TissGeneSummary for ADAM21 |
Gene summary |
Basic gene information | Gene symbol | ADAM21 |
Gene name | ADAM metallopeptidase domain 21 | |
Synonyms | ADAM 21|ADAM31 | |
Cytomap | UCSC genome browser: 14q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_003813.3, | |
Description | ADAM metallopeptidase domain 21, preproproteina disintegrin and metalloproteinase domain 21disintegrin and metalloproteinase domain-containing protein 21 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603713 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139985 | ||
HPRD : 04755 | ||
Vega : OTTHUMG00000171328 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM21 | |
BioGPS: 8747 | ||
Pathway | NCI Pathway Interaction Database: ADAM21 | |
KEGG: ADAM21 | ||
REACTOME: ADAM21 | ||
Pathway Commons: ADAM21 | ||
Context | iHOP: ADAM21 | |
ligand binding site mutation search in PubMed: ADAM21 | ||
UCL Cancer Institute: ADAM21 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAM21 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM21 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.33456761 | 0.843189335 | -1.177756944 | 7.44E-25 | 8.82E-24 |
LIHC | 0.635534946 | -0.580971054 | 1.216506 | 2.52E-07 | 1.57E-06 |
PRAD | 1.572537946 | -0.043487054 | 1.616025 | 1.27E-08 | 1.54E-07 |
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TissGene-miRNA for ADAM21 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM21 |
TissGeneSNV for ADAM21 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F129C | CESC | 2 |
p.D278N | SKCM | 2 |
p.R133X | UVM | 2 |
p.G264E | SKCM | 2 |
p.P713L | SKCM | 2 |
p.E177K | UCEC | 1 |
p.H72Y | HNSC | 1 |
p.P106L | KIRC | 1 |
p.F154L | PRAD | 1 |
p.W261S | SKCM | 1 |
p.S602F | BLCA | 1 |
p.R66W | READ | 1 |
p.E402K | COAD | 1 |
p.D609N | SKCM | 1 |
p.A676S | ESCA | 1 |
p.E715X | COAD | 1 |
p.R66W | ESCA | 1 |
p.E188Q | BLCA | 1 |
p.E532K | SKCM | 1 |
p.S199F | ACC | 1 |
p.S271N | ESCA | 1 |
p.A55G | SKCM | 1 |
p.E715K | SKCM | 1 |
p.T346M | UCEC | 1 |
p.P58S | SKCM | 1 |
p.S199F | THYM | 1 |
p.Q35K | SKCM | 1 |
p.Q70E | STAD | 1 |
p.I304T | HNSC | 1 |
p.L684S | HNSC | 1 |
p.P685S | THYM | 1 |
p.P119L | SKCM | 1 |
p.E373Q | HNSC | 1 |
p.R317H | UCEC | 1 |
p.N301H | UCEC | 1 |
p.S54I | LGG | 1 |
p.S721* | CESC | 1 |
p.P106S | SKCM | 1 |
p.C496R | STAD | 1 |
p.N265Y | KIRC | 1 |
p.R408H | SKCM | 1 |
p.E144K | SKCM | 1 |
p.V135L | CESC | 1 |
p.W261* | SKCM | 1 |
p.G257E | PAAD | 1 |
p.Q350H | CESC | 1 |
p.S302L | SKCM | 1 |
p.S199Y | UCEC | 1 |
p.A117G | COAD | 1 |
p.D570Y | BLCA | 1 |
p.I49V | STAD | 1 |
p.I517M | UCEC | 1 |
p.S199F | ESCA | 1 |
p.G479E | SKCM | 1 |
p.G391E | SARC | 1 |
p.L450F | LGG | 1 |
p.Q663K | LUAD | 1 |
p.E273* | UCEC | 1 |
p.D4H | HNSC | 1 |
p.L46F | CESC | 1 |
p.S199F | THCA | 1 |
p.G323R | SKCM | 1 |
p.G27S | BRCA | 1 |
p.H292L | BLCA | 1 |
p.M245K | BLCA | 1 |
p.V213I | LIHC | 1 |
p.G541C | LUSC | 1 |
p.Q102E | SKCM | 1 |
p.L635H | ACC | 1 |
p.G681E | SKCM | 1 |
p.W18L | CHOL | 1 |
p.M297T | LUSC | 1 |
p.E188Q | LUAD | 1 |
p.D94N | HNSC | 1 |
p.V115M | CHOL | 1 |
p.A445V | LUAD | 1 |
p.Y114H | STAD | 1 |
p.S26F | SKCM | 1 |
p.F67V | BLCA | 1 |
p.Q419E | ESCA | 1 |
p.G537E | SKCM | 1 |
p.A31D | STAD | 1 |
p.N478K | LUAD | 1 |
p.C565Y | TGCT | 1 |
p.S84C | BLCA | 1 |
p.R598K | DLBC | 1 |
p.S39F | SKCM | 1 |
p.D278N | COAD | 1 |
p.H292L | LUSC | 1 |
p.I517F | SKCM | 1 |
p.N265H | UCEC | 1 |
p.S34F | SKCM | 1 |
p.E516D | COAD | 1 |
p.K617M | LUAD | 1 |
p.I148S | STAD | 1 |
p.T589S | KIRC | 1 |
p.A444V | UCEC | 1 |
p.S199F | PAAD | 1 |
p.G134V | STAD | 1 |
p.D557N | LUAD | 1 |
p.A340V | COAD | 1 |
p.G668E | STAD | 1 |
p.G257* | STAD | 1 |
p.E402V | SKCM | 1 |
p.D219A | UCEC | 1 |
p.E402X | COAD | 1 |
p.S84Y | UCS | 1 |
p.R53K | LUAD | 1 |
p.G264E | SARC | 1 |
p.E116K | SKCM | 1 |
p.C446S | HNSC | 1 |
p.I161V | CESC | 1 |
p.V180I | SKCM | 1 |
p.S288P | STAD | 1 |
p.S199F | LUAD | 1 |
p.W282* | SKCM | 1 |
p.E177K | SKCM | 1 |
p.N396Y | LUSC | 1 |
p.E402K | SKCM | 1 |
p.Q536* | BLCA | 1 |
p.A432V | LUSC | 1 |
p.S199F | BLCA | 1 |
p.V48M | SKCM | 1 |
p.I320M | LIHC | 1 |
p.E179K | SKCM | 1 |
p.E516K | SKCM | 1 |
p.G5E | LGG | 1 |
p.S658F | SKCM | 1 |
p.A500S | KIRP | 1 |
p.Q30E | BRCA | 1 |
p.S602C | CESC | 1 |
p.M297T | STAD | 1 |
p.I222M | READ | 1 |
p.R182H | READ | 1 |
p.C433* | LUSC | 1 |
p.R96C | LUAD | 1 |
p.R441K | SKCM | 1 |
p.Q504* | SKCM | 1 |
p.H341R | LUAD | 1 |
p.D454Y | UCEC | 1 |
p.Q263K | STAD | 1 |
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TissGeneCNV for ADAM21 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM21 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADAM21 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM21 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM21 |
TissGeneDrug for ADAM21 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM21 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |