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TissGeneSummary for TIMD4 |
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Basic gene information | Gene symbol | TIMD4 |
Gene name | T-cell immunoglobulin and mucin domain containing 4 | |
Synonyms | SMUCKLER|TIM4 | |
Cytomap | UCSC genome browser: 5q33.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001146726.1, NM_138379.2, | |
Description | T-cell immunoglobulin and mucin domain-containing protein 4T-cell immunoglobulin mucin receptor 4T-cell membrane protein 4TIM-4TIMD-4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610096 | |
HGNC : HGNC | ||
Ensembl : ENSG00000145850 | ||
HPRD : 15508 | ||
Vega : OTTHUMG00000130244 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TIMD4 | |
BioGPS: 91937 | ||
Pathway | NCI Pathway Interaction Database: TIMD4 | |
KEGG: TIMD4 | ||
REACTOME: TIMD4 | ||
Pathway Commons: TIMD4 | ||
Context | iHOP: TIMD4 | |
ligand binding site mutation search in PubMed: TIMD4 | ||
UCL Cancer Institute: TIMD4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TIMD4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for TIMD4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.382028998 | 1.279956775 | 1.102072222 | 2.20E-06 | 5.47E-06 |
KICH | 4.660905164 | 1.255913164 | 3.404992 | 7.16E-06 | 2.33E-05 |
LIHC | -1.346944836 | 3.077969164 | -4.424914 | 3.53E-19 | 2.01E-17 |
KIRP | 2.508039414 | 1.164130039 | 1.343909375 | 0.000519 | 0.001519057 |
COAD | -1.860055297 | -0.285497605 | -1.574557692 | 0.000485 | 0.001500897 |
LUSC | -1.678835463 | -0.094984483 | -1.58385098 | 5.46E-05 | 0.000116109 |
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TissGene-miRNA for TIMD4 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TIMD4 |
TissGeneSNV for TIMD4 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S44F | SKCM | 3 |
p.D122N | SKCM | 2 |
p.G73R | SKCM | 2 |
p.G368R | SKCM | 2 |
p.R147H | UCEC | 2 |
p.A67V | UCEC | 1 |
p.A245T | COAD | 1 |
p.R128H | COAD | 1 |
p.S264P | STAD | 1 |
p.L260H | LIHC | 1 |
p.D357N | BLCA | 1 |
p.V36M | BRCA | 1 |
p.A67V | COAD | 1 |
p.T29M | COAD | 1 |
p.P5T | LUSC | 1 |
p.A333V | COAD | 1 |
p.P164S | SKCM | 1 |
p.L340H | COAD | 1 |
p.W237* | LUAD | 1 |
p.L19Q | LUAD | 1 |
p.A320V | SKCM | 1 |
p.S78L | SKCM | 1 |
p.Q184* | SKCM | 1 |
p.T201A | SKCM | 1 |
p.S51N | SKCM | 1 |
p.T137N | LUAD | 1 |
p.W54R | HNSC | 1 |
p.E4D | COAD | 1 |
p.M310L | LGG | 1 |
p.D57N | SKCM | 1 |
p.T29M | HNSC | 1 |
p.E208K | SKCM | 1 |
p.Q298K | LUAD | 1 |
p.P39H | THYM | 1 |
p.R79I | BLCA | 1 |
p.R140K | SKCM | 1 |
p.R128H | ESCA | 1 |
p.N101T | PAAD | 1 |
p.L8H | SKCM | 1 |
p.P206Q | LUAD | 1 |
p.P303H | LIHC | 1 |
p.D57N | BLCA | 1 |
p.Q290K | LUAD | 1 |
p.T77I | SKCM | 1 |
p.A226S | PRAD | 1 |
p.L232F | SKCM | 1 |
p.T210I | LUSC | 1 |
p.V172L | LUAD | 1 |
p.D235N | SKCM | 1 |
p.W269* | SKCM | 1 |
p.P164L | LUAD | 1 |
p.V266M | BLCA | 1 |
p.Q184X | SKCM | 1 |
p.T71N | LUAD | 1 |
p.P202S | LGG | 1 |
p.L249R | LUAD | 1 |
p.E115* | UCEC | 1 |
p.S283C | BLCA | 1 |
p.D284N | LUAD | 1 |
p.P175L | SKCM | 1 |
p.R92I | READ | 1 |
p.G221E | SKCM | 1 |
p.G301R | LUAD | 1 |
p.P60H | STAD | 1 |
p.L8I | LUAD | 1 |
p.M306I | HNSC | 1 |
p.V31F | LUAD | 1 |
p.L335F | SKCM | 1 |
p.R128C | STAD | 1 |
p.P206A | COAD | 1 |
p.E229K | SKCM | 1 |
p.F325C | UCEC | 1 |
p.D364H | LUSC | 1 |
p.L327I | LUAD | 1 |
p.G301V | LUAD | 1 |
p.R70H | GBM | 1 |
p.P168S | SKCM | 1 |
p.H349Q | THYM | 1 |
p.A282S | LUAD | 1 |
p.P288S | SKCM | 1 |
p.R133G | HNSC | 1 |
p.L183I | UCEC | 1 |
p.S346L | SKCM | 1 |
p.G211V | LUAD | 1 |
p.S228L | HNSC | 1 |
p.Q279* | BLCA | 1 |
p.L205I | LIHC | 1 |
p.S2C | LUSC | 1 |
p.H34Y | LUSC | 1 |
p.D94Y | LUAD | 1 |
p.Q290X | LIHC | 1 |
p.G338E | SKCM | 1 |
p.W269X | SKCM | 1 |
p.E13A | ESCA | 1 |
p.S203N | LUSC | 1 |
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TissGeneCNV for TIMD4 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TIMD4 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TIMD4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TIMD4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TIMD4 |
TissGeneDrug for TIMD4 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TIMD4 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004096 | Asthma | 4 | BeFree,GAD,LHGDN |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
umls:C0004364 | Autoimmune Diseases | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
umls:C0242339 | Dyslipidemias | 2 | BeFree,GAD |
umls:C2607914 | Allergic rhinitis (disorder) | 2 | BeFree |
umls:C3539909 | Allergic disposition | 2 | BeFree |
umls:C0024534 | Malaria, Cerebral | 1 | GAD |
umls:C0029927 | Ovarian Cysts | 1 | CTD_human |
umls:C0477474 | Dermatitis and eczema | 1 | GAD |