TissGeneSummary for KYNU |
Gene summary |
Basic gene information | Gene symbol | KYNU |
Gene name | kynureninase | |
Synonyms | KYNUU | |
Cytomap | UCSC genome browser: 2q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001032998.1, NM_001199241.1,NM_003937.2, | |
Description | L-kynurenine hydrolase | |
Modification date | 20141207 | |
dbXrefs | MIM : 605197 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115919 | ||
HPRD : 08940 | ||
Vega : OTTHUMG00000131829 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KYNU | |
BioGPS: 8942 | ||
Pathway | NCI Pathway Interaction Database: KYNU | |
KEGG: KYNU | ||
REACTOME: KYNU | ||
Pathway Commons: KYNU | ||
Context | iHOP: KYNU | |
ligand binding site mutation search in PubMed: KYNU | ||
UCL Cancer Institute: KYNU | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLIHC | |
Reference showing the relevant tissue of KYNU | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0019805 | quinolinate biosynthetic process | 9291104 | GO:0034341 | response to interferon-gamma | 9291104 | GO:0043420 | anthranilate metabolic process | 11985583 | GO:0019805 | quinolinate biosynthetic process | 9291104 | GO:0034341 | response to interferon-gamma | 9291104 | GO:0043420 | anthranilate metabolic process | 11985583 |
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TissGeneExp for KYNU |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 1.729792646 | 3.302262646 | -1.57247 | 6.39E-06 | 2.83E-05 |
ESCA | 0.301357737 | -2.505296808 | 2.806654545 | 0.00212 | 0.02334099 |
HNSC | 1.638332367 | 0.093271902 | 1.545060465 | 6.88E-05 | 0.000323849 |
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TissGene-miRNA for KYNU |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KYNU |
TissGeneSNV for KYNU |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P166S | SKCM | 2 |
p.G73E | SKCM | 2 |
p.R155Q | SKCM | 2 |
p.H32P | SKCM | 1 |
p.K384N | UCEC | 1 |
p.E197Q | LUAD | 1 |
p.R358Q | READ | 1 |
p.E130X | READ | 1 |
p.L368V | LUAD | 1 |
p.W265* | STAD | 1 |
p.D250Y | HNSC | 1 |
p.I110N | UCEC | 1 |
p.G266R | SKCM | 1 |
p.P108H | PAAD | 1 |
p.D426Y | LUAD | 1 |
p.K412E | COAD | 1 |
p.E206K | SKCM | 1 |
p.E90K | COAD | 1 |
p.D459N | SKCM | 1 |
p.R188W | PCPG | 1 |
p.P234L | LIHC | 1 |
p.S75Y | READ | 1 |
p.K157N | UCEC | 1 |
p.N127S | LUAD | 1 |
p.W109X | SKCM | 1 |
p.M120L | LUSC | 1 |
p.H253N | SARC | 1 |
p.G244D | SKCM | 1 |
p.C425R | LIHC | 1 |
p.G180E | SKCM | 1 |
p.W265* | LUAD | 1 |
p.N182Y | LUAD | 1 |
p.R155* | LUAD | 1 |
p.F305L | BRCA | 1 |
p.V435L | ESCA | 1 |
p.A136S | PRAD | 1 |
p.E66Q | HNSC | 1 |
p.M134I | READ | 1 |
p.E89K | STAD | 1 |
p.S75Y | STAD | 1 |
p.A126T | SKCM | 1 |
p.R330Q | SARC | 1 |
p.G304E | SKCM | 1 |
p.T406P | SKCM | 1 |
p.A30S | LUAD | 1 |
p.H142Q | MESO | 1 |
p.R330X | PRAD | 1 |
p.L199S | HNSC | 1 |
p.V217M | STAD | 1 |
p.H169Y | SKCM | 1 |
p.N465K | COAD | 1 |
p.S408F | UCS | 1 |
p.R330* | PRAD | 1 |
p.K150R | KICH | 1 |
p.I204M | KIRP | 1 |
p.L251Q | BLCA | 1 |
p.E36K | SKCM | 1 |
p.P166H | GBM | 1 |
p.E35K | HNSC | 1 |
p.D250H | OV | 1 |
p.G287D | LUAD | 1 |
p.V414A | UCEC | 1 |
p.Y441H | KIRC | 1 |
p.S221I | LUAD | 1 |
p.R428G | CHOL | 1 |
p.R358Q | SKCM | 1 |
p.V223A | KICH | 1 |
p.A352V | UCS | 1 |
p.R434* | SKCM | 1 |
p.W109* | SKCM | 1 |
p.C45R | UCEC | 1 |
p.R188W | THYM | 1 |
p.K64E | KIRC | 1 |
p.E128D | UCEC | 1 |
p.G328* | LUAD | 1 |
p.W265X | STAD | 1 |
p.C271S | LUAD | 1 |
p.S75C | ESCA | 1 |
p.I208N | STAD | 1 |
p.A126G | HNSC | 1 |
p.E7Q | LUAD | 1 |
p.D122E | LUAD | 1 |
p.Q14K | LUSC | 1 |
p.T152M | PRAD | 1 |
p.G432V | SARC | 1 |
p.G328E | LUAD | 1 |
p.R399Q | HNSC | 1 |
p.S443F | SKCM | 1 |
p.Y448H | HNSC | 1 |
p.C273F | LUAD | 1 |
p.P334L | SKCM | 1 |
p.W109C | LUAD | 1 |
p.M316I | LUSC | 1 |
p.L159F | SKCM | 1 |
p.H308Y | SKCM | 1 |
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TissGeneCNV for KYNU |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KYNU |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP333200 | HTN1-KYNU | chr4:70924377 | chr2:143795116 | |
Chimerdb3.0 | ChiTaRs | NA | BF997792 | TGOLN2-KYNU | chr2:85548146 | chr2:143725826 | |
Chimerdb3.0 | ChiTaRs | NA | BF907726 | KYNU-KYNU | chr2:143743591 | chr2:143712379 | |
Chimerdb3.0 | ChiTaRs | NA | CB851853 | KYNU-KYNU | chr2:143747106 | chr2:143746729 | |
Chimerdb3.0 | FusionScan | LGG | TCGA-HT-7477-01B | PBRM1-KYNU | In-Frame | chr3:52692214 | chr2:143742652 |
TCGAfusionPortal | PRADA | LGG | TCGA-HT-7477-01B | PBRM1-KYNU | In-frame | Chr3:52692215 | Chr2:143742653 |
TCGAfusionPortal | PRADA | LUAD | TCGA-38-4630-01A | ARHGAP15-KYNU | In-frame | Chr2:144008169 | Chr2:143742653 |
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TissGeneNet for KYNU |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KYNU |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KYNU |
TissGeneDrug for KYNU |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KYNU |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0021368 | Inflammation | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085580 | Essential Hypertension | 1 | BeFree |
umls:C0268474 | Hydroxykynureninuria | 1 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0524851 | Neurodegenerative Disorders | 1 | CTD_human |