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| TissGeneSummary for CDK5R2 |
 Gene summary |
| Basic gene information | Gene symbol | CDK5R2 |
| Gene name | cyclin-dependent kinase 5, regulatory subunit 2 (p39) | |
| Synonyms | NCK5AI|P39|p39nck5ai | |
| Cytomap | UCSC genome browser: 2q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003936.4, | |
| Description | CDK5 activator 2cyclin-dependent kinase 5 activator 2cyclin-dependent kinase 5 activator isoform p39icyclin-dependent kinase 5 regulatory subunit 2neuronal CDK5 activator isoformp39I | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603764 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171450 | ||
| HPRD : 04790 | ||
| Vega : OTTHUMG00000133083 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDK5R2 | |
| BioGPS: 8941 | ||
| Pathway | NCI Pathway Interaction Database: CDK5R2 | |
| KEGG: CDK5R2 | ||
| REACTOME: CDK5R2 | ||
| Pathway Commons: CDK5R2 | ||
| Context | iHOP: CDK5R2 | |
| ligand binding site mutation search in PubMed: CDK5R2 | ||
| UCL Cancer Institute: CDK5R2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
| Reference showing the relevant tissue of CDK5R2 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CDK5R2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -1.381331388 | -2.905937638 | 1.52460625 | 1.81E-05 | 7.20E-05 |
| LUSC | -0.818890641 | -2.889943582 | 2.071052941 | 6.77E-12 | 2.88E-11 |
| COAD | -1.33789509 | 0.915974141 | -2.253869231 | 2.02E-09 | 2.08E-08 |
| LUAD | -0.278084082 | -2.629075462 | 2.350991379 | 2.70E-11 | 1.77E-10 |
| HNSC | -1.710663874 | -2.808784804 | 1.09812093 | 6.99E-05 | 0.000327656 |
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| TissGene-miRNA for CDK5R2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-96-5p | MIMAT0000095 | 0.0026 | -0.35 | 80 |
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| TissGeneMut for CDK5R2 |
| TissGeneSNV for CDK5R2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G91D | STAD | 1 |
| p.E257K | STAD | 1 |
| p.E276K | SKCM | 1 |
| p.A350S | READ | 1 |
| p.R296L | OV | 1 |
| p.T232K | BLCA | 1 |
| p.P111S | SKCM | 1 |
| p.R197H | STAD | 1 |
| p.R200H | STAD | 1 |
| p.A255D | LUAD | 1 |
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| TissGeneCNV for CDK5R2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDK5R2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF957903 | CDK5R2-CRAMP1L | chr2:219826231 | chr16:1671384 |
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| TissGeneNet for CDK5R2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (tumor) | CDK5R2, CAMK2A, ACTB, CDK5, ACTN1, CHN1 (normal) |
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| Top |
| TissGeneProg for CDK5R2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CDK5R2 |
| TissGeneDrug for CDK5R2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDK5R2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024198 | Lyme Disease | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | LHGDN |
| umls:C0006111 | Brain Diseases | 1 | BeFree |
| umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
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