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| TissGeneSummary for SEC16B |
 Gene summary |
| Basic gene information | Gene symbol | SEC16B |
| Gene name | SEC16 homolog B (S. cerevisiae) | |
| Synonyms | LZTR2|PGPR-p117|RGPR|SEC16S | |
| Cytomap | UCSC genome browser: 1q25.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_033127.2, | |
| Description | RGPR-p117leucine zipper transcription regulator 2protein SEC16 homolog Bprotein transport protein Sec16Bregucalcin gene promoter region-related protein p117regucalcin gene promotor region related protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612855 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120341 | ||
| HPRD : 11491 | ||
| Vega : OTTHUMG00000167206 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SEC16B | |
| BioGPS: 89866 | ||
| Pathway | NCI Pathway Interaction Database: SEC16B | |
| KEGG: SEC16B | ||
| REACTOME: SEC16B | ||
| Pathway Commons: SEC16B | ||
| Context | iHOP: SEC16B | |
| ligand binding site mutation search in PubMed: SEC16B | ||
| UCL Cancer Institute: SEC16B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SEC16B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007029 | endoplasmic reticulum organization | 21768384 | GO:0007031 | peroxisome organization | 21768384 | GO:0070972 | protein localization to endoplasmic reticulum | 21768384 | GO:0007029 | endoplasmic reticulum organization | 21768384 | GO:0007031 | peroxisome organization | 21768384 | GO:0070972 | protein localization to endoplasmic reticulum | 21768384 |
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| TissGeneExp for SEC16B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.061423913 | 1.00100328 | -1.062427193 | 6.99E-19 | 4.58E-18 |
| KIRC | 1.791888221 | 0.608025721 | 1.1838625 | 3.43E-17 | 2.07E-16 |
| KICH | -0.785247001 | 1.145448999 | -1.930696 | 4.77E-07 | 1.89E-06 |
| HNSC | 0.333171231 | -0.788224117 | 1.121395349 | 5.12E-05 | 0.000246154 |
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| TissGene-miRNA for SEC16B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SEC16B |
| TissGeneSNV for SEC16B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P6S | SKCM | 2 |
| p.H279D | PAAD | 2 |
| p.L632F | SKCM | 1 |
| p.P278S | SKCM | 1 |
| p.H720Y | BLCA | 1 |
| p.P1032S | SKCM | 1 |
| p.D741Y | LUAD | 1 |
| p.R94S | HNSC | 1 |
| p.P968L | OV | 1 |
| p.G519A | OV | 1 |
| p.Q605H | HNSC | 1 |
| p.R1046W | SKCM | 1 |
| p.P252S | SKCM | 1 |
| p.E651K | UCEC | 1 |
| p.Y783C | BLCA | 1 |
| p.W914* | SKCM | 1 |
| p.M569T | SKCM | 1 |
| p.V280G | KIRC | 1 |
| p.D741N | BLCA | 1 |
| p.G31E | STAD | 1 |
| p.G523A | BRCA | 1 |
| p.E825G | LIHC | 1 |
| p.R25Q | LUSC | 1 |
| p.R227H | LGG | 1 |
| p.P891L | SKCM | 1 |
| p.S800P | KIRC | 1 |
| p.R1054C | BRCA | 1 |
| p.A926T | SARC | 1 |
| p.H127D | LUAD | 1 |
| p.P168R | LUAD | 1 |
| p.A676V | PRAD | 1 |
| p.A546V | UCEC | 1 |
| p.V36L | HNSC | 1 |
| p.H279D | STAD | 1 |
| p.L1017R | SKCM | 1 |
| p.S229F | PAAD | 1 |
| p.D335N | SKCM | 1 |
| p.S663I | LGG | 1 |
| p.M827L | SKCM | 1 |
| p.P251S | SKCM | 1 |
| p.P168A | PAAD | 1 |
| p.H71N | GBM | 1 |
| p.G955C | LUAD | 1 |
| p.Q261H | LUAD | 1 |
| p.G31R | GBM | 1 |
| p.L806V | BLCA | 1 |
| p.S39C | BLCA | 1 |
| p.R690H | UCEC | 1 |
| p.R227H | UCEC | 1 |
| p.E196K | LUAD | 1 |
| p.K877R | LUSC | 1 |
| p.V643M | BRCA | 1 |
| p.E319K | LGG | 1 |
| p.E319D | UCEC | 1 |
| p.D788Y | UCEC | 1 |
| p.P802S | CESC | 1 |
| p.S318Y | BRCA | 1 |
| p.R690H | LGG | 1 |
| p.P404S | SKCM | 1 |
| p.S920L | LUAD | 1 |
| p.I385V | COAD | 1 |
| p.S724L | HNSC | 1 |
| p.P278S | SARC | 1 |
| p.D340N | HNSC | 1 |
| p.R893L | LUSC | 1 |
| p.E228* | HNSC | 1 |
| p.R892Q | ESCA | 1 |
| p.R63M | BLCA | 1 |
| p.R8M | UCEC | 1 |
| p.P37S | SKCM | 1 |
| p.I853F | ESCA | 1 |
| p.R248W | LUAD | 1 |
| p.E149K | UCEC | 1 |
| p.G754W | LUSC | 1 |
| p.G378E | SKCM | 1 |
| p.H279D | KIRC | 1 |
| p.S957* | HNSC | 1 |
| p.G378W | SKCM | 1 |
| p.Y399F | PRAD | 1 |
| p.P295S | BRCA | 1 |
| p.D78N | LUAD | 1 |
| p.P281H | UCEC | 1 |
| p.R690H | LUAD | 1 |
| p.S310I | UCEC | 1 |
| p.S283N | PRAD | 1 |
| p.P251L | SKCM | 1 |
| p.T578I | SKCM | 1 |
| p.S866N | LIHC | 1 |
| p.A638S | ESCA | 1 |
| p.V643M | LUAD | 1 |
| p.V572M | HNSC | 1 |
| p.A386T | BLCA | 1 |
| p.H279R | KIRC | 1 |
| p.I432T | UCEC | 1 |
| p.A350D | PCPG | 1 |
| p.S1012Y | BLCA | 1 |
| p.Q351E | HNSC | 1 |
| p.E320D | UCEC | 1 |
| p.R705Q | STAD | 1 |
| p.K43T | UCEC | 1 |
| p.L968V | OV | 1 |
| p.E709K | KIRC | 1 |
| p.T601A | LUSC | 1 |
| p.G661E | SKCM | 1 |
| p.A929D | SARC | 1 |
| p.F202L | DLBC | 1 |
| p.R152Q | UCEC | 1 |
| p.G641S | LUAD | 1 |
| p.Q774K | READ | 1 |
| p.S383F | SKCM | 1 |
| p.P923T | KIRP | 1 |
| p.P846L | ESCA | 1 |
| p.G731E | SKCM | 1 |
| p.R1054H | LGG | 1 |
| p.E651K | BLCA | 1 |
| p.V839A | UCEC | 1 |
| p.R28W | SKCM | 1 |
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| TissGeneCNV for SEC16B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SEC16B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BX494775 | SEC16B-SEC16B | chr1:177906406 | chr1:177911068 |
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| TissGeneNet for SEC16B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| COAD (tumor) | COAD (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| KICH (tumor) | KICH (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| STAD (tumor) | STAD (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| THCA (tumor) | THCA (normal) |
| SEC16B, SEC13 (tumor) | SEC16B, SEC13 (normal) |
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| TissGeneProg for SEC16B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SEC16B |
| TissGeneDrug for SEC16B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SEC16B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 13 | BeFree,GAD |
| umls:C0005910 | Body Weight | 2 | CTD_human |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0035304 | Retinal Degeneration | 1 | BeFree |
| umls:C1848172 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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