![]() |
TissGeneSummary for KCNAB3 |
![]() |
Basic gene information | Gene symbol | KCNAB3 |
Gene name | potassium voltage-gated channel, shaker-related subfamily, beta member 3 | |
Synonyms | AKR6A9|KCNA3.1B|KCNA3B|KV-BETA-3 | |
Cytomap | UCSC genome browser: 17p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_004732.3, | |
Description | K(+) channel subunit beta-3potassium channel, voltage-dependent, beta-3 subunitvoltage-gated potassium channel subunit beta-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604111 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170049 | ||
HPRD : 04983 | ||
Vega : OTTHUMG00000108170 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNAB3 | |
BioGPS: 9196 | ||
Pathway | NCI Pathway Interaction Database: KCNAB3 | |
KEGG: KCNAB3 | ||
REACTOME: KCNAB3 | ||
Pathway Commons: KCNAB3 | ||
Context | iHOP: KCNAB3 | |
ligand binding site mutation search in PubMed: KCNAB3 | ||
UCL Cancer Institute: KCNAB3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | UterusEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | UCEC,UCSUVM | |
Reference showing the relevant tissue of KCNAB3 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for KCNAB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | 0.734393892 | -1.148479792 | 1.882873684 | 0.000581 | 0.004598377 |
Top |
TissGene-miRNA for KCNAB3 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-375 | MIMAT0000728 | 0.0045 | -0.36 | 60 |
Top |
TissGeneMut for KCNAB3 |
TissGeneSNV for KCNAB3 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R299* | LGG | 1 |
p.R174* | UCEC | 1 |
p.R299X | STAD | 1 |
p.R182Q | UCEC | 1 |
p.L93R | SKCM | 1 |
p.G37S | LIHC | 1 |
p.R354C | LGG | 1 |
p.R354H | UCEC | 1 |
p.I156M | BLCA | 1 |
p.R212Q | READ | 1 |
p.I105L | SKCM | 1 |
p.T127I | LUAD | 1 |
p.P203T | BRCA | 1 |
p.S360C | HNSC | 1 |
p.M268I | UCEC | 1 |
p.K159N | UCEC | 1 |
p.E129K | UCEC | 1 |
p.A128S | LUAD | 1 |
p.G341C | UCEC | 1 |
p.P251A | BLCA | 1 |
p.R212Q | STAD | 1 |
p.S173G | STAD | 1 |
p.M390T | SKCM | 1 |
p.E129K | COAD | 1 |
p.T139I | SKCM | 1 |
Top |
TissGeneCNV for KCNAB3 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for KCNAB3 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for KCNAB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for KCNAB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for KCNAB3 |
TissGeneDrug for KCNAB3 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for KCNAB3 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0149931 | Migraine Disorders | 1 | BeFree |