TissGeneSummary for CLDN10 |
Gene summary |
Basic gene information | Gene symbol | CLDN10 |
Gene name | claudin 10 | |
Synonyms | CPETRL3|OSP-L | |
Cytomap | UCSC genome browser: 13q31-q34 | |
Type of gene | protein-coding | |
RefGenes | NM_001160100.1, NM_006984.4,NM_182848.3, | |
Description | OSP-like proteinclaudin-10 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000134873 | ||
HPRD : 13063 | ||
Vega : OTTHUMG00000017217 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CLDN10 | |
BioGPS: 9071 | ||
Pathway | NCI Pathway Interaction Database: CLDN10 | |
KEGG: CLDN10 | ||
REACTOME: CLDN10 | ||
Pathway Commons: CLDN10 | ||
Context | iHOP: CLDN10 | |
ligand binding site mutation search in PubMed: CLDN10 | ||
UCL Cancer Institute: CLDN10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPAAD | |
Reference showing the relevant tissue of CLDN10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CLDN10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 1.308623494 | -1.323788575 | 2.632412069 | 2.11E-07 | 7.84E-07 |
KIRP | 3.109815089 | 5.952036964 | -2.842221875 | 6.85E-10 | 6.59E-09 |
KICH | -2.622592161 | 6.352887839 | -8.97548 | 1.60E-13 | 2.23E-12 |
KIRC | 3.426613006 | 5.971551895 | -2.544938889 | 8.97E-31 | 1.83E-29 |
LIHC | -2.578992161 | 1.657873839 | -4.236866 | 1.14E-11 | 1.77E-10 |
HNSC | -3.569602207 | 1.684386165 | -5.253988372 | 5.34E-12 | 1.52E-10 |
THCA | 1.067012653 | -3.885200907 | 4.952213559 | 9.22E-15 | 1.13E-13 |
BRCA | -3.579378441 | -1.032364406 | -2.547014035 | 1.39E-21 | 1.11E-20 |
COAD | -2.551639238 | -4.177139238 | 1.6255 | 0.0207 | 0.041343391 |
LUSC | 0.324493643 | -0.760369102 | 1.084862745 | 0.0149 | 0.022998492 |
Top |
TissGene-miRNA for CLDN10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CLDN10 |
TissGeneSNV for CLDN10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S16L | SKCM | 1 |
p.V20I | LUSC | 1 |
p.R204Q | SKCM | 1 |
p.N54K | LUSC | 1 |
p.G74_splice | UCEC | 1 |
p.R33Q | LUSC | 1 |
p.Y29C | UCEC | 1 |
p.S58Y | BLCA | 1 |
p.G37S | STAD | 1 |
p.S58Y | READ | 1 |
p.I82M | HNSC | 1 |
p.Q45X | SKCM | 1 |
p.T27A | UCEC | 1 |
p.G196E | LUSC | 1 |
p.N223K | LUAD | 1 |
p.V32L | COAD | 1 |
p.G14X | ESCA | 1 |
p.N225K | LUAD | 1 |
p.F146L | COAD | 1 |
p.A10T | COAD | 1 |
p.M99I | PRAD | 1 |
p.I84M | HNSC | 1 |
p.D65N | SKCM | 1 |
p.T32M | LUAD | 1 |
p.K139I | SKCM | 1 |
p.D212H | KIRC | 1 |
p.F68C | CESC | 1 |
p.F146L | UCEC | 1 |
p.G14R | COAD | 1 |
p.A10V | HNSC | 1 |
p.D73Y | LUAD | 1 |
p.S197Y | LUAD | 1 |
p.C61* | LUAD | 1 |
p.N223T | SKCM | 1 |
p.A55V | STAD | 1 |
p.R33Q | SKCM | 1 |
p.W48R | UCEC | 1 |
p.R202W | HNSC | 1 |
p.S16L | LUAD | 1 |
p.F146L | READ | 1 |
p.M132V | UCEC | 1 |
p.C53G | SKCM | 1 |
p.R3M | LUAD | 1 |
p.H206Y | SKCM | 1 |
p.A197V | COAD | 1 |
p.I76M | UCEC | 1 |
p.V60I | THYM | 1 |
p.F89S | HNSC | 1 |
p.Q45* | SKCM | 1 |
p.T216A | UCEC | 1 |
p.I76M | COAD | 1 |
p.R62L | OV | 1 |
p.V150I | SARC | 1 |
p.A85T | UCEC | 1 |
p.G37D | COAD | 1 |
p.R202Q | SKCM | 1 |
Top |
TissGeneCNV for CLDN10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CLDN10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP333889 | STATH-CLDN10 | chr4:70868094 | chr13:96103484 | |
TCGAfusionPortal | PRADA | HNSC | TCGA-CR-6467-01A | CLDN10-TTC12 | In-frame | Chr13:96212717 | Chr11:113220795 |
Top |
TissGeneNet for CLDN10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CLDN10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CLDN10 |
TissGeneDrug for CLDN10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CLDN10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 2 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |