TissGeneSummary for FATE1 |
Gene summary |
Basic gene information | Gene symbol | FATE1 |
Gene name | fetal and adult testis expressed 1 | |
Synonyms | CT43|FATE | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_033085.2, | |
Description | BJ-HCC-2 antigencancer/testis antigen 43fetal and adult testis expressed transcript proteinfetal and adult testis-expressed transcript proteintumor antigen BJ-HCC-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300450 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147378 | ||
HPRD : 02346 | ||
Vega : OTTHUMG00000024172 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FATE1 | |
BioGPS: 89885 | ||
Pathway | NCI Pathway Interaction Database: FATE1 | |
KEGG: FATE1 | ||
REACTOME: FATE1 | ||
Pathway Commons: FATE1 | ||
Context | iHOP: FATE1 | |
ligand binding site mutation search in PubMed: FATE1 | ||
UCL Cancer Institute: FATE1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FATE1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FATE1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 3.029842504 | -0.41813944 | 3.447981944 | 1.74E-38 | 6.39E-37 |
LIHC | 0.87107556 | -1.63108844 | 2.502164 | 1.25E-15 | 4.21E-14 |
KICH | 0.93541956 | -0.38558444 | 1.321004 | 0.000338 | 0.000801024 |
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TissGene-miRNA for FATE1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FATE1 |
TissGeneSNV for FATE1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H111Y | SKCM | 3 |
p.E153K | SKCM | 2 |
p.E128Q | BRCA | 1 |
p.A10V | COAD | 1 |
p.R109H | UCEC | 1 |
p.E153K | BLCA | 1 |
p.A150T | UCEC | 1 |
p.T73N | ESCA | 1 |
p.R89* | LUAD | 1 |
p.K76M | STAD | 1 |
p.R74Q | SKCM | 1 |
p.Q183P | STAD | 1 |
p.L16M | ACC | 1 |
p.A156T | GBM | 1 |
p.E13K | CESC | 1 |
p.Y142X | KIRP | 1 |
p.W178C | TGCT | 1 |
p.R114L | LIHC | 1 |
p.R74P | UCEC | 1 |
p.G92D | UCEC | 1 |
p.W178X | LIHC | 1 |
p.Y101* | LUAD | 1 |
p.R66Q | SKCM | 1 |
p.A172G | ACC | 1 |
p.R146W | LUSC | 1 |
p.E100X | LIHC | 1 |
p.A122V | COAD | 1 |
p.S91L | SKCM | 1 |
p.R109H | PAAD | 1 |
p.Q29K | UCEC | 1 |
p.G26A | ESCA | 1 |
p.R114P | BRCA | 1 |
p.A2E | ESCA | 1 |
p.G46S | SKCM | 1 |
p.W68* | SKCM | 1 |
p.K77N | GBM | 1 |
p.H160N | LUSC | 1 |
p.N28D | COAD | 1 |
p.R114C | CESC | 1 |
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TissGeneCNV for FATE1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FATE1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK057369 | FATE1-TMEM131 | chrX:150891630 | chr2:98372803 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A08G-01A | MTMR1-FATE1 | Out-of-frame | ChrX:149887172 | ChrX:150889867 |
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TissGeneNet for FATE1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FATE1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FATE1 |
TissGeneDrug for FATE1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FATE1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0220756 | Niemann-Pick Disease, Type C | 1 | BeFree |
umls:C0432306 | Ichthyosis Bullosa of Siemens | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0750952 | Biliary Tract Cancer | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | CTD_human |