TissGeneSummary for PLCZ1 |
Gene summary |
Basic gene information | Gene symbol | PLCZ1 |
Gene name | phospholipase C, zeta 1 | |
Synonyms | NYD-SP27|PLC-zeta-1|PLCzeta | |
Cytomap | UCSC genome browser: 12p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_033123.3, NR_073075.1, | |
Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1PI-phospholipase C zeta 1PLC-zeta-1phosphoinositide phospholipase C-zeta-1testis-development related NYD-SP27 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608075 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139151 | ||
HPRD : 06996 | ||
Vega : OTTHUMG00000168937 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PLCZ1 | |
BioGPS: 89869 | ||
Pathway | NCI Pathway Interaction Database: PLCZ1 | |
KEGG: PLCZ1 | ||
REACTOME: PLCZ1 | ||
Pathway Commons: PLCZ1 | ||
Context | iHOP: PLCZ1 | |
ligand binding site mutation search in PubMed: PLCZ1 | ||
UCL Cancer Institute: PLCZ1 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PLCZ1 | Testis-specific novel transcripts in chicken: in situ localization and expression pattern profiling during sexual development. Rengaraj D, Kim DK, Zheng YH, Lee SI, Kim H, Han JY. Biol Reprod. 2008 Sep;79(3):413-20. doi: 10.1095/biolreprod.108.067959. Epub 2008 Apr 30 (pmid:18448841) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PLCZ1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.502770799 | -0.497735711 | -1.005035088 | 1.50E-24 | 1.44E-23 |
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TissGene-miRNA for PLCZ1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PLCZ1 |
TissGeneSNV for PLCZ1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G302E | SKCM | 3 |
p.E304K | SKCM | 2 |
p.G300E | SKCM | 2 |
p.G99E | SKCM | 2 |
p.R63Q | SKCM | 2 |
p.H396Y | SKCM | 2 |
p.G317E | SKCM | 2 |
p.E119K | SKCM | 2 |
p.S378Y | READ | 2 |
p.G17E | SKCM | 2 |
p.R584H | COAD | 2 |
p.G556S | SKCM | 1 |
p.D137E | ESCA | 1 |
p.K334N | BLCA | 1 |
p.K9N | UCEC | 1 |
p.L31I | PRAD | 1 |
p.G558S | SKCM | 1 |
p.L343I | SARC | 1 |
p.L248F | LUAD | 1 |
p.R316C | COAD | 1 |
p.S453F | STAD | 1 |
p.E564K | SKCM | 1 |
p.Q265* | PRAD | 1 |
p.G269* | LUAD | 1 |
p.E72K | SKCM | 1 |
p.V607I | CESC | 1 |
p.A259G | BLCA | 1 |
p.R136K | SKCM | 1 |
p.S81F | SKCM | 1 |
p.E198K | SKCM | 1 |
p.E121K | SKCM | 1 |
p.G447E | SKCM | 1 |
p.E90* | UCEC | 1 |
p.D182G | TGCT | 1 |
p.G193R | SKCM | 1 |
p.R310* | LUSC | 1 |
p.W422* | SKCM | 1 |
p.S472R | KIRC | 1 |
p.W204R | LUAD | 1 |
p.E29K | SKCM | 1 |
p.E92A | ESCA | 1 |
p.P532S | SKCM | 1 |
p.D505N | SKCM | 1 |
p.I67T | LIHC | 1 |
p.L568I | COAD | 1 |
p.P281S | SKCM | 1 |
p.F88L | HNSC | 1 |
p.R398G | MESO | 1 |
p.V296I | LUSC | 1 |
p.Y604H | PRAD | 1 |
p.V556G | LIHC | 1 |
p.D277N | LUAD | 1 |
p.P481Q | HNSC | 1 |
p.E323D | LUSC | 1 |
p.R4K | SKCM | 1 |
p.L185F | SKCM | 1 |
p.V60M | SKCM | 1 |
p.S506L | SKCM | 1 |
p.G14C | LUAD | 1 |
p.S271F | SKCM | 1 |
p.K116T | UCEC | 1 |
p.A231T | READ | 1 |
p.G514C | STAD | 1 |
p.D205N | SKCM | 1 |
p.K87T | UCEC | 1 |
p.L21I | LUSC | 1 |
p.D156Y | STAD | 1 |
