TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NAT8
check button Gene summary
Basic gene informationGene symbolNAT8
Gene nameN-acetyltransferase 8 (GCN5-related, putative)
SynonymsATase2|CCNAT|CML1|GLA|Hcml1|TSC501|TSC510
CytomapUCSC genome browser: 2p13.2
Type of geneprotein-coding
RefGenesNM_003960.3,
DescriptionN-acetyltransferase 8N-acetyltransferase 8 (camello like)acetyltransferase 2camello-like protein 1cysteinyl-conjugate N-acetyltransferasekidney- and liver-specific gene productprobable N-acetyltransferase 8
Modification date20141211
dbXrefs MIM : 606716
HGNC : HGNC
Ensembl : ENSG00000144035
HPRD : 08413
Vega : OTTHUMG00000129818
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NAT8
BioGPS: 9027
PathwayNCI Pathway Interaction Database: NAT8
KEGG: NAT8
REACTOME: NAT8
Pathway Commons: NAT8
ContextiHOP: NAT8
ligand binding site mutation search in PubMed: NAT8
UCL Cancer Institute: NAT8
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of NAT8
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006749glutathione metabolic process20392701
GO:0018003peptidyl-lysine N6-acetylation19011241
GO:0043066negative regulation of apoptotic process24556617
GO:0006749glutathione metabolic process20392701
GO:0018003peptidyl-lysine N6-acetylation19011241
GO:0043066negative regulation of apoptotic process24556617


Top
TissGeneExp for NAT8

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-2.381389776.80770223-9.1890921.08E-152.58E-14
COAD-2.468659001-1.324424385-1.1442346150.00610.014263714
KIRP6.0415758558.434119605-2.392543750.003040.007514531
LIHC5.553740237.08859823-1.5348580.000110.000377022


Top
TissGene-miRNA for NAT8

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for NAT8
TissGeneSNV for NAT8

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.M121KOV1
p.V65MSTAD1
p.R41QESCA1
p.G106DCOAD1
p.L142VLUAD1
p.D167NESCA1
p.H5DCESC1
p.A165TUCEC1
p.R7CHNSC1
p.Y101HHNSC1
p.S221PKIRC1
p.R136GLUAD1
p.H28NBRCA1
p.L39VLGG1
p.Y101HKIRP1
p.A2TUCEC1
p.L74QLUAD1
p.P40TLIHC1
p.R41QUCS1
p.E84GTHYM1
p.R7PHNSC1
p.R23WCOAD1
p.K195NSTAD1
p.R150GLUAD1
p.G24WUCEC1
p.S183CBLCA1
p.D167HLUAD1
p.E104KDLBC1
p.D13GHNSC1
p.P3SCESC1
p.L102PKIRC1
p.P50LHNSC1
p.T160IUCEC1
p.R7SHNSC1
p.T160NLIHC1
p.A52TLGG1
p.R41QUCEC1
p.A29VCOAD1
p.M191TBLCA1
p.H218YESCA1
p.M121VKIRP1
p.G120DSTAD1
p.R166QSTAD1
p.S183FBLCA1
p.G58RREAD1
p.A124SCOAD1


Top
TissGeneCNV for NAT8

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for NAT8

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


Top
TissGeneNet for NAT8

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
NAT8, HNF4A, SMAD4, TOP1 (tumor)NAT8, HNF4A, SMAD4, TOP1 (normal)
bullet pointbullet point


Top
TissGeneProg for NAT8

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for NAT8
TissGeneDrug for NAT8

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for NAT8

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0002986Fabry Disease30BeFree
umls:C0699885Carcinoma of bladder12BeFree
umls:C0005684Malignant neoplasm of urinary bladder11BeFree
umls:C0006142Malignant neoplasm of breast9BeFree
umls:C0009402Colorectal Carcinoma9BeFree
umls:C0678222Breast Carcinoma9BeFree
umls:C0041296Tuberculosis8BeFree
umls:C1527249Colorectal Cancer8BeFree
umls:C0003873Rheumatoid Arthritis5BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C1827377Slow acetylator due to N-acetyltransferase enzyme variant5BeFree
umls:C0546837Malignant neoplasm of esophagus4BeFree
umls:C0014859Esophageal Neoplasms3BeFree
umls:C0015230Exanthema3BeFree
umls:C0021390Inflammatory Bowel Diseases3BeFree
umls:C0024141Lupus Erythematosus, Systemic3BeFree
umls:C0038454Cerebrovascular accident3BeFree
umls:C0152018Esophageal carcinoma3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C0848332Spots on skin3BeFree
umls:C1262760Hepatitis, Drug-Induced3BeFree
umls:C1561643Chronic Kidney Diseases3BeFree,GWASCAT
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0020538Hypertensive disease2BeFree
umls:C0022658Kidney Diseases2BeFree,GAD
umls:C0022661Kidney Failure, Chronic2BeFree,GAD
umls:C0403447Chronic Kidney Insufficiency2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0751688Malignant Squamous Cell Neoplasm2BeFree
umls:C0948008Ischemic stroke2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0008925Cleft Palate1BeFree
umls:C0017601Glaucoma1BeFree
umls:C0019158Hepatitis1BeFree
umls:C0019159Hepatitis A1BeFree
umls:C0020544Renal hypertension1GAD
umls:C0021364Male infertility1BeFree
umls:C0023418leukemia1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023891Liver Cirrhosis, Alcoholic1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0033847Pseudoxanthoma Elasticum1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0151945Thrombosis of cerebral veins1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0280324Laryngeal Squamous Cell Carcinoma1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree