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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SEC16B
check button Gene summary
Basic gene informationGene symbolSEC16B
Gene nameSEC16 homolog B (S. cerevisiae)
SynonymsLZTR2|PGPR-p117|RGPR|SEC16S
CytomapUCSC genome browser: 1q25.2
Type of geneprotein-coding
RefGenesNM_033127.2,
DescriptionRGPR-p117leucine zipper transcription regulator 2protein SEC16 homolog Bprotein transport protein Sec16Bregucalcin gene promoter region-related protein p117regucalcin gene promotor region related protein
Modification date20141207
dbXrefs MIM : 612855
HGNC : HGNC
Ensembl : ENSG00000120341
HPRD : 11491
Vega : OTTHUMG00000167206
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SEC16B
BioGPS: 89866
PathwayNCI Pathway Interaction Database: SEC16B
KEGG: SEC16B
REACTOME: SEC16B
Pathway Commons: SEC16B
ContextiHOP: SEC16B
ligand binding site mutation search in PubMed: SEC16B
UCL Cancer Institute: SEC16B
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of SEC16B
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007029endoplasmic reticulum organization21768384
GO:0007031peroxisome organization21768384
GO:0070972protein localization to endoplasmic reticulum21768384
GO:0007029endoplasmic reticulum organization21768384
GO:0007031peroxisome organization21768384
GO:0070972protein localization to endoplasmic reticulum21768384


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TissGeneExp for SEC16B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA-0.0614239131.00100328-1.0624271936.99E-194.58E-18
KIRC1.7918882210.6080257211.18386253.43E-172.07E-16
KICH-0.7852470011.145448999-1.9306964.77E-071.89E-06
HNSC0.333171231-0.7882241171.1213953495.12E-050.000246154


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TissGene-miRNA for SEC16B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SEC16B
TissGeneSNV for SEC16B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P6SSKCM2
p.H279DPAAD2
p.L632FSKCM1
p.P278SSKCM1
p.H720YBLCA1
p.P1032SSKCM1
p.D741YLUAD1
p.R94SHNSC1
p.P968LOV1
p.G519AOV1
p.Q605HHNSC1
p.R1046WSKCM1
p.P252SSKCM1
p.E651KUCEC1
p.Y783CBLCA1
p.W914*SKCM1
p.M569TSKCM1
p.V280GKIRC1
p.D741NBLCA1
p.G31ESTAD1
p.G523ABRCA1
p.E825GLIHC1
p.R25QLUSC1
p.R227HLGG1
p.P891LSKCM1
p.S800PKIRC1
p.R1054CBRCA1
p.A926TSARC1
p.H127DLUAD1
p.P168RLUAD1
p.A676VPRAD1
p.A546VUCEC1
p.V36LHNSC1
p.H279DSTAD1
p.L1017RSKCM1
p.S229FPAAD1
p.D335NSKCM1
p.S663ILGG1
p.M827LSKCM1
p.P251SSKCM1
p.P168APAAD1
p.H71NGBM1
p.G955CLUAD1
p.Q261HLUAD1
p.G31RGBM1
p.L806VBLCA1
p.S39CBLCA1
p.R690HUCEC1
p.R227HUCEC1
p.E196KLUAD1
p.K877RLUSC1
p.V643MBRCA1
p.E319KLGG1
p.E319DUCEC1
p.D788YUCEC1
p.P802SCESC1
p.S318YBRCA1
p.R690HLGG1
p.P404SSKCM1
p.S920LLUAD1
p.I385VCOAD1
p.S724LHNSC1
p.P278SSARC1
p.D340NHNSC1
p.R893LLUSC1
p.E228*HNSC1
p.R892QESCA1
p.R63MBLCA1
p.R8MUCEC1
p.P37SSKCM1
p.I853FESCA1
p.R248WLUAD1
p.E149KUCEC1
p.G754WLUSC1
p.G378ESKCM1
p.H279DKIRC1
p.S957*HNSC1
p.G378WSKCM1
p.Y399FPRAD1
p.P295SBRCA1
p.D78NLUAD1
p.P281HUCEC1
p.R690HLUAD1
p.S310IUCEC1
p.S283NPRAD1
p.P251LSKCM1
p.T578ISKCM1
p.S866NLIHC1
p.A638SESCA1
p.V643MLUAD1
p.V572MHNSC1
p.A386TBLCA1
p.H279RKIRC1
p.I432TUCEC1
p.A350DPCPG1
p.S1012YBLCA1
p.Q351EHNSC1
p.E320DUCEC1
p.R705QSTAD1
p.K43TUCEC1
p.L968VOV1
p.E709KKIRC1
p.T601ALUSC1
p.G661ESKCM1
p.A929DSARC1
p.F202LDLBC1
p.R152QUCEC1
p.G641SLUAD1
p.Q774KREAD1
p.S383FSKCM1
p.P923TKIRP1
p.P846LESCA1
p.G731ESKCM1
p.R1054HLGG1
p.E651KBLCA1
p.V839AUCEC1
p.R28WSKCM1


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TissGeneCNV for SEC16B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SEC16B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABX494775SEC16B-SEC16Bchr1:177906406chr1:177911068


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TissGeneNet for SEC16B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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COAD (tumor)COAD (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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HNSC (tumor)HNSC (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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KICH (tumor)KICH (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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KIRC (tumor)KIRC (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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KIRP (tumor)KIRP (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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LIHC (tumor)LIHC (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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LUAD (tumor)LUAD (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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LUSC (tumor)LUSC (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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PRAD (tumor)PRAD (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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STAD (tumor)STAD (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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THCA (tumor)THCA (normal)
SEC16B, SEC13 (tumor)SEC16B, SEC13 (normal)
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TissGeneProg for SEC16B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SEC16B
TissGeneDrug for SEC16B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SEC16B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0028754Obesity13BeFree,GAD
umls:C0005910Body Weight2CTD_human
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2GAD
umls:C0004096Asthma1GAD
umls:C0023903Liver neoplasms1BeFree
umls:C0035304Retinal Degeneration1BeFree
umls:C1848172NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A1BeFree
umls:C2239176Liver carcinoma1BeFree