TissGeneSummary for CACNA1I |
Gene summary |
Basic gene information | Gene symbol | CACNA1I |
Gene name | calcium channel, voltage-dependent, T type, alpha 1I subunit | |
Synonyms | Cav3.3|ca(v)3.3 | |
Cytomap | UCSC genome browser: 22q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001003406.1, NM_021096.3, | |
Description | calcium channel, voltage-dependent, alpha 1I subunitvoltage-dependent T-type calcium channel subunit alpha-1Ivoltage-gated calcium channel subunit alpha Cav3.3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608230 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100346 | ||
HPRD : 10500 | ||
Vega : OTTHUMG00000151096 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CACNA1I | |
BioGPS: 8911 | ||
Pathway | NCI Pathway Interaction Database: CACNA1I | |
KEGG: CACNA1I | ||
REACTOME: CACNA1I | ||
Pathway Commons: CACNA1I | ||
Context | iHOP: CACNA1I | |
ligand binding site mutation search in PubMed: CACNA1I | ||
UCL Cancer Institute: CACNA1I | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTHCA | |
Reference showing the relevant tissue of CACNA1I | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CACNA1I |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.687741785 | -4.242817785 | 2.555076 | 2.80E-05 | 8.16E-05 |
THCA | 2.552456655 | 3.754129537 | -1.201672881 | 3.94E-06 | 1.37E-05 |
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TissGene-miRNA for CACNA1I |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CACNA1I |
TissGeneSNV for CACNA1I |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G1782R | LGG | 2 |
p.S34F | SKCM | 2 |
p.G1434D | SKCM | 1 |
p.R1477Q | STAD | 1 |
p.S1353L | BLCA | 1 |
p.W231L | LUAD | 1 |
p.C1844Y | KIRC | 1 |
p.S1807C | PAAD | 1 |
p.Y834H | LUAD | 1 |
p.S1307F | SKCM | 1 |
p.F794L | HNSC | 1 |
p.N92K | COAD | 1 |
p.S835F | SKCM | 1 |
p.D828E | LUAD | 1 |
p.H1475Q | BRCA | 1 |
p.I1810T | STAD | 1 |
p.D714N | SKCM | 1 |
p.D805G | STAD | 1 |
p.S1833F | THYM | 1 |
p.G138W | HNSC | 1 |
p.G1782R | PRAD | 1 |
p.D302N | SKCM | 1 |
p.E1195A | CHOL | 1 |
p.P31L | LUSC | 1 |
p.E1522K | SKCM | 1 |
p.E1901K | BLCA | 1 |
p.Y373C | LUSC | 1 |
p.G899R | STAD | 1 |
p.I1040V | COAD | 1 |
p.P926L | SKCM | 1 |
p.E1895K | BLCA | 1 |
p.W319X | SKCM | 1 |
p.D302V | LUAD | 1 |
p.K787E | KIRP | 1 |
p.G1822R | SARC | 1 |
p.I1816T | STAD | 1 |
p.H1481Y | SKCM | 1 |
p.G44E | SKCM | 1 |
p.S949F | HNSC | 1 |
p.F123V | LUSC | 1 |
p.P68L | SKCM | 1 |
p.D822E | LUAD | 1 |
p.C1437S | STAD | 1 |
p.D299N | SKCM | 1 |
p.T179N | LUAD | 1 |
p.V1430M | UCEC | 1 |
p.R1453Q | HNSC | 1 |
p.R755Q | ESCA | 1 |
p.C1437R | STAD | 1 |
p.R1237H | PAAD | 1 |
p.V1279D | LUAD | 1 |
p.P1932L | SKCM | 1 |
p.S889F | SKCM | 1 |
p.H919Q | LUAD | 1 |
p.P1290L | STAD | 1 |
p.S955F | HNSC | 1 |
p.R749L | LUAD | 1 |
p.D103N | LGG | 1 |
p.R1275W | PAAD | 1 |
p.E1570K | SKCM | 1 |
p.C1443S | STAD | 1 |
p.R307G | LUAD | 1 |
p.I1255M | HNSC | 1 |
p.P284L | SKCM | 1 |
p.E1895K | SKCM | 1 |
p.F1835L | LUAD | 1 |
p.G1637V | HNSC | 1 |
p.L1985P | COAD | 1 |
p.R191C | SKCM | 1 |
p.D708N | READ | 1 |
p.D1958N | SKCM | 1 |
p.R1998W | UCEC | 1 |
p.P932L | SKCM | 1 |
p.L202F | SKCM | 1 |
p.I1200M | BLCA | 1 |
p.P1957Q | ESCA | 1 |
p.P515T | LUAD | 1 |
p.L1922V | LUSC | 1 |
p.S1839F | THYM | 1 |
p.R1663Q | ESCA | 1 |
p.W150L | LUAD | 1 |
p.R1449H | UCEC | 1 |
p.I338M | HNSC | 1 |
p.M1661I | SKCM | 1 |
p.V131L | UCEC | 1 |
p.R152H | STAD | 1 |
p.N311K | CESC | 1 |
p.L501F | CESC | 1 |
p.Q880X | SKCM | 1 |
p.Q289H | LUAD | 1 |
p.S1347L | BLCA | 1 |
p.V1242M | ESCA | 1 |
p.N339K | STAD | 1 |
p.V76M | SKCM | 1 |
p.G1665D | SKCM | 1 |
p.P2006T | LUAD | 1 |
p.R63* | PAAD | 1 |
p.S1301F | SKCM | 1 |
p.C280X | ESCA | 1 |
p.R69W | LUSC | 1 |
p.R418H | UCEC | 1 |
p.L920M | LGG | 1 |
p.A844T | STAD | 1 |
p.R1890C | SARC | 1 |
p.I1261M | HNSC | 1 |
p.R178H | COAD | 1 |
p.Y828H | LUAD | 1 |
p.L702F | HNSC | 1 |
p.V1541M | LUAD | 1 |
p.I1194M | BLCA | 1 |
p.A1352T | PAAD | 1 |
p.C93F | LUSC | 1 |
p.P1986S | LUSC | 1 |
p.R69Q | SKCM | 1 |
p.E1576K | SKCM | 1 |
p.W319* | SKCM | 1 |
p.T1218K | LIHC | 1 |
p.E899K | SKCM | 1 |
p.V762M | UCEC | 1 |
p.I1200M | CESC | 1 |
p.G138E | SKCM | 1 |
p.E1901K | SKCM | 1 |
p.F689V | LUAD | 1 |
p.L903F | COAD | 1 |
p.P1399L | SKCM | 1 |
p.D43N | BLCA | 1 |
p.C1341W | KIRP | 1 |
p.R1361H | CESC | 1 |
p.G502R | LGG | 1 |
p.G290C | LUAD | 1 |
p.S881N | STAD | 1 |
p.A232E | BLCA | 1 |
p.T1603I | BRCA | 1 |
p.S1353* | LUAD | 1 |
p.A871S | THYM | 1 |
p.G138R | LUSC | 1 |
p.R1904S | LUAD | 1 |
p.G358S | SKCM | 1 |
p.L214Q | LIHC | 1 |
p.I189M | LUAD | 1 |
p.D106N | SKCM | 1 |
p.A867V | STAD | 1 |
p.I1872M | LUAD | 1 |
p.G314C | PRAD | 1 |
p.F788L | HNSC | 1 |
p.T1212K | LIHC | 1 |
p.A1358T | PAAD | 1 |
p.G899R | COAD | 1 |
p.G1782R | STAD | 1 |
p.R1467H | ACC | 1 |
p.H1487Y | SKCM | 1 |
p.P35L | ACC | 1 |
p.K1978N | LUSC | 1 |
p.A17T | SKCM | 1 |
p.R463Q | LIHC | 1 |
p.S1006L | LUAD | 1 |
p.R1904L | LUAD | 1 |
p.R238H | READ | 1 |
p.P919S | SKCM | 1 |
p.E1896K | HNSC | 1 |
p.V1256A | UCEC | 1 |
p.V180M | STAD | 1 |
p.R965H | STAD | 1 |
p.L2003V | BLCA | 1 |
p.D1694N | STAD | 1 |
p.P333R | LUAD | 1 |
p.V831I | SARC | 1 |
p.A1262D | ESCA | 1 |
p.N1931S | SKCM | 1 |
p.P2006L | SKCM | 1 |
p.R504Q | STAD | 1 |
p.R749Q | ESCA | 1 |
p.E1963* | GBM | 1 |
p.D1850N | SKCM | 1 |
p.E1569K | SKCM | 1 |
p.A337D | COAD | 1 |
p.R1438Q | COAD | 1 |
p.E1662K | STAD | 1 |
p.T1482I | LGG | 1 |
p.R737H | KIRC | 1 |
p.L1614P | LUAD | 1 |
p.R1657Q | ESCA | 1 |
p.D704H | BLCA | 1 |
p.E893K | SKCM | 1 |
p.R1998Q | COAD | 1 |
p.F1971S | HNSC | 1 |
p.N1937S | SKCM | 1 |
p.E1821K | SKCM | 1 |
p.Q886* | SKCM | 1 |
p.R1461P | LUAD | 1 |
p.D622N | SKCM | 1 |
p.P1938L | SKCM | 1 |
p.R1207H | LUAD | 1 |
p.S1999F | SKCM | 1 |
p.R627W | UCEC | 1 |
p.A55V | GBM | 1 |
p.P2000L | SKCM | 1 |
p.S1239I | PAAD | 1 |
p.R1243H | PAAD | 1 |
p.V1619M | SKCM | 1 |
p.P925S | SKCM | 1 |
p.A1953T | LIHC | 1 |
p.F842L | STAD | 1 |
p.S67N | SKCM | 1 |
p.P41T | STAD | 1 |
p.M412T | HNSC | 1 |
p.K740N | STAD | 1 |
p.D760N | SKCM | 1 |
p.V1914I | GBM | 1 |
p.E1649K | LUSC | 1 |
p.P1290Q | LUSC | 1 |
p.H409Y | PAAD | 1 |
p.S1819F | SKCM | 1 |
p.E1201A | CHOL | 1 |
p.G1648E | SKCM | 1 |
p.N92D | LIHC | 1 |
p.V2010I | SKCM | 1 |
p.T1527N | STAD | 1 |
p.S371F | SKCM | 1 |
p.M1752I | SKCM | 1 |
p.P79S | SKCM | 1 |
p.T328M | STAD | 1 |
p.G1643V | HNSC | 1 |
p.C1335W | KIRP | 1 |
p.I1821T | HNSC | 1 |
p.R1468Q | LGG | 1 |
p.G612E | SKCM | 1 |
p.T770N | LUAD | 1 |
p.F1328L | LUSC | 1 |
p.Y165H | UCS | 1 |
p.G1263R | PAAD | 1 |
p.D766N | SKCM | 1 |
p.S1257F | CESC | 1 |
p.E1149K | BLCA | 1 |
p.V1248M | ESCA | 1 |
p.S812F | SKCM | 1 |
p.K1649Q | SKCM | 1 |
p.S841F | SKCM | 1 |
p.R879C | SKCM | 1 |
p.D708N | SKCM | 1 |
p.L1538R | COAD | 1 |
p.K1978R | KIRP | 1 |
p.F713L | LUAD | 1 |
p.S1245I | PAAD | 1 |
p.E288K | OV | 1 |
p.M1672I | HNSC | 1 |
p.E1575K | SKCM | 1 |
p.P2013S | HNSC | 1 |
p.R941* | SKCM | 1 |
p.R731Q | COAD | 1 |
p.G1269R | PAAD | 1 |
p.G495E | SKCM | 1 |
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TissGeneCNV for CACNA1I |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CACNA1I |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG995152 | CACNA1I-ZNF462 | chr22:40085201 | chr9:109677900 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JM-01A | CACNA1I-TAB1 | In-frame | Chr22:40058440 | Chr22:39822708 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-6941-01A | SH3BP1-CACNA1I | In-frame | Chr22:38039795 | Chr22:40057970 |
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TissGeneNet for CACNA1I |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CACNA1I |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CACNA1I |
TissGeneDrug for CACNA1I |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00617 | Paramethadione | Suppressor | Small molecule | Approved |
DB00661 | Verapamil | Inhibitor | Small molecule | Approved |
DB04841 | Flunarizine | Inhibitor | Small molecule | Approved |
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TissGeneDisease for CACNA1I |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |