TissGeneSummary for DNAJC5B |
Gene summary |
Basic gene information | Gene symbol | DNAJC5B |
Gene name | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | |
Synonyms | CSP-beta | |
Cytomap | UCSC genome browser: 8q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_033105.4, | |
Description | beta cysteine string proteinbeta-CSPcysteine string protein betadnaJ homolog subfamily C member 5BdnaJ homolog subfamily C member X | |
Modification date | 20141207 | |
dbXrefs | MIM : 613945 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147570 | ||
HPRD : 07474 | ||
Vega : OTTHUMG00000164470 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DNAJC5B | |
BioGPS: 85479 | ||
Pathway | NCI Pathway Interaction Database: DNAJC5B | |
KEGG: DNAJC5B | ||
REACTOME: DNAJC5B | ||
Pathway Commons: DNAJC5B | ||
Context | iHOP: DNAJC5B | |
ligand binding site mutation search in PubMed: DNAJC5B | ||
UCL Cancer Institute: DNAJC5B | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DNAJC5B | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DNAJC5B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.633619988 | -2.384342512 | 3.0179625 | 7.19E-10 | 6.89E-09 |
KIRC | 0.913163738 | -2.259772373 | 3.172936111 | 3.97E-26 | 5.26E-25 |
LUSC | 0.871257855 | 3.18566962 | -2.314411765 | 9.48E-12 | 3.97E-11 |
BRCA | 0.245863738 | -1.109172227 | 1.355035965 | 3.96E-11 | 1.61E-10 |
LUAD | 1.803548221 | 3.165243048 | -1.361694828 | 3.20E-07 | 1.16E-06 |
KICH | -1.031392262 | -2.157176262 | 1.125784 | 0.00159 | 0.003318523 |
STAD | 0.502966863 | -1.132361262 | 1.635328125 | 8.34E-05 | 0.000655827 |
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TissGene-miRNA for DNAJC5B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DNAJC5B |
TissGeneSNV for DNAJC5B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E22K | SKCM | 6 |
p.E97K | SKCM | 3 |
p.A69T | STAD | 2 |
p.E160K | SKCM | 2 |
p.G191A | LUAD | 1 |
p.S107R | STAD | 1 |
p.S199F | SKCM | 1 |
p.A91D | LUAD | 1 |
p.N182S | SARC | 1 |
p.G25A | BLCA | 1 |
p.G95E | CESC | 1 |
p.E167K | SKCM | 1 |
p.G17E | SKCM | 1 |
p.S14* | LUAD | 1 |
p.E143K | HNSC | 1 |
p.R193* | SKCM | 1 |
p.N65T | SKCM | 1 |
p.E97K | READ | 1 |
p.S144L | SKCM | 1 |
p.K82Q | HNSC | 1 |
p.G118D | UCEC | 1 |
p.E34Q | BLCA | 1 |
p.S85L | PAAD | 1 |
p.T197S | PRAD | 1 |
p.S154T | COAD | 1 |
p.T15K | LUAD | 1 |
p.R193Q | SKCM | 1 |
p.A67T | UCEC | 1 |
p.A67T | LUAD | 1 |
p.S192C | LUAD | 1 |
p.I5T | STAD | 1 |
p.G191E | UCEC | 1 |
p.D54N | SKCM | 1 |
p.G29E | SKCM | 1 |
p.A43S | LUAD | 1 |
p.I188M | UCEC | 1 |
p.D81N | SKCM | 1 |
p.S154F | HNSC | 1 |
p.E33K | SKCM | 1 |
p.A91E | LUAD | 1 |
p.M166I | SKCM | 1 |
p.D96G | STAD | 1 |
p.P52S | SKCM | 1 |
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TissGeneCNV for DNAJC5B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DNAJC5B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI045962 | PDE9A-DNAJC5B | chr21:44110439 | chr8:67011191 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0AS-01A | TSC22D1-DNAJC5B | In-frame | Chr13:45147299 | Chr8:66988895 |
TCGAfusionPortal | PRADA | OV | TCGA-24-1548-01A | SGK3-DNAJC5B | In-frame | Chr8:67710860 | Chr8:66992612 |
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TissGeneNet for DNAJC5B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DNAJC5B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DNAJC5B |
TissGeneDrug for DNAJC5B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DNAJC5B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |