TissGeneSummary for TGIF2LX |
Gene summary |
Basic gene information | Gene symbol | TGIF2LX |
Gene name | TGFB-induced factor homeobox 2-like, X-linked | |
Synonyms | TGIFLX | |
Cytomap | UCSC genome browser: Xq21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_138960.3, | |
Description | TGF-beta-induced transcription factor 2-like proteinTGFB-induced factor 2-like protein, X-linkedTGFB-induced factor 2-like, X-linkedTGIF-like on the Xhomeobox protein TGIF2LX | |
Modification date | 20141207 | |
dbXrefs | MIM : 300411 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153779 | ||
HPRD : 02328 | ||
Vega : OTTHUMG00000021954 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TGIF2LX | |
BioGPS: 90316 | ||
Pathway | NCI Pathway Interaction Database: TGIF2LX | |
KEGG: TGIF2LX | ||
REACTOME: TGIF2LX | ||
Pathway Commons: TGIF2LX | ||
Context | iHOP: TGIF2LX | |
ligand binding site mutation search in PubMed: TGIF2LX | ||
UCL Cancer Institute: TGIF2LX | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TGIF2LX | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TGIF2LX |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 0.927961885 | -0.199202115 | 1.127164 | 1.66E-05 | 6.68E-05 |
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TissGene-miRNA for TGIF2LX |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TGIF2LX |
TissGeneSNV for TGIF2LX |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E16K | SKCM | 2 |
p.A224T | LIHC | 2 |
p.L92M | LUSC | 1 |
p.R116C | BLCA | 1 |
p.L65I | LUAD | 1 |
p.A38T | HNSC | 1 |
p.R169T | THCA | 1 |
p.R116H | LUAD | 1 |
p.P78L | SKCM | 1 |
p.N91K | LUSC | 1 |
p.K182M | BLCA | 1 |
p.P179T | LIHC | 1 |
p.A144T | GBM | 1 |
p.R105H | UCEC | 1 |
p.P241S | SARC | 1 |
p.V142A | STAD | 1 |
p.Q24K | LUAD | 1 |
p.A5V | COAD | 1 |
p.I64M | LUAD | 1 |
p.A187T | BLCA | 1 |
p.V62F | LUAD | 1 |
p.Q181H | HNSC | 1 |
p.D39E | LGG | 1 |
p.E238* | LUAD | 1 |
p.E2G | CESC | 1 |
p.A4T | HNSC | 1 |
p.D222Y | LUSC | 1 |
p.W100L | LUAD | 1 |
p.P143Q | LUSC | 1 |
p.R116H | STAD | 1 |
p.R73W | UCEC | 1 |
p.A223E | LUSC | 1 |
p.K145R | STAD | 1 |
p.K52T | ESCA | 1 |
p.E82D | UCEC | 1 |
p.H131L | LUSC | 1 |
p.H131Y | SKCM | 1 |
p.E80A | SKCM | 1 |
p.R117* | LUSC | 1 |
p.K236T | LUSC | 1 |
p.R35I | LUAD | 1 |
p.E139K | BLCA | 1 |
p.D67N | UCEC | 1 |
p.P163A | UCEC | 1 |
p.P143S | BLCA | 1 |
p.K194N | COAD | 1 |
p.S149N | LUAD | 1 |
p.S98T | LUSC | 1 |
p.H49P | SKCM | 1 |
p.P241T | LUSC | 1 |
p.D152N | BLCA | 1 |
p.E48* | LUAD | 1 |
p.R42S | LUAD | 1 |
p.K164N | LIHC | 1 |
p.E10* | HNSC | 1 |
p.S168* | LUAD | 1 |
p.E2K | SKCM | 1 |
p.V206M | LUAD | 1 |
p.P189R | LUAD | 1 |
p.P179R | LIHC | 1 |
p.R107G | LUAD | 1 |
p.H72P | STAD | 1 |
p.D213N | UCEC | 1 |
p.P8L | ESCA | 1 |
p.Q166K | HNSC | 1 |
p.N36K | LUAD | 1 |
p.K194* | SKCM | 1 |
p.D119N | COAD | 1 |
p.V197I | COAD | 1 |
p.R169G | COAD | 1 |
p.R107H | PAAD | 1 |
p.G185R | BLCA | 1 |
p.P189L | PAAD | 1 |
p.L109I | COAD | 1 |
p.P158H | KIRC | 1 |
p.E170G | LUSC | 1 |
p.N103K | BLCA | 1 |
p.K145T | STAD | 1 |
p.N37S | LUAD | 1 |
p.L183F | LUAD | 1 |
p.P20S | LUAD | 1 |
p.L57M | STAD | 1 |
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TissGeneCNV for TGIF2LX |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TGIF2LX |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TGIF2LX |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TGIF2LX |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TGIF2LX |
TissGeneDrug for TGIF2LX |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TGIF2LX |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0041408 | Turner Syndrome | 1 | BeFree |
umls:C0085215 | Ovarian Failure, Premature | 1 | BeFree |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |