TissGeneSummary for GAL3ST3 |
Gene summary |
Basic gene information | Gene symbol | GAL3ST3 |
Gene name | galactose-3-O-sulfotransferase 3 | |
Synonyms | GAL3ST-3|GAL3ST2 | |
Cytomap | UCSC genome browser: 11q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_033036.2, | |
Description | beta-galactose-3-O-sulfotransferase 3gal-beta-1, 3-GalNAc 3'-sulfotransferase 3galactose 3'-sulfotransferasegalbeta1-3GalNAc 3'-sulfotransferase 3 | |
Modification date | 20141217 | |
dbXrefs | MIM : 608234 | |
HGNC : HGNC | ||
HPRD : 10501 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GAL3ST3 | |
BioGPS: 89792 | ||
Pathway | NCI Pathway Interaction Database: GAL3ST3 | |
KEGG: GAL3ST3 | ||
REACTOME: GAL3ST3 | ||
Pathway Commons: GAL3ST3 | ||
Context | iHOP: GAL3ST3 | |
ligand binding site mutation search in PubMed: GAL3ST3 | ||
UCL Cancer Institute: GAL3ST3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid glandEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCAUVM | |
Reference showing the relevant tissue of GAL3ST3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for GAL3ST3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.635378855 | 3.545411423 | -5.180790278 | 1.59E-40 | 6.72E-39 |
KIRP | -0.184923994 | 3.968516631 | -4.153440625 | 2.60E-10 | 2.78E-09 |
KICH | -2.111913244 | 4.377142756 | -6.489056 | 6.88E-24 | 1.08E-21 |
PRAD | -0.007020628 | 1.110896679 | -1.117917308 | 2.75E-05 | 0.000133973 |
Top |
TissGene-miRNA for GAL3ST3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for GAL3ST3 |
TissGeneSNV for GAL3ST3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A221D | COAD | 3 |
p.R215H | STAD | 2 |
p.E410A | THCA | 2 |
p.A221D | DLBC | 2 |
p.R152H | UCS | 1 |
p.R89C | PAAD | 1 |
p.A193T | OV | 1 |
p.E232K | SKCM | 1 |
p.P99S | SKCM | 1 |
p.V125M | STAD | 1 |
p.R270H | STAD | 1 |
p.D220N | STAD | 1 |
p.A186V | MESO | 1 |
p.D220E | LUAD | 1 |
p.D220G | STAD | 1 |
p.R185C | HNSC | 1 |
p.A178T | BLCA | 1 |
p.A87V | SKCM | 1 |
p.R229C | STAD | 1 |
p.E188K | SKCM | 1 |
p.V175I | KIRP | 1 |
p.P280S | SKCM | 1 |
p.P108H | PRAD | 1 |
p.E246D | LUAD | 1 |
p.A281T | PAAD | 1 |
p.H90D | BLCA | 1 |
p.P58Q | LUAD | 1 |
p.P280A | KIRP | 1 |
p.R192H | BLCA | 1 |
p.S57L | SKCM | 1 |
p.D220S | STAD | 1 |
p.R253H | STAD | 1 |
p.E159X | LIHC | 1 |
p.S50R | KICH | 1 |
p.V262M | STAD | 1 |
p.A11D | LUSC | 1 |
p.R55W | STAD | 1 |
p.L49F | LUSC | 1 |
p.R109H | UCEC | 1 |
p.T74M | COAD | 1 |
p.A193T | COAD | 1 |
p.C51G | KICH | 1 |
p.E88D | LUAD | 1 |
p.A269G | LUAD | 1 |
p.E195G | BLCA | 1 |
p.R218H | CESC | 1 |
p.A221D | READ | 1 |
p.D245N | LGG | 1 |
p.P142L | STAD | 1 |
p.D260A | LUAD | 1 |
p.R252W | LUSC | 1 |
p.E102X | COAD | 1 |
p.P187T | LUAD | 1 |
p.A282V | STAD | 1 |
p.A186V | STAD | 1 |
p.E214Q | HNSC | 1 |
p.A265V | LIHC | 1 |
p.R60H | LUAD | 1 |
p.A171V | SKCM | 1 |
p.V125M | PRAD | 1 |
p.E159* | LIHC | 1 |
Top |
TissGeneCNV for GAL3ST3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for GAL3ST3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for GAL3ST3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for GAL3ST3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for GAL3ST3 |
TissGeneDrug for GAL3ST3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for GAL3ST3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |