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| TissGeneSummary for PROZ |
 Gene summary |
| Basic gene information | Gene symbol | PROZ |
| Gene name | protein Z, vitamin K-dependent plasma glycoprotein | |
| Synonyms | PZ | |
| Cytomap | UCSC genome browser: 13q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256134.1, NM_003891.2, | |
| Description | vitamin K-dependent protein Z | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176895 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126231 | ||
| HPRD : 07182 | ||
| Vega : OTTHUMG00000017376 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PROZ | |
| BioGPS: 8858 | ||
| Pathway | NCI Pathway Interaction Database: PROZ | |
| KEGG: PROZ | ||
| REACTOME: PROZ | ||
| Pathway Commons: PROZ | ||
| Context | iHOP: PROZ | |
| ligand binding site mutation search in PubMed: PROZ | ||
| UCL Cancer Institute: PROZ | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of PROZ | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PROZ |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.082335165 | 2.78931796 | -4.871653125 | 5.37E-11 | 6.54E-10 |
| LIHC | 4.495441335 | 6.997389335 | -2.501948 | 5.85E-09 | 5.46E-08 |
| KIRC | -2.638947665 | 1.650288446 | -4.289236111 | 2.23E-19 | 1.65E-18 |
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| TissGene-miRNA for PROZ |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PROZ |
| TissGeneSNV for PROZ |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D309N | LUSC | 1 |
| p.E70* | UCEC | 1 |
| p.L7P | STAD | 1 |
| p.E77K | SKCM | 1 |
| p.R246S | HNSC | 1 |
| p.D169N | STAD | 1 |
| p.D206E | THYM | 1 |
| p.R339L | MESO | 1 |
| p.V5I | GBM | 1 |
| p.R203H | LGG | 1 |
| p.Q191_splice | UCEC | 1 |
| p.F72C | ACC | 1 |
| p.P183T | UCEC | 1 |
| p.W60L | CHOL | 1 |
| p.R224S | HNSC | 1 |
| p.R274L | LIHC | 1 |
| p.G221R | SKCM | 1 |
| p.G394V | ESCA | 1 |
| p.N233K | UCS | 1 |
| p.F388L | SARC | 1 |
| p.Q191H | UCEC | 1 |
| p.T390M | PAAD | 1 |
| p.N233H | PRAD | 1 |
| p.R84L | UCEC | 1 |
| p.T368M | PAAD | 1 |
| p.S335W | LUAD | 1 |
| p.E51K | LUSC | 1 |
| p.E132K | UCEC | 1 |
| p.W291* | SKCM | 1 |
| p.E51K | OV | 1 |
| p.R305H | UCEC | 1 |
| p.A276V | STAD | 1 |
| p.G130V | BLCA | 1 |
| p.L389I | BLCA | 1 |
| p.H381L | LUSC | 1 |
| p.D278N | PRAD | 1 |
| p.Q170K | LUSC | 1 |
| p.Q272* | BRCA | 1 |
| p.E66D | BRCA | 1 |
| p.Y109H | COAD | 1 |
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| TissGeneCNV for PROZ |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PROZ |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PROZ |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| COAD (tumor) | COAD (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| KICH (tumor) | KICH (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| STAD (tumor) | STAD (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| THCA (tumor) | THCA (normal) |
| PROZ, HNF4A, F2 (tumor) | PROZ, HNF4A, F2 (normal) |
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| TissGeneProg for PROZ |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PROZ |
| TissGeneDrug for PROZ |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00170 | Menadione | Activator | Small molecule | Approved|Nutraceutical |
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| TissGeneDisease for PROZ |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0038454 | Cerebrovascular accident | 5 | BeFree,GAD,LHGDN |
| umls:C0004943 | Behcet Syndrome | 2 | GAD,LHGDN |
| umls:C0042487 | Venous Thrombosis | 2 | GAD,LHGDN |
| umls:C0000809 | Abortion, Habitual | 1 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | LHGDN |
| umls:C0022116 | Ischemia | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | LHGDN |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0032914 | Pre-Eclampsia | 1 | LHGDN |
| umls:C0032962 | Pregnancy Complications | 1 | BeFree |
| umls:C0034186 | Pyelonephritis | 1 | LHGDN |
| umls:C0040038 | Thromboembolism | 1 | GAD |
| umls:C0040053 | Thrombosis | 1 | GAD |
| umls:C0398623 | Thrombophilia | 1 | GAD |
| umls:C0687675 | Pregnancy loss | 1 | GAD |
| umls:C0752143 | Intracranial Thrombosis | 1 | GAD |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 1 | GAD |
| umls:C0948089 | Acute Coronary Syndrome | 1 | LHGDN |
| umls:C1719672 | Severe Sepsis | 1 | GAD |
| umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 1 | GAD |
| umls:C3151465 | PROTEIN Z DEFICIENCY | 0 | CLINVAR |
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