TissGeneSummary for IL1RL2 |
Gene summary |
Basic gene information | Gene symbol | IL1RL2 |
Gene name | interleukin 1 receptor-like 2 | |
Synonyms | IL-1Rrp2|IL-36R|IL1R-rp2|IL1RRP2 | |
Cytomap | UCSC genome browser: 2q12 | |
Type of gene | protein-coding | |
RefGenes | NM_003854.2, | |
Description | IL-1 receptor-related protein 2IL-36 receptorinterleukin-1 receptor-like 2interleukin-1 receptor-related protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604512 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115598 | ||
HPRD : 05150 | ||
Vega : OTTHUMG00000130776 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL1RL2 | |
BioGPS: 8808 | ||
Pathway | NCI Pathway Interaction Database: IL1RL2 | |
KEGG: IL1RL2 | ||
REACTOME: IL1RL2 | ||
Pathway Commons: IL1RL2 | ||
Context | iHOP: IL1RL2 | |
ligand binding site mutation search in PubMed: IL1RL2 | ||
UCL Cancer Institute: IL1RL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSKCM | |
Reference showing the relevant tissue of IL1RL2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for IL1RL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | -1.935212031 | -0.526312031 | -1.4089 | 7.18E-07 | 5.29E-06 |
LUAD | -0.648706129 | -2.816331991 | 2.167625862 | 4.12E-16 | 4.67E-15 |
LUSC | -0.162674588 | -2.208419686 | 2.045745098 | 5.31E-12 | 2.30E-11 |
BRCA | -1.555876032 | -0.301293576 | -1.254582456 | 3.36E-10 | 1.26E-09 |
KIRP | -0.943840397 | 0.535043978 | -1.478884375 | 0.000383 | 0.001154148 |
LIHC | -1.532947647 | -0.081715647 | -1.451232 | 0.000368 | 0.001107491 |
Top |
TissGene-miRNA for IL1RL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for IL1RL2 |
TissGeneSNV for IL1RL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R72I | COAD | 2 |
p.P392L | UCEC | 1 |
p.D362N | LGG | 1 |
p.R557H | SARC | 1 |
p.I11T | SKCM | 1 |
p.P46H | LGG | 1 |
p.S16F | SKCM | 1 |
p.R368Q | SKCM | 1 |
p.F82I | SKCM | 1 |
p.R279Q | BLCA | 1 |
p.L199R | LGG | 1 |
p.D130N | LIHC | 1 |
p.E292A | KIRP | 1 |
p.A510D | SARC | 1 |
p.P313T | UCEC | 1 |
p.S90L | HNSC | 1 |
p.E414D | KIRC | 1 |
p.S396N | PRAD | 1 |
p.K160T | READ | 1 |
p.V442L | LUSC | 1 |
p.R291W | BLCA | 1 |
p.M85I | SKCM | 1 |
p.V214E | UCEC | 1 |
p.Y354F | PRAD | 1 |
p.Q75H | READ | 1 |
p.P45S | SKCM | 1 |
p.P313L | SKCM | 1 |
p.D189N | BRCA | 1 |
p.E86D | SKCM | 1 |
p.P410L | SKCM | 1 |
p.V65M | STAD | 1 |
p.D275A | THYM | 1 |
p.L128I | LIHC | 1 |
p.E86A | SKCM | 1 |
p.G418V | UCEC | 1 |
p.D76N | SKCM | 1 |
p.L550P | COAD | 1 |
p.R72I | KIRC | 1 |
p.C42Y | KIRP | 1 |
p.A194S | LUAD | 1 |
p.E207G | UCEC | 1 |
p.G224E | LUAD | 1 |
p.Q478* | SKCM | 1 |
p.G27R | SKCM | 1 |
p.Q416X | KIRP | 1 |
p.R540W | OV | 1 |
p.Q416* | KIRP | 1 |
p.E440K | SKCM | 1 |
p.K568N | UCEC | 1 |
p.P24A | BRCA | 1 |
p.W87G | SKCM | 1 |
p.A344T | UCEC | 1 |
p.T573M | LAML | 1 |
p.R281I | THYM | 1 |
p.A471T | DLBC | 1 |
p.D379_splice | GBM | 1 |
p.N266S | BRCA | 1 |
p.D256N | SKCM | 1 |
p.H235Y | SKCM | 1 |
p.V208D | SARC | 1 |
p.G340E | SKCM | 1 |
p.E131D | KIRP | 1 |
p.G418V | ESCA | 1 |
p.G21R | SKCM | 1 |
p.H74Q | BRCA | 1 |
p.P64S | SKCM | 1 |
p.L342I | STAD | 1 |
p.K391T | BLCA | 1 |
p.V270M | SKCM | 1 |
p.E492D | UCEC | 1 |
p.W2X | THYM | 1 |
p.S60C | HNSC | 1 |
p.M85I | SARC | 1 |
p.S53N | LGG | 1 |
p.H293L | STAD | 1 |
p.N267S | LUAD | 1 |
p.R533G | STAD | 1 |
p.I486M | SKCM | 1 |
p.G139E | SKCM | 1 |
p.I47T | UCEC | 1 |
p.A385S | LUAD | 1 |
p.G203E | SKCM | 1 |
p.R279Q | SKCM | 1 |
p.G480E | SKCM | 1 |
p.R335Q | UCEC | 1 |
p.G480R | BRCA | 1 |
p.I361T | COAD | 1 |
Top |
TissGeneCNV for IL1RL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for IL1RL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1FD-01A | IL1RL2-IL1R2 | Out-of-frame | Chr2:102828634 | Chr2:102636100 |
Top |
TissGeneNet for IL1RL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for IL1RL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for IL1RL2 |
TissGeneDrug for IL1RL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for IL1RL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029408 | Degenerative polyarthritis | 2 | GAD |
umls:C0007570 | Celiac Disease | 1 | GAD |
umls:C0021818 | Intervertebral Disk Displacement | 1 | GAD |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
umls:C0028797 | Occupational Diseases | 1 | GAD |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0037268 | Skin Abnormalities | 1 | BeFree |
umls:C0151449 | Primary Sj�gren's syndrome | 1 | BeFree |