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| TissGeneSummary for PIAS2 |
 Gene summary |
| Basic gene information | Gene symbol | PIAS2 |
| Gene name | protein inhibitor of activated STAT, 2 | |
| Synonyms | ARIP3|DIP|MIZ|MIZ1|PIASX|PIASX-ALPHA|PIASX-BETA|SIZ2|ZMIZ4 | |
| Cytomap | UCSC genome browser: 18q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004671.3, NM_173206.3, | |
| Description | DAB2-interacting proteinE3 SUMO-protein ligase PIAS2androgen receptor-interacting protein 3msx-interacting zinc finger proteinprotein inhibitor of activated STAT Xzinc finger, MIZ-type containing 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603567 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000078043 | ||
| HPRD : 06944 | ||
| Vega : OTTHUMG00000179301 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIAS2 | |
| BioGPS: 9063 | ||
| Pathway | NCI Pathway Interaction Database: PIAS2 | |
| KEGG: PIAS2 | ||
| REACTOME: PIAS2 | ||
| Pathway Commons: PIAS2 | ||
| Context | iHOP: PIAS2 | |
| ligand binding site mutation search in PubMed: PIAS2 | ||
| UCL Cancer Institute: PIAS2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of PIAS2 | ||
| Description by TissGene annotations | Cancer gene TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016925 | protein sumoylation | 22406621 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 11477070 | GO:0016925 | protein sumoylation | 22406621 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 11477070 |
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| TissGeneExp for PIAS2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PIAS2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-340-5p | MIMAT0004692 | 0.047 | -0.27 | 56 |
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| TissGeneMut for PIAS2 |
| TissGeneSNV for PIAS2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S519L | COAD | 2 |
| p.R63H | UCEC | 1 |
| p.R67Q | STAD | 1 |
| p.S278F | SKCM | 1 |
| p.R33H | UCEC | 1 |
| p.S587G | STAD | 1 |
| p.R352S | LUAD | 1 |
| p.S81L | UCEC | 1 |
| p.S280Y | SKCM | 1 |
| p.F368L | KIRP | 1 |
| p.D421V | KICH | 1 |
| p.E334* | HNSC | 1 |
| p.R488S | READ | 1 |
| p.R352M | LUAD | 1 |
| p.R67* | UCEC | 1 |
| p.K162E | PAAD | 1 |
| p.S599I | STAD | 1 |
| p.K435E | HNSC | 1 |
| p.P105L | SKCM | 1 |
| p.K379R | COAD | 1 |
| p.S519L | OV | 1 |
| p.T569N | UCEC | 1 |
| p.P440L | UCEC | 1 |
| p.T363K | KIRC | 1 |
| p.P128S | SKCM | 1 |
| p.D483H | HNSC | 1 |
| p.D145N | LUSC | 1 |
| p.L556P | STAD | 1 |
| p.L148F | SKCM | 1 |
| p.P347H | STAD | 1 |
| p.S519L | UCEC | 1 |
| p.D224Y | LUAD | 1 |
| p.D204Y | OV | 1 |
| p.S499N | STAD | 1 |
| p.E480K | CESC | 1 |
| p.R341W | UCEC | 1 |
| p.T593A | STAD | 1 |
| p.I614T | STAD | 1 |
| p.R33C | STAD | 1 |
| p.E6* | UCEC | 1 |
| p.S265Y | UCEC | 1 |
| p.E59* | UCEC | 1 |
| p.K149N | UCEC | 1 |
| p.Q175R | STAD | 1 |
| p.Q133H | PAAD | 1 |
| p.E325X | READ | 1 |
| p.S602T | BRCA | 1 |
| p.R58* | STAD | 1 |
| p.L554I | READ | 1 |
| p.P484H | UCEC | 1 |
| p.R297G | UCEC | 1 |
| p.R259H | THYM | 1 |
| p.H318Y | LUAD | 1 |
| p.D332H | HNSC | 1 |
| p.T382I | KIRP | 1 |
| p.L211F | ACC | 1 |
| p.A52V | THCA | 1 |
| p.D468H | BLCA | 1 |
| p.S411F | SKCM | 1 |
| p.D196N | UCEC | 1 |
| p.T354S | LUSC | 1 |
| p.S80* | UCEC | 1 |
| p.R341Q | SKCM | 1 |
| p.H538R | BRCA | 1 |
| p.R297L | SKCM | 1 |
| p.P453S | SKCM | 1 |
| p.M427I | BRCA | 1 |
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| TissGeneCNV for PIAS2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PIAS2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA244401 | PIAS2-PIAS2 | chr18:44401128 | chr18:44400857 | |
| Chimerdb3.0 | ChiTaRs | NA | AA244416 | PIAS2-PIAS2 | chr18:44400928 | chr18:44400956 | |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-58-8390-01A | PIAS2-ST8SIA5 | In-Frame | chr18:44407921 | chr18:44272218 |
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| TissGeneNet for PIAS2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PIAS2, TP53, NR3C1, CHMP4B, MBD1, HDAC3, PIAS4, HUWE1, AR, TRAF2, UBE2I, TRIM27, NGFR, AKT1, MITF, PIAS1, TOPBP1, UBA2, ESR2, GTF2I, RUFY1 (tumor) | PIAS2, UBC, CHMP4B, JUN, MBD1, YWHAQ, MAPK8, HUWE1, SMAD4, TRAF2, AKT1, NEDD8, SNIP1, PARK7, PIAS1, TOPBP1, UBA2, HIC1, GTF2I, C1QA, NAV2 (normal) |
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| COAD (tumor) | COAD (normal) |
| PIAS2, UBC, CHMP4B, DNMT3A, EPAS1, TRAF2, TRIM27, SIAH1, NTRK1, ELK1, PGR, SREBF2, PARP1, GLUL, MITF, PARK7, UBA2, GTF2I, IFIH1, SAE1, NAV2 (tumor) | PIAS2, UBC, CHMP4B, JUN, MBD1, MAPK8, SMAD4, UBE2I, AKT1, SIAH1, NTRK1, PARP1, STAT4, PIAS1, ESR2, GFI1, C1QA, GTF2IRD1, FLI1, GRM8, ZBTB4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PIAS2, NR3C1, CHMP4B, SUMO2, HDAC3, SUMO1, DNMT3A, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, ELK1, NEDD8, SIAH2, MITF, GTF2I, TICAM2, SAE1, ADA (tumor) | PIAS2, UBC, MSX2, MYCN, DNMT3A, MAPK8, HUWE1, AR, SMAD4, PML, ELK1, NEDD8, PARP1, GLUL, PARK7, PIAS1, TOPBP1, UBA2, GTF2I, IFIH1, GRM8 (normal) |
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| KICH (tumor) | KICH (normal) |
| PIAS2, CHMP4B, CDKN2A, EPAS1, MAPK8, TRAF2, UBE2I, TRIM27, PML, ELK1, STAT4, SIAH2, GLUL, PARK7, TOPBP1, HIC1, GFI1, FLI1, SAE1, NAV2, MAGEA4 (tumor) | PIAS2, NR3C1, JUN, MBD1, MAPK8, HUWE1, SMAD4, TRAF2, TRIM27, PML, NTRK1, ELK1, NEDD8, PIAS1, TOPBP1, UBA2, HIC1, GTF2I, TICAM2, C1QA, ADA (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PIAS2, CHMP4B, SUMO2, YWHAQ, MYCN, MAPK8, HUWE1, TRAF2, UBE2I, AKT1, PML, NEDD8, GLUL, PIAS1, ITGB5, HIC1, C1QA, RUFY1, SAE1, NAV2, ADA (tumor) | PIAS2, CHMP4B, MBD1, CDKN2A, MAPK8, HUWE1, SMAD4, TRAF2, UBE2I, PML, PGR, SREBF2, STAT4, MITF, PARK7, PIAS1, TOPBP1, GTF2I, TICAM2, ADA, ZBTB4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PIAS2, NR3C1, CHMP4B, SUMO2, HDAC3, EPAS1, MAPK8, HUWE1, AR, TRAF2, UBE2I, TRIM27, AKT1, PML, CLDN2, PIAS1, GTF2I, TICAM2, RUFY1, SAE1, NAV2 (tumor) | PIAS2, NR3C1, CHMP4B, SUMO2, MBD1, PIAS4, EPAS1, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, NEDD8, PARP1, PARK7, PIAS1, TOPBP1, UBA2, GTF2I, IFIH1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PIAS2, NR3C1, CHMP4B, ESR1, YWHAQ, SUMO1, MAPK8, HUWE1, AR, SMAD4, UBE2I, NEDD8, PGR, PARP1, SNIP1, PARK7, PIAS1, TOPBP1, GTF2I, FLI1, ZBTB4 (tumor) | PIAS2, NR3C1, CHMP4B, MBD1, YWHAQ, SUMO1, EPAS1, MAPK8, HUWE1, SMAD4, NEDD8, SNIP1, MITF, PARK7, PIAS1, TOPBP1, UBA2, GTF2I, IFIH1, NAV2, GRM8 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PIAS2, NR3C1, CHMP4B, DNMT3A, MYC, MAPK8, SMAD4, TRAF2, AKT1, NEDD8, SIAH2, SNIP1, MITF, PARK7, PIAS1, TOPBP1, ESR2, GTF2I, TICAM2, FLI1, SAE1 (tumor) | PIAS2, UBC, CHMP4B, JUN, MSX2, MBD1, YWHAQ, DNMT3A, MAPK8, AR, SMAD4, PML, PARP1, SIAH2, TOPBP1, UBA2, GTF2I, SAE1, ADA, GRM8, MAGEA4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PIAS2, TP53, NR3C1, CHMP4B, HDAC3, DNMT3A, MYC, MAPK8, HUWE1, TRAF2, ELK1, CLDN2, GLUL, SNIP1, MITF, PIAS1, TOPBP1, GTF2I, GTF2IRD1, FLI1, MAGEA4 (tumor) | PIAS2, CHMP4B, SUMO2, MBD1, ESR1, EPAS1, SMAD4, TRAF2, PML, ELK1, PARP1, STAT4, SIAH2, PIAS1, TOPBP1, UBA2, HIC1, GTF2I, RUFY1, IFIH1, MAGEA4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PIAS2, MSX2, SUMO1, DNMT3A, EPAS1, MAPK8, AR, TRAF2, TRIM27, AKT1, PML, ELK1, SREBF2, CLDN2, PIAS1, UBA2, TICAM2, C1QA, GTF2IRD1, RUFY1, IFIH1 (tumor) | PIAS2, UBC, CHMP4B, SUMO2, MBD1, YWHAQ, SUMO1, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, NEDD8, SNIP1, PARK7, PIAS1, TOPBP1, UBA2, GTF2I, C1QA (normal) |
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| STAD (tumor) | STAD (normal) |
| PIAS2, NR3C1, CDKN2A, YWHAQ, MYCN, DNMT3A, AR, SMAD4, TRAF2, TRIM27, NGFR, PGR, CLDN2, MITF, UBA2, ESR2, GTF2I, SAE1, NAV2, ADA, ZBTB4 (tumor) | PIAS2, UBC, CHMP4B, SUMO2, MSX2, MBD1, SUMO1, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, PML, NEDD8, PARP1, SNIP1, PIAS1, TOPBP1, GTF2I, ZBTB4 (normal) |
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| THCA (tumor) | THCA (normal) |
| PIAS2, CHMP4B, SUMO2, CDKN2A, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, ELK1, NEDD8, SNIP1, PARK7, PIAS1, GTF2I, C1QA, NAV2, ADA, GRM8, ZBTB4 (tumor) | PIAS2, NR3C1, CHMP4B, SUMO2, CDKN2A, EPAS1, MAPK8, HUWE1, AR, SMAD4, TRAF2, UBE2I, PML, NEDD8, PARP1, STAT4, SIAH2, PIAS1, TOPBP1, GTF2I, C1QA (normal) |
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| TissGeneProg for PIAS2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PIAS2 |
| TissGeneDrug for PIAS2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PIAS2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027819 | Neuroblastoma | 4 | BeFree |
| umls:C0700095 | Central neuroblastoma | 4 | BeFree |
| umls:C0263746 | Osteoarthritis of the hand | 2 | BeFree |
| umls:C0409957 | Osteoarthritis of distal interphalangeal joint | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027339 | Nail Diseases | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032969 | Pregnancy in Diabetics | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0079772 | T-Cell Lymphoma | 1 | BeFree |
| umls:C0085207 | Gestational Diabetes | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
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