
p.P507L | SKCM | 1 |
p.K1217X | SKCM | 1 |
p.Q277H | LUAD | 1 |
p.G141S | SKCM | 1 |
p.I1163T | STAD | 1 |
p.E591X | READ | 1 |
p.P374L | PAAD | 1 |
p.E374K | SKCM | 1 |
p.G179R | GBM | 1 |
p.L219P | SKCM | 1 |
p.G965W | LUAD | 1 |
p.P158H | BLCA | 1 |
p.V1057L | HNSC | 1 |
p.S1239T | ESCA | 1 |
p.H959Y | PAAD | 1 |
p.E872D | ESCA | 1 |
p.P298L | PAAD | 1 |
p.F107C | STAD | 1 |
p.T1155S | LUAD | 1 |
p.H1031Y | PAAD | 1 |
p.E684X | READ | 1 |
p.S1066Y | BLCA | 1 |
p.D497H | LUAD | 1 |
p.D90N | SKCM | 1 |
p.R1232I | LUSC | 1 |
p.S986N | BRCA | 1 |
p.L751S | SKCM | 1 |
p.D1189N | BLCA | 1 |
p.I1236T | STAD | 1 |
p.T286K | LUAD | 1 |
p.G439E | GBM | 1 |
p.G600* | LUAD | 1 |
p.S545* | HNSC | 1 |
p.P774L | STAD | 1 |
p.C664* | UCEC | 1 |
p.C736* | LUAD | 1 |
p.C514* | HNSC | 1 |
p.G893E | SKCM | 1 |
p.S717P | TGCT | 1 |
p.P1015L | SKCM | 1 |
p.S304F | SKCM | 1 |
p.S643L | SKCM | 1 |
p.P847L | STAD | 1 |
p.K1289* | SKCM | 1 |
p.L1068P | KIRP | 1 |
p.R599C | COAD | 1 |
p.S1167T | ESCA | 1 |
p.I536V | LIHC | 1 |
p.P370L | PAAD | 1 |
p.S714C | CESC | 1 |
p.L833* | LUAD | 1 |
p.W452C | LUAD | 1 |
p.S515F | UCEC | 1 |
p.R1268K | SKCM | 1 |
p.S610L | CESC | 1 |
p.A1173T | LUSC | 1 |
p.G655E | SKCM | 1 |
p.E1112A | STAD | 1 |
p.P979S | STAD | 1 |
p.R1277K | SKCM | 1 |
p.D138E | LUAD | 1 |
p.C725Y | LUSC | 1 |
p.G509V | COAD | 1 |
p.L993I | COAD | 1 |
p.D102A | DLBC | 1 |
p.C31F | LUAD | 1 |
p.Q277* | SKCM | 1 |
p.A753S | LUAD | 1 |
p.Q197H | LUAD | 1 |
p.T902S | LUSC | 1 |
p.E1039A | STAD | 1 |
p.A350V | UCEC | 1 |
p.L679S | SKCM | 1 |
p.Q713* | UCEC | 1 |
p.L508V | LUAD | 1 |
p.N728Y | SKCM | 1 |
p.P383R | LUAD | 1 |
p.G528R | SKCM | 1 |
p.D497V | LUAD | 1 |
p.R282H | GBM | 1 |
p.P828L | SKCM | 1 |
p.M939I | LUAD | 1 |
p.Q1085E | HNSC | 1 |
p.E289K | SKCM | 1 |
p.Q412* | SKCM | 1 |
p.E160K | LUAD | 1 |
p.C657G | COAD | 1 |
p.L1231I | BLCA | 1 |
p.S201G | STAD | 1 |
p.P906S | STAD | 1 |
p.S175P | KIRC | 1 |
p.H1035Y | PAAD | 1 |
p.L889F | HNSC | 1 |
p.A111S | ESCA | 1 |
p.T91I | SKCM | 1 |
p.G1223E | SKCM | 1 |
p.P1189L | SKCM | 1 |
p.Y662H | STAD | 1 |
p.L437V | ESCA | 1 |
p.F1251V | LUAD | 1 |
p.F112V | PAAD | 1 |
p.A1284G | LUAD | 1 |
p.G175R | LUAD | 1 |
p.R145I | LUAD | 1 |
p.S1023F | SKCM | 1 |
p.P1117L | SKCM | 1 |
p.S414L | KIRC | 1 |
p.A901T | BLCA | 1 |
p.P1205L | SKCM | 1 |
p.R402Q | OV | 1 |
p.E873K | UCEC | 1 |
p.E1090* | LUSC | 1 |
p.R144I | LUAD | 1 |
p.F116V | PAAD | 1 |
p.A1027V | SKCM | 1 |
p.I1263V | LIHC | 1 |
p.D743H | ACC | 1 |
p.E394D | UCEC | 1 |
p.S51C | LUAD | 1 |
p.L243P | SKCM | 1 |
p.V263E | COAD | 1 |
p.S1067C | HNSC | 1 |
p.P622T | LUSC | 1 |
p.G857D | UCEC | 1 |
p.P366T | THYM | 1 |
p.S184Y | UCEC | 1 |
p.M88I | SKCM | 1 |
p.D193H | LIHC | 1 |
p.P900L | SKCM | 1 |
p.Y1007C | THYM | 1 |
p.S852L | SKCM | 1 |
p.H293Y | BLCA | 1 |
p.M940I | LUAD | 1 |
p.T749P | SKCM | 1 |
p.L412P | STAD | 1 |
p.Y710* | LUAD | 1 |
p.G971R | SKCM | 1 |
p.E317X | ACC | 1 |
p.S45R | LGG | 1 |
p.P1087L | SKCM | 1 |
p.T623A | COAD | 1 |
p.S643L | UCEC | 1 |
p.G165S | SKCM | 1 |
p.T848M | PAAD | 1 |
p.A1264P | LUSC | 1 |
p.S194F | LUSC | 1 |
p.E446K | SKCM | 1 |
p.I1033V | STAD | 1 |
p.G416S | COAD | 1 |
p.G578R | LUAD | 1 |
p.T67I | SKCM | 1 |
p.E1213K | SKCM | 1 |
p.G615C | LUAD | 1 |
p.M360L | PAAD | 1 |
p.L993I | BRCA | 1 |
p.L680P | PRAD | 1 |
p.F132C | STAD | 1 |
p.D385E | LUAD | 1 |
p.L752P | PRAD | 1 |
p.S368F | SKCM | 1 |
p.T287K | LUAD | 1 |
p.C985Y | LUAD | 1 |
p.E410K | HNSC | 1 |
p.M939K | SKCM | 1 |
p.R716H | BRCA | 1 |
p.P55L | SKCM | 1 |
p.V1145L | LUSC | 1 |
p.F1043C | UCEC | 1 |
p.E1207D | UCS | 1 |
p.V25M | LGG | 1 |
p.M87V | STAD | 1 |
p.S994Y | UCEC | 1 |
p.Y432* | HNSC | 1 |
p.H1103Y | SARC | 1 |
p.R398Q | CESC | 1 |
p.C491X | COAD | 1 |
p.D815H | ACC | 1 |
p.Y5F | KIRC | 1 |
p.A998S | COAD | 1 |
p.G750V | LUAD | 1 |
p.L722I | UCEC | 1 |
p.S790* | LUAD | 1 |
p.L61M | LUAD | 1 |
p.Q1265H | LUAD | 1 |
p.I422M | LUSC | 1 |
p.V953L | LUAD | 1 |
p.S486L | KIRC | 1 |
p.P163T | HNSC | 1 |
p.S199P | KIRC | 1 |
p.C923X | THYM | 1 |
p.S175F | SKCM | 1 |
p.R599K | HNSC | 1 |
p.I1250F | BLCA | 1 |
p.D1080Y | BRCA | 1 |
p.A92S | LUAD | 1 |
p.I1191V | LIHC | 1 |
p.F1251L | MESO | 1 |
p.I608V | LIHC | 1 |
p.S456F | SKCM | 1 |
p.K749N | ACC | 1 |
p.H295Y | SKCM | 1 |
p.H877D | LUAD | 1 |
p.K140X | THYM | 1 |
p.G416D | STAD | 1 |
p.W711L | BLCA | 1 |
p.Y964F | BLCA | 1 |
p.A93S | LUAD | 1 |
p.G712E | SKCM | 1 |
p.G1033S | HNSC | 1 |
p.R174* | LUSC | 1 |
p.E48K | SKCM | 1 |
p.V937M | OV | 1 |
p.D217H | LIHC | 1 |
p.H585D | SARC | 1 |
p.G919R | BLCA | 1 |
p.D741A | LUAD | 1 |
p.D526Y | LUAD | 1 |
p.S1066Y | LUAD | 1 |
p.A814T | PRAD | 1 |
p.P55S | STAD | 1 |
p.T922I | LUAD | 1 |
p.M356L | PAAD | 1 |
p.G526D | LUSC | 1 |
p.E48K | BLCA | 1 |
p.D243E | BRCA | 1 |
p.L365V | ESCA | 1 |
p.I1107L | SKCM | 1 |
p.G435E | SKCM | 1 |
p.Y735H | STAD | 1 |
p.E799K | SKCM | 1 |
p.Y1079C | THYM | 1 |
p.M867K | SKCM | 1 |
p.S538Y | LUSC | 1 |
p.E678* | LUAD | 1 |
p.N875K | LUSC | 1 |
p.L14V | DLBC | 1 |
p.G488S | LIHC | 1 |
p.K821N | ACC | 1 |
p.E628* | LUAD | 1 |
p.N1010H | COAD | 1 |
p.V299L | CHOL | 1 |
p.R844C | BLCA | 1 |
p.D384E | LUAD | 1 |
p.G441R | SKCM | 1 |
p.K356T | STAD | 1 |
p.L646I | UCEC | 1 |
p.P384R | LUAD | 1 |
p.G640E | SKCM | 1 |
p.M1034I | SKCM | 1 |
p.N286H | UCEC | 1 |
p.P435L | SKCM | 1 |
p.R698Q | READ | 1 |
p.S1066C | HNSC | 1 |
p.S132L | HNSC | 1 |
p.E1279D | UCS | 1 |
p.G517* | LUSC | 1 |
p.V643F | ESCA | 1 |
p.G1073D | SKCM | 1 |
p.E389* | ACC | 1 |
p.G102E | LUSC | 1 |
p.P163L | SKCM | 1 |
p.R146Q | COAD | 1 |
p.Q634L | LIHC | 1 |
p.S1007L | SKCM | 1 |
p.S660Y | UCEC | 1 |
p.V455L | BLCA | 1 |
p.G564R | LUSC | 1 |
p.E657K | SKCM | 1 |
p.S795F | SKCM | 1 |
p.V855E | LUAD | 1 |
p.E944D | ESCA | 1 |
p.D472E | BRCA | 1 |
p.E1086* | LUAD | 1 |
p.D114N | SKCM | 1 |
p.R882M | SKCM | 1 |
p.F1060S | LUSC | 1 |
p.L1065V | LUAD | 1 |
p.R326* | UCEC | 1 |
p.E730Q | LUSC | 1 |
p.C515* | HNSC | 1 |
p.A1027D | CESC | 1 |
p.F747L | STAD | 1 |
p.S1290G | ESCA | 1 |
p.S753* | UCEC | 1 |
p.P383T | LUAD | 1 |
p.D424N | SKCM | 1 |
p.S462F | SKCM | 1 |
p.R742Q | SKCM | 1 |
p.C30F | LUAD | 1 |
p.S199F | SKCM | 1 |
p.D342Y | STAD | 1 |
p.L455Q | KIRC | 1 |
p.D743Y | STAD | 1 |
p.M111V | STAD | 1 |
p.T920M | PAAD | 1 |
p.Q924H | LUAD | 1 |
p.E1273* | UCEC | 1 |
p.R924K | BLCA | 1 |
p.K428T | STAD | 1 |
p.R1205K | SKCM | 1 |
p.Q562L | LIHC | 1 |
p.N94H | UCEC | 1 |
p.A1028T | STAD | 1 |
p.V116D | LAML | 1 |
p.M590T | LIHC | 1 |
p.S789* | LUAD | 1 |
p.Y118H | COAD | 1 |
p.D344G | STAD | 1 |
p.A473G | THCA | 1 |
p.E727K | SKCM | 1 |
p.E585K | LAML | 1 |
p.Q1266H | LUAD | 1 |
p.D205Y | CESC | 1 |
p.Q412* | BLCA | 1 |
p.G513R | SKCM | 1 |
p.V455F | LUAD | 1 |
p.D32N | STAD | 1 |
p.V571F | ESCA | 1 |
p.T923I | LUAD | 1 |
p.G600R | SKCM | 1 |
p.Y5H | BRCA | 1 |
p.S486L | SKCM | 1 |
p.S1218G | ESCA | 1 |
p.R273W | COAD | 1 |
p.R63T | HNSC | 1 |
p.Q733K | CESC | 1 |
p.S376F | SKCM | 1 |
p.S52C | LUAD | 1 |
p.I1035L | SKCM | 1 |
p.R923K | BLCA | 1 |
p.A814V | SARC | 1 |
p.M214K | SKCM | 1 |
p.S789P | TGCT | 1 |
p.E374K | UCEC | 1 |
p.T753N | LUSC | 1 |
p.R600K | HNSC | 1 |
p.P1115T | BRCA | 1 |
p.G488D | STAD | 1 |
p.D1082E | COAD | 1 |
p.F820L | STAD | 1 |
p.P252L | SKCM | 1 |
p.R599L | UCEC | 1 |
p.Q925H | LUAD | 1 |
p.G187V | LUAD | 1 |
p.A582P | LUAD | 1 |
p.E23K | UCEC | 1 |
p.S177G | STAD | 1 |
p.S592L | SARC | 1 |
p.Y681H | SKCM | 1 |
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TissGeneCNV for CNTNAP4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNTNAP4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CNTNAP4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNTNAP4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNTNAP4 |
TissGeneDrug for CNTNAP4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNTNAP4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0339573 | Glaucoma, Primary Open Angle | 1 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | GAD |