p.G53E | SKCM | 1 |
p.G592C | OV | 1 |
p.P534S | SKCM | 1 |
p.E82K | HNSC | 1 |
p.L464F | HNSC | 1 |
p.Q92* | SKCM | 1 |
p.P160Q | ESCA | 1 |
p.F14I | COAD | 1 |
p.P586L | SKCM | 1 |
p.Q519X | SKCM | 1 |
p.D184G | TGCT | 1 |
p.G312S | SKCM | 1 |
p.P402L | SKCM | 1 |
p.L144V | PRAD | 1 |
p.I107F | SKCM | 1 |
p.E27Q | HNSC | 1 |
p.R314H | LGG | 1 |
p.E75K | BLCA | 1 |
p.G181R | SKCM | 1 |
p.V326I | BLCA | 1 |
p.E323K | SKCM | 1 |
p.S96F | SKCM | 1 |
p.E511X | COAD | 1 |
p.Q519* | SKCM | 1 |
p.L87I | COAD | 1 |
p.G502S | SKCM | 1 |
p.L192I | HNSC | 1 |
p.R195H | STAD | 1 |
p.G195R | SKCM | 1 |
p.E102K | SKCM | 1 |
p.L576I | UCEC | 1 |
p.G70R | SKCM | 1 |
p.E80K | HNSC | 1 |
p.E27K | SKCM | 1 |
p.R197H | STAD | 1 |
p.E379K | SARC | 1 |
p.H398Y | SKCM | 1 |
p.L559V | LGG | 1 |
p.S589F | SKCM | 1 |
p.D203N | SKCM | 1 |
p.L142V | PRAD | 1 |
p.D503N | SKCM | 1 |
p.G312A | BRCA | 1 |
p.L223R | STAD | 1 |
p.E71* | UCEC | 1 |
p.R535* | BRCA | 1 |
p.E321K | SKCM | 1 |
p.S79F | SKCM | 1 |
p.G447R | SKCM | 1 |
p.E29Q | HNSC | 1 |
p.L219F | LAML | 1 |
p.D312N | SKCM | 1 |
p.K529N | UCEC | 1 |
p.G16C | LUAD | 1 |
p.S169P | LIHC | 1 |
p.R310I | LUSC | 1 |
p.K30N | ESCA | 1 |
p.L183F | SKCM | 1 |
p.E95V | SKCM | 1 |
p.R385Q | SKCM | 1 |
p.E210K | SKCM | 1 |
p.R584H | GBM | 1 |
p.R34W | SKCM | 1 |
p.K291N | LUAD | 1 |
p.E375K | SKCM | 1 |
p.Y601C | LGG | 1 |
p.Q557E | BLCA | 1 |
p.E104K | SKCM | 1 |
p.G70E | SKCM | 1 |
p.R583C | UCEC | 1 |
p.L28I | LUAD | 1 |
p.R65Q | SKCM | 1 |
p.G504S | SKCM | 1 |
p.P584L | SKCM | 1 |
p.E149K | SKCM | 1 |
p.D156Y | UCEC | 1 |
p.P584S | SKCM | 1 |
p.E566K | SKCM | 1 |
p.D314N | SKCM | 1 |
p.L440Q | LGG | 1 |
p.T68M | COAD | 1 |
p.E304K | HNSC | 1 |
p.L246F | LUAD | 1 |
p.V556A | BRCA | 1 |
p.Q178R | UCEC | 1 |
p.D139E | ESCA | 1 |
p.I301K | KIRP | 1 |
p.S165L | SKCM | 1 |
p.K327N | CESC | 1 |
p.K357T | UCEC | 1 |
p.T356R | BRCA | 1 |
p.L347P | UCEC | 1 |
p.R553P | UCEC | 1 |
p.R525C | UCEC | 1 |
p.W202R | LUAD | 1 |
p.E564K | LUAD | 1 |
p.T322R | LUAD | 1 |
p.S455F | STAD | 1 |
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TissGeneCNV for PLCZ1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PLCZ1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU588824 | PLCZ1-GNPTG | chr12:18845841 | chr16:1413162 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A1KQ-01A | CLSTN3-PLCZ1 | Out-of-frame | Chr12:7295907 | Chr12:18837213 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AR-01A | KIAA0528-PLCZ1 | CDS-5UTR | Chr12:22635491 | Chr12:18890443 |
TCGAfusionPortal | PRADA | LGG | TCGA-HT-7884-01B | DENND5B-PLCZ1 | CDS-5UTR | Chr12:31648744 | Chr12:18890443 |
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TissGeneNet for PLCZ1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PLCZ1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PLCZ1 |
TissGeneDrug for PLCZ1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PLCZ1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010674 | Cystic Fibrosis | 2 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |