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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NR1I2
check button Gene summary
Basic gene informationGene symbolNR1I2
Gene namenuclear receptor subfamily 1, group I, member 2
SynonymsBXR|ONR1|PAR|PAR1|PAR2|PARq|PRR|PXR|SAR|SXR
CytomapUCSC genome browser: 3q12-q13.3
Type of geneprotein-coding
RefGenesNM_003889.3,
NM_022002.2,NM_033013.2,
Descriptionnuclear receptor subfamily 1 group I member 2orphan nuclear receptor PAR1orphan nuclear receptor PXRpregnane X nuclear receptor variant 2pregnane X receptorsteroid and xenobiotic receptor
Modification date20141207
dbXrefs MIM : 603065
HGNC : HGNC
Ensembl : ENSG00000144852
HPRD : 04346
Vega : OTTHUMG00000159400
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NR1I2
BioGPS: 8856
PathwayNCI Pathway Interaction Database: NR1I2
KEGG: NR1I2
REACTOME: NR1I2
Pathway Commons: NR1I2
ContextiHOP: NR1I2
ligand binding site mutation search in PubMed: NR1I2
UCL Cancer Institute: NR1I2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of NR1I2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006805xenobiotic metabolic process12578355
GO:0030522intracellular receptor signaling pathway12578355
GO:0042738exogenous drug catabolic process12578355
GO:0042908xenobiotic transport12578355
GO:0045892negative regulation of transcription, DNA-templated11891224
GO:0045893positive regulation of transcription, DNA-templated12578355
GO:0045944positive regulation of transcription from RNA polymerase II promoter11114890
GO:0046618drug export12578355
GO:0006805xenobiotic metabolic process12578355
GO:0030522intracellular receptor signaling pathway12578355
GO:0042738exogenous drug catabolic process12578355
GO:0042908xenobiotic transport12578355
GO:0045892negative regulation of transcription, DNA-templated11891224
GO:0045893positive regulation of transcription, DNA-templated12578355
GO:0045944positive regulation of transcription from RNA polymerase II promoter11114890
GO:0046618drug export12578355


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TissGeneExp for NR1I2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC5.7942576898.446051689-2.6517942.02E-071.31E-06
KICH-1.759230311-0.262510311-1.496722.05E-091.21E-08


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TissGene-miRNA for NR1I2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for NR1I2
TissGeneSNV for NR1I2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V400MSTAD1
p.E120DLUSC1
p.E334DESCA1
p.A318GSTAD1
p.M323VCOAD1
p.W9XSKCM1
p.A318TPAAD1
p.C182YLUAD1
p.G469CACC1
p.A279GSTAD1
p.R401CSKCM1
p.A333TSTAD1
p.E222KCESC1
p.S231NSARC1
p.R187WESCA1
p.W9*SKCM1
p.M243TSTAD1
p.G76VLIHC1
p.R353CTHYM1
p.L424PGBM1
p.G60ESKCM1
p.A294VHNSC1
p.G37DSTAD1
p.A122TSTAD1
p.S153TLIHC1
p.E60DUCEC1
p.I431MBLCA1
p.A279TPAAD1
p.L348ISTAD1
p.G220DSTAD1
p.G278RSKCM1
p.V361MSTAD1
p.C123XKIRC1
p.R410WKIRC1
p.Y51CHNSC1
p.G181DSTAD1
p.E218GHNSC1
p.W9CLUAD1
p.A294TSTAD1
p.D305NBRCA1
p.K89NBLCA1
p.G178XLIHC1
p.G76DSTAD1
p.L138QLUAD1
p.G37VLIHC1
p.S239NUCEC1
p.L397IBLCA1
p.G35DHNSC1
p.L14FSKCM1
p.M282TSTAD1
p.G45ESKCM1
p.M152ILIHC1
p.A83TSTAD1
p.R148WESCA1
p.G215RUCEC1
p.E98KCESC1
p.G134WLGG1
p.M69IBLCA1


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TissGeneCNV for NR1I2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NR1I2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACA314620NR1I2-TMEM246chr3:119511403chr9:104237953


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TissGeneNet for NR1I2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NR1I2, NCOR1, SRC, RXRA, SUMO1, RXRG, NCOR2, FGR, ACTN2, PSMC5, MAPK7, NCOA6, ABCB1, PPARA, PRMT1, ALAS1, ATP6AP1, CYP2C9, CYP3A4, TFAP2C, NFATC4 (tumor)NR1I2, NCOA3, NCOR1, SRC, RXRB, RXRA, CYP3A7, FGR, ACTN2, PSMC5, MAPK7, NOS2, PPARA, PRMT1, PPARGC1A, SUMO3, ATP6AP1, CYP3A4, NUCB2, TFAP2C, NFATC4 (normal)
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COAD (tumor)COAD (normal)
NR1I2, HNF4A, SRC, RXRA, RXRG, CYP3A7, EIF3I, ABCB1, PPARA, PRMT1, PPARGC1A, ALAS1, ATP6AP1, CYP2C9, CYP3A4, NUCB2, TFAP2C, NFATC4, CHMP1A, SDF4, CYP2B6 (tumor)NR1I2, NCOA3, HNF4A, NCOR1, SRC, NR0B2, RXRA, CYP3A7, FGR, ACTN2, NCOA6, ABCB1, PPARA, SUMO3, ATP6AP1, CYP3A4, NUCB2, TFAP2C, SDF4, CYP2B6, SLCO1B1 (normal)
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HNSC (tumor)HNSC (normal)
NR1I2, NR0B2, RXRA, NCOA1, NCOR2, ACTN2, PSMC5, EIF3I, MAPK7, ABCB1, PRMT1, PPARGC1A, SUMO3, TADA3, ATP6AP1, CYP3A4, NFATC4, CHMP1A, POU1F1, SDF4, CYP2B6 (tumor)NR1I2, NCOA3, HNF4A, ONECUT1, RXRB, NR0B2, RXRA, NCOA1, CYP3A7, FGR, EIF3I, MAPK7, ABCB1, NOS2, PRMT1, TADA3, NUCB2, TFAP2C, NFATC4, CHMP1A, CYP2B6 (normal)
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KICH (tumor)KICH (normal)
NR1I2, NCOA3, HNF4A, ONECUT1, SRC, RXRA, CYP3A7, ACTN2, PSMC5, MAPK7, ABCB1, PPARA, PPARGC1A, ALAS1, TADA3, CYP3A4, NUCB2, TFAP2C, NFATC4, SDF4, CYP2B6 (tumor)NR1I2, HNF4A, RXRB, RXRA, SUMO1, RXRG, NCOR2, CYP3A7, FGR, PSMC5, EIF3I, ABCB1, NOS2, PRMT1, ALAS1, SUMO3, TFAP2C, NFATC4, CHMP1A, POU1F1, SDF4 (normal)
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KIRC (tumor)KIRC (normal)
NR1I2, HNF4A, ONECUT1, SUMO2, SRC, RXRA, CYP3A7, EIF3I, NCOA6, ABCB1, PPARA, PRMT1, SUMO3, TADA3, ATP6AP1, CYP2C9, CYP3A4, TFAP2C, NFATC4, CHMP1A, CYP2B6 (tumor)NR1I2, NCOA3, HNF4A, SRC, RXRB, NR0B2, NCOA1, FGR, ACTN2, PSMC5, MAPK7, NOS2, PPARGC1A, ALAS1, SUMO3, ATP6AP1, CYP2C9, CHMP1A, SDF4, CYP2B6, SLCO1B1 (normal)
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KIRP (tumor)KIRP (normal)
NR1I2, HNF4A, ONECUT1, SUMO2, RXRA, SUMO1, NCOA1, CYP3A7, FGR, NCOA6, ABCB1, NOS2, PPARA, PRMT1, SUMO3, CYP3A4, NUCB2, TFAP2C, NFATC4, CYP2B6, SLCO1B1 (tumor)NR1I2, HNF4A, ONECUT1, NCOR1, SRC, RXRB, RXRA, SUMO1, NCOA1, ACTN2, MAPK7, ABCB1, NOS2, PRMT1, ALAS1, ATP6AP1, CYP2C9, NFATC4, POU1F1, SDF4, CYP2B6 (normal)
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LIHC (tumor)LIHC (normal)
NR1I2, NCOA3, HNF4A, ONECUT1, SUMO2, NCOR1, SRC, RXRB, NR0B2, RXRA, NCOR2, FGR, PSMC5, PPARA, PRMT1, CYP2C9, CYP3A4, NFATC4, SDF4, CYP2B6, SLCO1B1 (tumor)NR1I2, HNF4A, SUMO2, SRC, NR0B2, RXRA, RXRG, CYP3A7, MAPK7, ABCB1, PPARA, PRMT1, PPARGC1A, ALAS1, SUMO3, ATP6AP1, CYP2C9, CYP3A4, NFATC4, CYP2B6, SLCO1B1 (normal)
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LUAD (tumor)LUAD (normal)
NR1I2, NCOA3, HNF4A, SUMO2, NCOR1, SRC, RXRB, RXRA, SUMO1, NCOA1, NCOR2, ACTN2, EIF3I, MAPK7, NCOA6, PPARA, SUMO3, TFAP2C, NFATC4, CYP2B6, SLCO1B1 (tumor)NR1I2, HNF4A, SUMO2, SRC, NR0B2, SUMO1, RXRG, CYP3A7, FGR, ACTN2, PSMC5, EIF3I, ABCB1, ALAS1, SUMO3, TADA3, CYP2C9, CYP3A4, TFAP2C, SDF4, CYP2B6 (normal)
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LUSC (tumor)LUSC (normal)
NR1I2, HNF4A, RXRB, NR0B2, NCOA1, NCOR2, FGR, ACTN2, PSMC5, MAPK7, NOS2, PPARGC1A, TADA3, ATP6AP1, CYP2C9, CYP3A4, NUCB2, TFAP2C, POU1F1, SDF4, CYP2B6 (tumor)NR1I2, HNF4A, ONECUT1, RXRB, NR0B2, RXRA, NCOA1, RXRG, CYP3A7, FGR, ACTN2, ABCB1, NOS2, PPARGC1A, ATP6AP1, CYP2C9, CYP3A4, TFAP2C, NFATC4, CHMP1A, CYP2B6 (normal)
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PRAD (tumor)PRAD (normal)
NR1I2, NCOA3, SUMO2, SRC, SUMO1, RXRG, ACTN2, EIF3I, NCOA6, ABCB1, PPARGC1A, SUMO3, TADA3, ATP6AP1, CYP3A4, NUCB2, TFAP2C, NFATC4, CHMP1A, SDF4, CYP2B6 (tumor)NR1I2, NCOA3, NCOR1, SRC, RXRA, SUMO1, NCOA1, RXRG, NCOR2, FGR, ACTN2, MAPK7, ABCB1, PPARGC1A, ALAS1, ATP6AP1, CYP3A4, TFAP2C, NFATC4, CHMP1A, CYP2B6 (normal)
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STAD (tumor)STAD (normal)
NR1I2, NCOA3, HNF4A, ONECUT1, SRC, NR0B2, CYP3A7, PSMC5, MAPK7, ABCB1, NOS2, ALAS1, SUMO3, TADA3, CYP2C9, CYP3A4, NUCB2, TFAP2C, CHMP1A, SDF4, CYP2B6 (tumor)NR1I2, HNF4A, SUMO2, NCOR1, SRC, RXRB, NR0B2, SUMO1, CYP3A7, PSMC5, NCOA6, ABCB1, NOS2, PPARA, PRMT1, PPARGC1A, TADA3, CYP2C9, CYP3A4, NUCB2, CYP2B6 (normal)
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THCA (tumor)THCA (normal)
NR1I2, NCOA3, ONECUT1, SRC, RXRA, NCOR2, FGR, MAPK7, NCOA6, ABCB1, PPARA, PRMT1, PPARGC1A, SUMO3, TADA3, CYP2C9, CYP3A4, NFATC4, CHMP1A, POU1F1, SDF4 (tumor)NR1I2, NCOA3, HNF4A, SRC, RXRB, NCOA1, RXRG, FGR, MAPK7, NCOA6, PPARA, PRMT1, PPARGC1A, ALAS1, SUMO3, TADA3, ATP6AP1, NUCB2, NFATC4, SDF4, SLCO1B1 (normal)
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TissGeneProg for NR1I2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NR1I2
TissGeneDrug for NR1I2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NR1I2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast26BeFree,GAD
umls:C0678222Breast Carcinoma25BeFree
umls:C0027627Neoplasm Metastasis19BeFree
umls:C0021390Inflammatory Bowel Diseases15BeFree,GAD
umls:C2239176Liver carcinoma15BeFree
umls:C0600139Prostate carcinoma14BeFree
umls:C0376358Malignant neoplasm of prostate13BeFree
umls:C0007102Malignant tumor of colon10BeFree
umls:C0009324Ulcerative Colitis10BeFree,GAD,LHGDN
umls:C0265309Leri-Weill dyschondrosteosis10BeFree
umls:C0699790Colon Carcinoma10BeFree
umls:C0003873Rheumatoid Arthritis9BeFree
