TissGeneSummary for DUOXA1 |
Gene summary |
Basic gene information | Gene symbol | DUOXA1 |
Gene name | dual oxidase maturation factor 1 | |
Synonyms | NIP|NUMBIP|mol | |
Cytomap | UCSC genome browser: 15q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001276264.1, NM_001276265.1,NM_001276266.1,NM_001276267.1,NM_001276268.1, NM_144565.3, | |
Description | dual oxidase activator 1dual oxidase maturation factor 1 alphadual oxidase maturation factor 1 betadual oxidase maturation factor 1 deltadual oxidase maturation factor 1 gammahomolog of Drosophila Numb-interacting protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 612771 | |
HGNC : HGNC | ||
Ensembl : ENSG00000140254 | ||
HPRD : 14829 | ||
Vega : OTTHUMG00000131352 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUOXA1 | |
BioGPS: 90527 | ||
Pathway | NCI Pathway Interaction Database: DUOXA1 | |
KEGG: DUOXA1 | ||
REACTOME: DUOXA1 | ||
Pathway Commons: DUOXA1 | ||
Context | iHOP: DUOXA1 | |
ligand binding site mutation search in PubMed: DUOXA1 | ||
UCL Cancer Institute: DUOXA1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTHCA | |
Reference showing the relevant tissue of DUOXA1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DUOXA1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 1.470945554 | 3.781251323 | -2.310305769 | 3.03E-11 | 8.18E-10 |
LUSC | 3.883271534 | 5.596640162 | -1.713368627 | 1.25E-08 | 3.91E-08 |
KIRC | -3.083740557 | -1.616489168 | -1.467251389 | 7.54E-14 | 3.51E-13 |
LUAD | 2.611222278 | 5.735946416 | -3.124724138 | 2.35E-17 | 3.01E-16 |
KICH | -2.712131446 | -1.072063446 | -1.640068 | 6.32E-05 | 0.000172179 |
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TissGene-miRNA for DUOXA1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DUOXA1 |
TissGeneSNV for DUOXA1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R332C | HNSC | 2 |
p.T23A | BLCA | 1 |
p.S26I | STAD | 1 |
p.W207C | LUAD | 1 |
p.R174L | KIRC | 1 |
p.G114R | UCEC | 1 |
p.R129L | KIRC | 1 |
p.P43R | CESC | 1 |
p.S296N | UCEC | 1 |
p.R174C | KIRC | 1 |
p.E288K | LIHC | 1 |
p.S277* | CESC | 1 |
p.G104W | ESCA | 1 |
p.A266V | LUAD | 1 |
p.R478C | ACC | 1 |
p.Q272R | STAD | 1 |
p.P19L | SKCM | 1 |
p.G104R | UCEC | 1 |
p.H232Y | SKCM | 1 |
p.E333K | LIHC | 1 |
p.D457N | SKCM | 1 |
p.W363* | STAD | 1 |
p.A131V | HNSC | 1 |
p.T37M | KIRP | 1 |
p.G311E | SKCM | 1 |
p.K99N | CESC | 1 |
p.Y81H | SKCM | 1 |
p.S322* | CESC | 1 |
p.G64R | BLCA | 1 |
p.A347S | LUAD | 1 |
p.R129C | KIRC | 1 |
p.V287M | OV | 1 |
p.E83K | SKCM | 1 |
p.E77Q | HNSC | 1 |
p.F465L | HNSC | 1 |
p.R460H | COAD | 1 |
p.E93K | HNSC | 1 |
p.V57M | COAD | 1 |
p.R433C | ACC | 1 |
p.Q317R | STAD | 1 |
p.S86P | STAD | 1 |
p.L112V | LIHC | 1 |
p.G443D | COAD | 1 |
p.A311V | LUAD | 1 |
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TissGeneCNV for DUOXA1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DUOXA1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for DUOXA1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DUOXA1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DUOXA1 |
TissGeneDrug for DUOXA1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DUOXA1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0010308 | Congenital Hypothyroidism | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271795 | Transient hypothyroidism | 1 | BeFree |
umls:C0342200 | Endemic Cretinism | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |