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| TissGeneSummary for CACNA2D2 |
 Gene summary |
| Basic gene information | Gene symbol | CACNA2D2 |
| Gene name | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | |
| Synonyms | CACNA2D | |
| Cytomap | UCSC genome browser: 3p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001005505.2, NM_001174051.2,NM_001291101.1,NM_006030.3, | |
| Description | alpha 2 delta calcium channel subunitgene 26voltage-dependent calcium channel subunit alpha-2/delta-2voltage-gated calcium channel subunit alpha-2/delta-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607082 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000007402 | ||
| HPRD : 06154 | ||
| Vega : OTTHUMG00000156887 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CACNA2D2 | |
| BioGPS: 9254 | ||
| Pathway | NCI Pathway Interaction Database: CACNA2D2 | |
| KEGG: CACNA2D2 | ||
| REACTOME: CACNA2D2 | ||
| Pathway Commons: CACNA2D2 | ||
| Context | iHOP: CACNA2D2 | |
| ligand binding site mutation search in PubMed: CACNA2D2 | ||
| UCL Cancer Institute: CACNA2D2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of CACNA2D2 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CACNA2D2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 2.945874937 | 7.042411144 | -4.096536207 | 4.73E-16 | 5.28E-15 |
| KIRC | -1.194992352 | 1.920328481 | -3.115320833 | 9.35E-44 | 5.11E-42 |
| LUSC | 1.057638122 | 6.859247926 | -5.801609804 | 1.56E-24 | 3.19E-23 |
| HNSC | -1.919138896 | -0.534708664 | -1.384430233 | 4.74E-06 | 2.98E-05 |
| KIRP | -0.532860408 | 2.097836467 | -2.630696875 | 5.02E-14 | 1.08E-12 |
| ESCA | -0.834367226 | 1.994269138 | -2.828636364 | 0.00339 | 0.031045224 |
| COAD | 0.261710746 | 1.516872285 | -1.255161538 | 0.00761 | 0.01736824 |
| STAD | -0.394091658 | 0.905683342 | -1.299775 | 0.000303 | 0.002004256 |
| KICH | 0.175982592 | 1.931942592 | -1.75596 | 0.000347 | 0.000820588 |
| Top |
| TissGene-miRNA for CACNA2D2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-181d-5p | MIMAT0002821 | 0.043 | -0.26 | 60 |
| LUAD | hsa-miR-34c-5p | MIMAT0000686 | 0.0075 | -0.34 | 60 |
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| TissGeneMut for CACNA2D2 |
| TissGeneSNV for CACNA2D2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R102Q | SKCM | 2 |
| p.R736C | COAD | 2 |
| p.R239H | STAD | 2 |
| p.G501E | SKCM | 1 |
| p.D694N | SKCM | 1 |
| p.N854K | BRCA | 1 |
| p.S1039F | LUSC | 1 |
| p.K706E | ESCA | 1 |
| p.T576N | UCEC | 1 |
| p.S204L | SKCM | 1 |
| p.S427Y | THYM | 1 |
| p.E780K | THYM | 1 |
| p.R266Q | SKCM | 1 |
| p.E996K | BRCA | 1 |
| p.G599V | BRCA | 1 |
| p.E882K | SKCM | 1 |
| p.V91I | UCEC | 1 |
| p.R835C | PRAD | 1 |
| p.V410I | COAD | 1 |
| p.S182Y | UCEC | 1 |
| p.V640G | BRCA | 1 |
| p.E1003A | MESO | 1 |
| p.P211S | SKCM | 1 |
| p.N445I | STAD | 1 |
| p.G764S | GBM | 1 |
| p.G90S | SKCM | 1 |
| p.N199Y | UCEC | 1 |
| p.R86Q | SKCM | 1 |
| p.D873N | SKCM | 1 |
| p.I983V | COAD | 1 |
| p.E106D | BLCA | 1 |
| p.D581N | SKCM | 1 |
| p.G83D | SKCM | 1 |
| p.R422C | UCEC | 1 |
