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| TissGeneSummary for SERPINA6 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA6 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | |
| Synonyms | CBG | |
| Cytomap | UCSC genome browser: 14q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001756.3, | |
| Description | corticosteroid binding globulincorticosteroid-binding globulinserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6serpin A6transcortin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 122500 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170099 | ||
| HPRD : 00419 | ||
| Vega : OTTHUMG00000171346 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA6 | |
| BioGPS: 866 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA6 | |
| KEGG: SERPINA6 | ||
| REACTOME: SERPINA6 | ||
| Pathway Commons: SERPINA6 | ||
| Context | iHOP: SERPINA6 | |
| ligand binding site mutation search in PubMed: SERPINA6 | ||
| UCL Cancer Institute: SERPINA6 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SERPINA6 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SERPINA6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 9.861272131 | 11.03748213 | -1.17621 | 2.20E-05 | 8.62E-05 |
| KICH | -1.885203869 | 5.886108131 | -7.771312 | 1.05E-22 | 1.29E-20 |
| ESCA | 0.194902677 | -2.813942778 | 3.008845455 | 0.00392 | 0.034275765 |
| COAD | 1.170182746 | 2.888351977 | -1.718169231 | 0.00718 | 0.016455418 |
| LUAD | -2.490348421 | -1.446758765 | -1.043589655 | 0.000248 | 0.000588017 |
| KIRC | 4.326956464 | 5.650717576 | -1.323761111 | 5.62E-05 | 0.000122157 |
| Top |
| TissGene-miRNA for SERPINA6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA6 |
| TissGeneSNV for SERPINA6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L133F | SKCM | 1 |
| p.W18* | SKCM | 1 |
| p.M255I | ESCA | 1 |
| p.T305A | ACC | 1 |
| p.Q381K | LUAD | 1 |
| p.T392I | SKCM | 1 |
| p.S167N | ESCA | 1 |
| p.T364N | THYM | 1 |
| p.M234T | LUAD | 1 |
| p.W163R | STAD | 1 |
| p.D314N | SKCM | 1 |
| p.M72I | PAAD | 1 |
| p.V196I | GBM | 1 |
| p.L90I | SKCM | 1 |
| p.D224N | COAD | 1 |
| p.V276F | LUAD | 1 |
| p.E138K | BLCA | 1 |
| p.L3F | PRAD | 1 |
| p.E99K | CESC | 1 |
| p.S246L | GBM | 1 |
| p.S342* | LUSC | 1 |
| p.R378C | STAD | 1 |
| p.T364N | LUAD | 1 |
| p.R86W | READ | 1 |
| p.M273I | HNSC | 1 |
| p.F397L | COAD | 1 |
| p.S237L | BLCA | 1 |
| p.A290T | STAD | 1 |
| p.T19N | SKCM | 1 |
| p.R378S | LUAD | 1 |
| p.L5M | UCEC | 1 |
| p.V44A | HNSC | 1 |
| p.L213M | HNSC | 1 |
| p.I147N | UCEC | 1 |
| p.T284M | STAD | 1 |
| p.M32I | SKCM | 1 |
| p.G94S | SKCM | 1 |
| p.G357D | SKCM | 1 |
| p.T335A | UCEC | 1 |
| p.A399V | BLCA | 1 |
| p.F221I | LUAD | 1 |
| p.E225X | THYM | 1 |
| p.L396P | LUAD | 1 |
| p.D134E | KIRP | 1 |
| p.D134G | LGG | 1 |
| p.L324F | LUAD | 1 |
| p.A40T | UCEC | 1 |
| p.A164S | LUAD | 1 |
| p.S394R | LUSC | 1 |
| p.D337H | LUAD | 1 |
| p.P59S | SKCM | 1 |
| p.D314Y | LIHC | 1 |
| p.L398P | PAAD | 1 |
| p.G313E | SKCM | 1 |
| p.G205S | SKCM | 1 |
| p.S246A | COAD | 1 |
| p.H347Y | SKCM | 1 |
| p.P268L | LUAD | 1 |
| p.A87D | LUAD | 1 |
| p.V258M | STAD | 1 |
| p.P59H | LUAD | 1 |
| p.T335A | COAD | 1 |
| p.T360I | UCEC | 1 |
| p.G108S | SKCM | 1 |
| Top |
| TissGeneCNV for SERPINA6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SERPINA6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SERPINA6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SERPINA6 |
| TissGeneDrug for SERPINA6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0015672 | Fatigue | 8 | BeFree,LHGDN |
| umls:C0028754 | Obesity | 5 | BeFree,GAD |
| umls:C1852529 | Corticosteroid-Binding Globulin Deficiency | 5 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0032002 | Pituitary Diseases | 4 | BeFree |
| umls:C0015674 | Chronic Fatigue Syndrome | 2 | BeFree,GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 2 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 2 | BeFree,GAD |
| umls:C0206624 | Hepatoblastoma | 2 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0000809 | Abortion, Habitual | 1 | GAD |
| umls:C0002793 | Anaplasia | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0020550 | Hyperthyroidism | 1 | BeFree |
| umls:C0021361 | Female infertility | 1 | GAD |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0026858 | Musculoskeletal Pain | 1 | GAD |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0033931 | Psychophysiologic Disorders | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0150055 | Chronic pain | 1 | BeFree |
| umls:C0221757 | alpha 1-Antitrypsin Deficiency | 1 | GAD |
| umls:C0271583 | ACTH Deficiency, Isolated | 1 | BeFree |
| umls:C0271738 | Hypocortisolism secondary to another disorder | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C3495559 | Juvenile arthritis | 1 | GAD |
| umls:C3495801 | Granulomatosis with polyangiitis | 1 | GAD |
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