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| TissGeneSummary for SLC16A7 |
 Gene summary |
| Basic gene information | Gene symbol | SLC16A7 |
| Gene name | solute carrier family 16 (monocarboxylate transporter), member 7 | |
| Synonyms | MCT2 | |
| Cytomap | UCSC genome browser: 12q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001270622.1, NM_001270623.1,NM_004731.4,NR_073055.1,NR_073056.1, | |
| Description | monocarboxylate transporter 2solute carrier family 16, member 7 (monocarboxylic acid transporter 2) | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603654 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118596 | ||
| HPRD : 06791 | ||
| Vega : OTTHUMG00000169923 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC16A7 | |
| BioGPS: 9194 | ||
| Pathway | NCI Pathway Interaction Database: SLC16A7 | |
| KEGG: SLC16A7 | ||
| REACTOME: SLC16A7 | ||
| Pathway Commons: SLC16A7 | ||
| Context | iHOP: SLC16A7 | |
| ligand binding site mutation search in PubMed: SLC16A7 | ||
| UCL Cancer Institute: SLC16A7 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTGCT | |
| Reference showing the relevant tissue of SLC16A7 | ||
| Description by TissGene annotations | Risk TissGene in RFS Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:1901475 | pyruvate transmembrane transport | 9786900 | GO:1901475 | pyruvate transmembrane transport | 9786900 |
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| TissGeneExp for SLC16A7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 1.481625233 | 3.098050233 | -1.616425 | 5.35E-06 | 6.80E-05 |
| HNSC | 1.368155175 | 3.51451564 | -2.146360465 | 1.73E-11 | 4.19E-10 |
| BRCA | 0.723209663 | 3.316836856 | -2.593627193 | 3.71E-27 | 4.08E-26 |
| KIRC | 1.909589122 | 5.085972455 | -3.176383333 | 4.94E-37 | 1.65E-35 |
| THCA | -0.923525826 | 0.264002987 | -1.187528814 | 2.63E-08 | 1.24E-07 |
| COAD | -0.270504575 | 0.750003118 | -1.020507692 | 0.01 | 0.021931932 |
| BLCA | 0.801324575 | 2.295935102 | -1.494610526 | 0.00375 | 0.02127551 |
| ESCA | 1.132833188 | 4.944315006 | -3.811481818 | 8.49E-06 | 0.000913862 |
| KIRP | 3.002240858 | 4.434300233 | -1.432059375 | 7.30E-05 | 0.000260615 |
| KICH | 6.200295733 | 4.642407733 | 1.557888 | 7.54E-05 | 0.000202414 |
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| TissGene-miRNA for SLC16A7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-181a-5p | MIMAT0000256 | 0.024 | -0.26 | 78 |
| ACC | hsa-miR-181a-5p | MIMAT0000256 | 0.024 | -0.26 | 78 |
| LUAD | hsa-miR-96-5p | MIMAT0000095 | 0.049 | -0.26 | 60 |
| ACC | hsa-miR-4262 | MIMAT0016894 | 0.018 | -0.27 | 78 |
| ACC | hsa-miR-500b-5p | MIMAT0016925 | 0.016 | -0.27 | 78 |
| ACC | hsa-miR-4262 | MIMAT0016894 | 0.018 | -0.27 | 78 |
| ACC | hsa-miR-500b-5p | MIMAT0016925 | 0.016 | -0.27 | 78 |
| LUAD | hsa-miR-19a-3p | MIMAT0000073 | 0.034 | -0.28 | 60 |
| ACC | hsa-miR-143-3p | MIMAT0000435 | 0.011 | -0.29 | 78 |
| ACC | hsa-miR-143-3p | MIMAT0000435 | 0.011 | -0.29 | 78 |
| ACC | hsa-miR-362-5p | MIMAT0000705 | 0.0063 | -0.31 | 78 |
| ACC | hsa-miR-362-5p | MIMAT0000705 | 0.0063 | -0.31 | 78 |
| LUAD | hsa-miR-33b-5p | MIMAT0003301 | 0.012 | -0.33 | 60 |
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| TissGeneMut for SLC16A7 |
| TissGeneSNV for SLC16A7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F267L | UCEC | 2 |
| p.A146S | LUSC | 1 |
| p.W18C | LUAD | 1 |
| p.G173S | TGCT | 1 |
| p.A146T | STAD | 1 |
| p.T445S | COAD | 1 |
| p.E447* | UCEC | 1 |
| p.Q49H | UCEC | 1 |
| p.R370K | SKCM | 1 |
| p.E402K | PRAD | 1 |
| p.V462I | STAD | 1 |
| p.G253E | SKCM | 1 |
| p.Q443H | HNSC | 1 |
| p.F267L | COAD | 1 |
| p.E447X | COAD | 1 |
| p.G348D | HNSC | 1 |
| p.G72R | UCEC | 1 |
| p.R143X | COAD | 1 |
| p.M289R | BLCA | 1 |
| p.V42I | UCEC | 1 |
| p.A150T | UCEC | 1 |
| p.F139V | DLBC | 1 |
| p.Q129* | UCEC | 1 |
| p.K210R | SKCM | 1 |
| p.G212V | CESC | 1 |
| p.A374V | UCEC | 1 |
| p.E46* | UCS | 1 |
| p.F239L | UCEC | 1 |
| p.D278V | COAD | 1 |
| p.G376X | ESCA | 1 |
| p.K404E | ACC | 1 |
| p.G24E | SKCM | 1 |
| p.L237F | READ | 1 |
| p.Y407H | UCEC | 1 |
| p.G84S | SKCM | 1 |
| p.R312Q | SKCM | 1 |
| p.A131T | PRAD | 1 |
| p.A412T | COAD | 1 |
| p.A269V | BLCA | 1 |
| p.S104Y | BLCA | 1 |
| p.S472L | ESCA | 1 |
| p.S62P | COAD | 1 |
| p.I223V | HNSC | 1 |
| p.Y271C | OV | 1 |
| p.G84D | SKCM | 1 |
| p.S281L | READ | 1 |
| p.G148* | UCEC | 1 |
| p.S104F | SKCM | 1 |
| p.D364Y | LUAD | 1 |
| p.I266L | READ | 1 |
| p.S281L | SKCM | 1 |
| p.R310* | STAD | 1 |
| p.W20C | UCEC | 1 |
| p.A467V | DLBC | 1 |
| p.E435K | SKCM | 1 |
| p.R312* | UCEC | 1 |
| p.R312L | PAAD | 1 |
| p.R310X | STAD | 1 |
| p.P270L | SKCM | 1 |
| p.L342I | HNSC | 1 |
| p.P450R | LUAD | 1 |
| p.G93V | ACC | 1 |
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| TissGeneCNV for SLC16A7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC16A7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1KU-01A | LRIG3-SLC16A7 | In-Frame | chr12:59267836 | chr12:60164999 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1L0-01A | TBC1D15-SLC16A7 | Out-of-Frame | chr12:72266783 | chr12:60164999 |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5KT-01A | WIBG-SLC16A7 | Out-of-Frame | chr12:56297170 | chr12:60173203 |
| Chimerdb3.0 | TopHat-Fusion | SARC | TCGA-DX-A1L0-01A | SLC16A7-NUP107 | 5'UTR-CDS | chr12:59990016 | chr12:69127231 |
| Chimerdb3.0 | TopHat-Fusion | SARC | TCGA-DX-A1L0-01A | SLC16A7-MSRB3 | Out-of-Frame | chr12:60169255 | chr12:65786600 |
| TCGAfusionPortal | PRADA | GBM | TCGA-26-5135-01A | SLC16A7-RP11-362K2.2 | 5UTR-CDS | Chr12:59990017 | Chr12:59206196 |
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| TissGeneNet for SLC16A7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC16A7, UBC, SNTA1, CPEB1 (tumor) | SLC16A7, UBC, SNTA1, CPEB1 (normal) |
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| TissGeneProg for SLC16A7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC16A7 |
| TissGeneDrug for SLC16A7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC16A7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005911 | Body Weight Changes | 1 | GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0018800 | Cardiomegaly | 1 | GAD |
| umls:C0020615 | Hypoglycemia | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
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