| p.K165E | THYM | 1 |
| p.D742N | UCEC | 1 |
| p.D405G | STAD | 1 |
| p.E875K | SKCM | 1 |
| p.R258L | STAD | 1 |
| p.M395I | SKCM | 1 |
| p.R862H | LIHC | 1 |
| p.S427F | SKCM | 1 |
| p.D880N | SKCM | 1 |
| p.G764S | SKCM | 1 |
| p.Y1094C | PRAD | 1 |
| p.E1010D | BLCA | 1 |
| p.R258C | UCEC | 1 |
| p.E886Q | LUSC | 1 |
| p.V364M | SKCM | 1 |
| p.E683K | SKCM | 1 |
| p.N1105K | BLCA | 1 |
| p.R743H | DLBC | 1 |
| p.E109* | BLCA | 1 |
| p.N1102K | BLCA | 1 |
| p.D167N | UCEC | 1 |
| p.E679Q | CESC | 1 |
| p.L922P | BLCA | 1 |
| p.V883A | SKCM | 1 |
| p.T626A | STAD | 1 |
| p.F144Y | SKCM | 1 |
| p.D711N | UCEC | 1 |
| p.V524M | BLCA | 1 |
| p.R811K | CESC | 1 |
| p.R934C | STAD | 1 |
| p.F550L | COAD | 1 |
| p.L522M | COAD | 1 |
| p.E316K | SKCM | 1 |
| p.G757S | SKCM | 1 |
| p.N110Y | SKCM | 1 |
| p.G494R | SKCM | 1 |
| p.A845V | SKCM | 1 |
| p.R351H | COAD | 1 |
| p.E587K | HNSC | 1 |
| p.D533E | GBM | 1 |
| p.G477D | LIHC | 1 |
| p.V428M | KIRP | 1 |
| p.A852V | SKCM | 1 |
| p.F191V | SKCM | 1 |
| p.N903S | LUSC | 1 |
| p.V677I | LGG | 1 |
| p.H797Y | HNSC | 1 |
| p.S303G | LIHC | 1 |
| p.R792H | CESC | 1 |
| p.R1143C | UCEC | 1 |
| p.E179K | SKCM | 1 |
| p.M397V | COAD | 1 |
| p.A760T | STAD | 1 |
| p.R406S | LIHC | 1 |
| p.R934C | LIHC | 1 |
| p.D190Y | PRAD | 1 |
| p.E591Q | HNSC | 1 |
| Top |
| TissGeneCNV for CACNA2D2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CACNA2D2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI655740 | CACNA2D2-CACNA2D2 | chr3:50404031 | chr3:50404835 | |
| Chimerdb3.0 | ChiTaRs | NA | BF085098 | CACNA2D2-SLCO4A1 | chr3:50404910 | chr20:61282331 | |
| TCGAfusionPortal | PRADA | BLCA | TCGA-FD-A3SJ-01A | RHOA-CACNA2D2 | 5UTR-CDS | Chr3:49449253 | Chr3:50431599 |
| TCGAfusionPortal | PRADA | SKCM | TCGA-ER-A19T-01A | CACNA2D2-THRSP | CDS-3UTR | Chr3:50540649 | Chr11:77778705 |
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| TissGeneNet for CACNA2D2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| CACNA2D2, HNF4A (tumor) | CACNA2D2, HNF4A (normal) |
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| TissGeneProg for CACNA2D2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for CACNA2D2 |
| TissGeneDrug for CACNA2D2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CACNA2D2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014553 | Absence Epilepsy | 2 | BeFree,CTD_human |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0004134 | Ataxia | 1 | CTD_human |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007758 | Cerebellar Ataxia | 1 | LHGDN |
| umls:C0008489 | Chorea | 1 | CTD_human |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0021361 | Female infertility | 1 | CTD_human |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0543888 | Epileptic encephalopathy | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0878500 | Intraepithelial Neoplasia | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
| umls:C2750893 | EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 11 | 0 | MGD |
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