umls:C0010346Crohn Disease8BeFree,GAD,LHGDN
umls:C0013336Dwarfism8BeFree
umls:C0596263Carcinogenesis8BeFree
umls:C0009402Colorectal Carcinoma7BeFree
umls:C1458155Mammary Neoplasms7BeFree,GAD,LHGDN
umls:C1527249Colorectal Cancer7BeFree,GAD
umls:C0003864Arthritis6BeFree
umls:C0025202melanoma6BeFree
umls:C0001418Adenocarcinoma5BeFree,CTD_human
umls:C0008370Cholestasis5BeFree
umls:C0019693HIV Infections5BeFree,GAD
umls:C0029408Degenerative polyarthritis5BeFree
umls:C0242379Malignant neoplasm of lung5BeFree,GAD
umls:C0009375Colonic Neoplasms4BeFree
umls:C0021053Immune System Diseases4BeFree
umls:C0023903Liver neoplasms4BeFree
umls:C0024121Lung Neoplasms4BeFree
umls:C0024141Lupus Erythematosus, Systemic4BeFree
umls:C0178874Tumor Progression4BeFree
umls:C0235974Pancreatic carcinoma4BeFree
umls:C0684249Carcinoma of lung4BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis4BeFree
umls:C0002395Alzheimer's Disease3BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0004096Asthma3BeFree
umls:C0004153Atherosclerosis3BeFree
umls:C0007103Malignant neoplasm of endometrium3BeFree
umls:C0009319Colitis3BeFree
umls:C0011849Diabetes Mellitus3BeFree,CTD_human
umls:C0014544Epilepsy3BeFree,GAD
umls:C0024623Malignant neoplasm of stomach3BeFree
umls:C0025517Metabolic Diseases3BeFree
umls:C0028754Obesity3BeFree,CTD_human
umls:C0029925Ovarian Carcinoma3BeFree
umls:C0032285Pneumonia3BeFree
umls:C0033578Prostatic Neoplasms3BeFree
umls:C0034069Pulmonary Fibrosis3BeFree
umls:C0041408Turner Syndrome3BeFree
umls:C0268318Cholestasis of pregnancy3BeFree
umls:C0338106Adenocarcinoma of colon3BeFree
umls:C0345964Adenoma of lung3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0476089Endometrial Carcinoma3BeFree
umls:C0686619Secondary malignant neoplasm of lymph node3BeFree
umls:C0699791Stomach Carcinoma3BeFree
umls:C0740457Malignant neoplasm of kidney3BeFree
umls:C1168401Squamous cell carcinoma of the head and neck3BeFree
umls:C1378703Renal carcinoma3BeFree
umls:C1883486Uterine Corpus Cancer3BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0007222Cardiovascular Diseases2BeFree
umls:C0008312Primary biliary cirrhosis2BeFree
umls:C0011615Dermatitis, Atopic2BeFree
umls:C0011847Diabetes2BeFree
umls:C0013595Eczema2BeFree
umls:C0014859Esophageal Neoplasms2BeFree,CTD_human
umls:C0015695Fatty Liver2BeFree,CTD_human
umls:C0017168Gastroesophageal reflux disease2BeFree
umls:C0017638Glioma2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0020429Hyperalgesia2BeFree
umls:C0021400Influenza2BeFree
umls:C0022116Ischemia2BeFree
umls:C0023418leukemia2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree,GAD
umls:C0023890Liver Cirrhosis2BeFree,GAD
umls:C0023895Liver diseases2BeFree
umls:C0024117Chronic Obstructive Airway Disease2BeFree
umls:C0026946Mycoses2BeFree
umls:C0027051Myocardial Infarction2BeFree,GAD
umls:C0027059Myocarditis2BeFree
umls:C0027819Neuroblastoma2BeFree
umls:C0027947Neutropenia2BeFree,GAD
umls:C0029463Osteosarcoma2BeFree,CTD_human,LHGDN
umls:C0030193Pain2BeFree
umls:C0032897Prader-Willi Syndrome2BeFree
umls:C0033860Psoriasis2BeFree
umls:C0034063Pulmonary Edema2BeFree
umls:C0037274Dermatologic disorders2BeFree
umls:C0151942Arterial thrombosis2BeFree
umls:C0152441Madelung Deformity2BeFree
umls:C0234251Inflammatory pain2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0266929Chronic Periodontitis2BeFree
umls:C0278883Metastatic melanoma2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0410445Osteomalacia secondary to drug2BeFree
umls:C0432230Langer Mesomelic Dysplasia Syndrome2BeFree
umls:C0524620Metabolic Syndrome X2BeFree,CTD_human
umls:C0566602Primary sclerosing cholangitis2BeFree
umls:C0585442Osteosarcoma of bone2BeFree
umls:C0598935Tumor Initiation2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0812413Malignant Pleural Mesothelioma2BeFree
umls:C0860204Cholestatic liver disease2BeFree
umls:C0860207Drug-Induced Liver Injury2CTD_human,GAD
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C1956346Coronary Artery Disease2BeFree
umls:C2607914Allergic rhinitis (disorder)2BeFree
umls:C0001144Acne Vulgaris1BeFree
umls:C0004763Barrett Esophagus1CTD_human
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0005956Bone Marrow Diseases1BeFree
umls:C0006840Candidiasis1BeFree
umls:C0006845Candidiasis, Chronic Mucocutaneous1BeFree
umls:C0007104Female Breast Carcinoma1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007682CNS disorder1BeFree
umls:C0008313Cholangitis, Sclerosing1BeFree,GAD
umls:C0008372Intrahepatic Cholestasis1LHGDN
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0010278Craniosynostosis1BeFree
umls:C0010674Cystic Fibrosis1BeFree
umls:C0011053Deafness1GAD
umls:C0011265Presenile dementia1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0011991Diarrhea1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0014170Endometrial Neoplasms1LHGDN
umls:C0014175Endometriosis1BeFree
umls:C0017178Gastrointestinal Diseases1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0018621Hay fever1BeFree
umls:C0018671Head and Neck Neoplasms1GAD
umls:C0018772Hearing Loss, Partial1GAD
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0019158Hepatitis1BeFree
umls:C0019209Hepatomegaly1CTD_human
umls:C0020542Pulmonary Hypertension1BeFree
umls:C0020676Hypothyroidism1BeFree
umls:C0021361Female infertility1CTD_human
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0022353Neonatal Jaundice1BeFree,CTD_human
umls:C0022548Keloid1BeFree
umls:C0023281Leishmaniasis1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0023530Leukopenia1BeFree,GAD
umls:C0024115Lung diseases1BeFree
umls:C0024131Lupus Vulgaris1BeFree
umls:C0024138Lupus Erythematosus, Discoid1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0025149Medulloblastoma1BeFree
umls:C0025500Mesothelioma1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0029456Osteoporosis1BeFree
umls:C0029458Osteoporosis, Postmenopausal1GAD
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0031269Peutz-Jeghers Syndrome1BeFree
umls:C0032962Pregnancy Complications1GAD
umls:C0033774Pruritus1BeFree
umls:C0033975Psychotic Disorders1BeFree
umls:C0034067Pulmonary Emphysema1BeFree
umls:C0035412Rhabdomyosarcoma1BeFree
umls:C0036572Seizures1BeFree
umls:C0036690Septicemia1BeFree
umls:C0037286Skin Neoplasms1BeFree
umls:C0037928Spinal Cord Diseases1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0042769Virus Diseases1BeFree
umls:C0085110Severe Combined Immunodeficiency1BeFree
umls:C0085183Neoplasms, Second Primary1GAD
umls:C0085278Antiphospholipid Syndrome1BeFree
umls:C0085409Polyendocrinopathies, Autoimmune1BeFree
umls:C0085682Hypophosphatemia1CTD_human
umls:C0149637Carcinoma of lip1BeFree
umls:C0151798Hepatic necrosis1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0152031Joint swelling1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0154251Lipid Metabolism Disorders1BeFree
umls:C0162810Cicatrix, Hypertrophic1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0235653Malignant neoplasm of female breast1BeFree
umls:C0242339Dyslipidemias1BeFree
umls:C0242852Proliferative vitreoretinopathy1BeFree
umls:C0243026Sepsis1BeFree
umls:C0265101Carotid artery occlusion1BeFree
umls:C0272302Gray Platelet Syndrome1BeFree
umls:C0276275Disease due to Parvoviridae1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0279702Conventional (Clear Cell) Renal Cell Carcinoma1BeFree
umls:C0282607Vascular Neoplasms1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0333186Restenosis1BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma1BeFree
umls:C0349204Nonorganic psychosis1BeFree
umls:C0375021Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0409974Lupus Erythematosus1BeFree
umls:C0432306Ichthyosis Bullosa of Siemens1BeFree
umls:C0497327Dementia1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0598766Leukemogenesis1BeFree
umls:C0600452Hepatopulmonary Syndrome1GAD
umls:C0699885Carcinoma of bladder1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0702166Acne1BeFree
umls:C0741899Poorly differentiated carcinoma1BeFree
umls:C0751214Hyperalgesia, Thermal1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0853897Diabetic Cardiomyopathies1BeFree
umls:C0856169Endothelial dysfunction1BeFree
umls:C0948780Rhinosinusitis1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1297882Partial Trisomy1BeFree
umls:C1318485Liver regeneration disorder1BeFree
umls:C1319853Asthma, Aspirin-Induced1BeFree
umls:C1333034Chronic Cancer Pain1BeFree
umls:C1336456Stage I Hepatocellular Carcinoma1BeFree
umls:C1368683Epithelioma1BeFree
umls:C1384666hearing impairment1GAD
umls:C1397307Cardiac fibrosis1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1519689Tumor Promotion1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C2608079WARFARIN SENSITIVITY (disorder)1GAD
umls:C2711227Steatohepatitis1BeFree
umls:C2936719Mechanical Allodynia1BeFree
umls:C2983423Stage III Hepatocellular Carcinoma1BeFree
umls:C3203102Idiopathic pulmonary arterial hypertension1BeFree
umls:C3887650Adult Rickets1LHGDN
umls:C3887873Hearing Loss1GAD