TissGeneSummary for PIAS2 |
Gene summary |
Basic gene information | Gene symbol | PIAS2 |
Gene name | protein inhibitor of activated STAT, 2 | |
Synonyms | ARIP3|DIP|MIZ|MIZ1|PIASX|PIASX-ALPHA|PIASX-BETA|SIZ2|ZMIZ4 | |
Cytomap | UCSC genome browser: 18q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_004671.3, NM_173206.3, | |
Description | DAB2-interacting proteinE3 SUMO-protein ligase PIAS2androgen receptor-interacting protein 3msx-interacting zinc finger proteinprotein inhibitor of activated STAT Xzinc finger, MIZ-type containing 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603567 | |
HGNC : HGNC | ||
Ensembl : ENSG00000078043 | ||
HPRD : 06944 | ||
Vega : OTTHUMG00000179301 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PIAS2 | |
BioGPS: 9063 | ||
Pathway | NCI Pathway Interaction Database: PIAS2 | |
KEGG: PIAS2 | ||
REACTOME: PIAS2 | ||
Pathway Commons: PIAS2 | ||
Context | iHOP: PIAS2 | |
ligand binding site mutation search in PubMed: PIAS2 | ||
UCL Cancer Institute: PIAS2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PIAS2 | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016925 | protein sumoylation | 22406621 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 11477070 | GO:0016925 | protein sumoylation | 22406621 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 11477070 |
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TissGeneExp for PIAS2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PIAS2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-340-5p | MIMAT0004692 | 0.047 | -0.27 | 56 |
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TissGeneMut for PIAS2 |
TissGeneSNV for PIAS2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S519L | COAD | 2 |
p.R63H | UCEC | 1 |
p.R67Q | STAD | 1 |
p.S278F | SKCM | 1 |
p.R33H | UCEC | 1 |
p.S587G | STAD | 1 |
p.R352S | LUAD | 1 |
p.S81L | UCEC | 1 |
p.S280Y | SKCM | 1 |
p.F368L | KIRP | 1 |
p.D421V | KICH | 1 |
p.E334* | HNSC | 1 |
p.R488S | READ | 1 |
p.R352M | LUAD | 1 |
p.R67* | UCEC | 1 |
p.K162E | PAAD | 1 |
p.S599I | STAD | 1 |
p.K435E | HNSC | 1 |
p.P105L | SKCM | 1 |
p.K379R | COAD | 1 |
p.S519L | OV | 1 |
p.T569N | UCEC | 1 |
p.P440L | UCEC | 1 |
p.T363K | KIRC | 1 |
p.P128S | SKCM | 1 |
p.D483H | HNSC | 1 |
p.D145N | LUSC | 1 |
p.L556P | STAD | 1 |
p.L148F | SKCM | 1 |
p.P347H | STAD | 1 |
p.S519L | UCEC | 1 |
p.D224Y | LUAD | 1 |
p.D204Y | OV | 1 |
p.S499N | STAD | 1 |
p.E480K | CESC | 1 |
p.R341W | UCEC | 1 |
p.T593A | STAD | 1 |
p.I614T | STAD | 1 |
p.R33C | STAD | 1 |
p.E6* | UCEC | 1 |
p.S265Y | UCEC | 1 |
p.E59* | UCEC | 1 |
p.K149N | UCEC | 1 |
p.Q175R | STAD | 1 |
p.Q133H | PAAD | 1 |
p.E325X | READ | 1 |
p.S602T | BRCA | 1 |
p.R58* | STAD | 1 |
p.L554I | READ | 1 |
p.P484H | UCEC | 1 |
p.R297G | UCEC | 1 |
p.R259H | THYM | 1 |
p.H318Y | LUAD | 1 |
p.D332H | HNSC | 1 |
p.T382I | KIRP | 1 |
p.L211F | ACC | 1 |
p.A52V | THCA | 1 |
p.D468H | BLCA | 1 |
p.S411F | SKCM | 1 |
p.D196N | UCEC | 1 |
p.T354S | LUSC | 1 |
p.S80* | UCEC | 1 |
p.R341Q | SKCM | 1 |
p.H538R | BRCA | 1 |
p.R297L | SKCM | 1 |
p.P453S | SKCM | 1 |
p.M427I | BRCA | 1 |
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TissGeneCNV for PIAS2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PIAS2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA244401 | PIAS2-PIAS2 | chr18:44401128 | chr18:44400857 | |
Chimerdb3.0 | ChiTaRs | NA | AA244416 | PIAS2-PIAS2 | chr18:44400928 | chr18:44400956 | |
Chimerdb3.0 | FusionScan | LUSC | TCGA-58-8390-01A | PIAS2-ST8SIA5 | In-Frame | chr18:44407921 | chr18:44272218 |
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TissGeneNet for PIAS2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PIAS2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PIAS2 |
TissGeneDrug for PIAS2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PIAS2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027819 | Neuroblastoma | 4 | BeFree |
umls:C0700095 | Central neuroblastoma | 4 | BeFree |
umls:C0263746 | Osteoarthritis of the hand | 2 | BeFree |
umls:C0409957 | Osteoarthritis of distal interphalangeal joint | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0027339 | Nail Diseases | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0032969 | Pregnancy in Diabetics | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
umls:C0079772 | T-Cell Lymphoma | 1 | BeFree |
umls:C0085207 | Gestational Diabetes | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |