TissGeneSummary for PIWIL1 |
Gene summary |
Basic gene information | Gene symbol | PIWIL1 |
Gene name | piwi-like RNA-mediated gene silencing 1 | |
Synonyms | CT80.1|HIWI|MIWI|PIWI | |
Cytomap | UCSC genome browser: 12q24.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001190971.1, NM_004764.4, | |
Description | piwi homologpiwi-like protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605571 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125207 | ||
HPRD : 10409 | ||
Vega : OTTHUMG00000168382 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PIWIL1 | |
BioGPS: 9271 | ||
Pathway | NCI Pathway Interaction Database: PIWIL1 | |
KEGG: PIWIL1 | ||
REACTOME: PIWIL1 | ||
Pathway Commons: PIWIL1 | ||
Context | iHOP: PIWIL1 | |
ligand binding site mutation search in PubMed: PIWIL1 | ||
UCL Cancer Institute: PIWIL1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PIWIL1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PIWIL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.709272457 | 0.313047543 | -2.02232 | 1.72E-08 | 8.82E-08 |
THCA | 3.48383439 | 1.161742865 | 2.322091525 | 1.28E-08 | 6.28E-08 |
KIRP | -2.151985207 | -0.227232082 | -1.924753125 | 3.39E-13 | 5.98E-12 |
STAD | 1.710505418 | -2.177860207 | 3.888365625 | 2.12E-07 | 4.92E-06 |
COAD | 2.202364312 | -1.421377996 | 3.623742308 | 7.79E-06 | 3.67E-05 |
KIRC | -1.417490068 | -0.329992846 | -1.087497222 | 5.71E-11 | 2.08E-10 |
ESCA | 1.024528997 | -2.138071003 | 3.1626 | 0.00506 | 0.039764806 |
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TissGene-miRNA for PIWIL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PIWIL1 |
TissGeneSNV for PIWIL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R230Q | UCEC | 2 |
p.D702N | BLCA | 2 |
p.R502Q | SKCM | 2 |
p.K294T | UCEC | 2 |
p.V699M | SKCM | 1 |
p.R217K | SKCM | 1 |
p.R217S | THYM | 1 |
p.G54E | SKCM | 1 |
p.R230* | BLCA | 1 |
p.P831A | BRCA | 1 |
p.P41T | LUSC | 1 |
p.H429Y | BLCA | 1 |
p.T792K | SKCM | 1 |
p.Q751H | PRAD | 1 |
p.R439G | OV | 1 |
p.V699M | DLBC | 1 |
p.R502* | LUAD | 1 |
p.Y212* | LUAD | 1 |
p.V340A | STAD | 1 |
p.S75L | SKCM | 1 |
p.N800H | SKCM | 1 |
p.Q751* | BLCA | 1 |
p.P203H | HNSC | 1 |
p.K548N | THYM | 1 |
p.Q72* | SKCM | 1 |
p.R537K | SKCM | 1 |
p.R230Q | SKCM | 1 |
p.M608I | SKCM | 1 |
p.R6Q | SKCM | 1 |
p.R810C | DLBC | 1 |
p.G165* | SKCM | 1 |
p.K294N | READ | 1 |
p.R543K | LUAD | 1 |
p.F119L | LUAD | 1 |
p.S243C | LUSC | 1 |
p.C387F | LUAD | 1 |
p.R275Q | BLCA | 1 |
p.E154K | UCEC | 1 |
p.L150I | LUSC | 1 |
p.E78K | ACC | 1 |
p.Q352K | LUSC | 1 |
p.S479F | SKCM | 1 |
p.A681V | UCEC | 1 |
p.R14H | READ | 1 |
p.D432N | UCEC | 1 |
p.R82C | PRAD | 1 |
p.D632N | SARC | 1 |
p.R82C | READ | 1 |
p.E302X | READ | 1 |
p.G484C | PRAD | 1 |
p.R275Q | COAD | 1 |
p.R83H | COAD | 1 |
p.A570T | ESCA | 1 |
p.D325N | BRCA | 1 |
p.K301E | BRCA | 1 |
p.D632N | UCEC | 1 |
p.D405Y | READ | 1 |
p.D766N | SARC | 1 |
p.D440E | LUSC | 1 |
p.D578E | PRAD | 1 |
p.R423* | PRAD | 1 |
p.Q296* | SKCM | 1 |
p.P831S | SKCM | 1 |
p.Q34* | LUAD | 1 |
p.G674E | UCEC | 1 |
p.V699M | HNSC | 1 |
p.R347K | SKCM | 1 |
p.M693I | KIRC | 1 |
p.R423X | PRAD | 1 |
p.L854P | CESC | 1 |
p.L343S | LIHC | 1 |
p.L150I | ESCA | 1 |
p.A835S | STAD | 1 |
p.R439Q | HNSC | 1 |
p.S62* | LUSC | 1 |
p.G337C | THYM | 1 |
p.D552Y | COAD | 1 |
p.E481* | UCEC | 1 |
p.G70E | PRAD | 1 |
p.Q52H | LIHC | 1 |
p.M522I | THYM | 1 |
p.K315N | SARC | 1 |
p.Q547* | CESC | 1 |
p.G373V | LUAD | 1 |
p.R439Q | LUAD | 1 |
p.T196N | HNSC | 1 |
p.Y541H | UCEC | 1 |
p.G3E | BRCA | 1 |
p.K294T | READ | 1 |
p.N96H | SKCM | 1 |
p.R827C | SKCM | 1 |
p.D799G | UCEC | 1 |
p.W441* | LUSC | 1 |
p.E344D | PAAD | 1 |
p.D268G | ESCA | 1 |
p.M283L | LUAD | 1 |
p.V490F | LUAD | 1 |
p.E45V | HNSC | 1 |
p.A380G | BLCA | 1 |
p.K329N | UCEC | 1 |
p.W496* | HNSC | 1 |
p.F211I | OV | 1 |
p.A681_splice | UCEC | 1 |
p.R230L | CHOL | 1 |
p.P473L | SKCM | 1 |
p.E716K | UCS | 1 |
p.G70E | COAD | 1 |
p.G654E | SKCM | 1 |
p.Q289X | COAD | 1 |
p.D578N | SKCM | 1 |
p.A835T | COAD | 1 |
p.F748L | HNSC | 1 |
p.G31V | LUAD | 1 |
p.R419H | BRCA | 1 |
p.K177N | UCEC | 1 |
p.Q607H | LUSC | 1 |
p.Y471X | STAD | 1 |
p.Q38* | CESC | 1 |
p.Y794S | UCEC | 1 |
p.K461Q | UCEC | 1 |
p.R275* | BRCA | 1 |
p.R217M | LUAD | 1 |
p.S827P | THYM | 1 |
p.R455K | SKCM | 1 |
p.W822L | ESCA | 1 |
p.H463Y | SKCM | 1 |
p.A783V | SKCM | 1 |
p.A540T | SKCM | 1 |
p.G646R | SKCM | 1 |
p.D722N | SKCM | 1 |
p.K567E | STAD | 1 |
p.Q131* | SKCM | 1 |
p.P694H | LUAD | 1 |
p.R502Q | GBM | 1 |
p.R657H | COAD | 1 |
p.R661C | BRCA | 1 |
p.V717A | LIHC | 1 |
p.V490A | READ | 1 |
p.L542S | COAD | 1 |
p.F252I | LUAD | 1 |
p.E297Q | HNSC | 1 |
p.D240Y | LUAD | 1 |
p.R14H | BRCA | 1 |
p.T590N | KIRC | 1 |
p.Y471* | STAD | 1 |
p.T736M | READ | 1 |
p.A645T | STAD | 1 |
p.A588V | ESCA | 1 |
p.Q72X | SKCM | 1 |
p.E200K | SKCM | 1 |
p.Q131X | SKCM | 1 |
p.K467* | SKCM | 1 |
p.R124H | GBM | 1 |
p.E102K | UCEC | 1 |
p.R537I | UCEC | 1 |
p.H118N | SARC | 1 |
p.G165X | SKCM | 1 |
p.G613X | THYM | 1 |
p.R397H | ESCA | 1 |
p.R641W | UCEC | 1 |
p.C160* | BLCA | 1 |
p.M522I | LUAD | 1 |
p.G465D | BLCA | 1 |
p.E533K | SKCM | 1 |
p.A335T | UCEC | 1 |
p.N448K | PRAD | 1 |
p.R397H | COAD | 1 |
p.R51W | PAAD | 1 |
p.S330N | BLCA | 1 |
p.K548E | LIHC | 1 |
p.L841F | SKCM | 1 |
p.R667K | SKCM | 1 |
p.E154K | SKCM | 1 |
p.A521V | SKCM | 1 |
p.R641W | BLCA | 1 |
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TissGeneCNV for PIWIL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PIWIL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PIWIL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PIWIL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PIWIL1 |
TissGeneDrug for PIWIL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PIWIL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 9 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree,GAD |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
umls:C0684249 | Carcinoma of lung | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0022665 | Kidney Neoplasm | 2 | GAD |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0011065 | Cessation of life | 1 | LHGDN |
umls:C0019163 | Hepatitis B | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0036631 | Seminoma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0086692 | Benign Neoplasm | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0236969 | Substance-Related Disorders | 1 | CTD_human |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C0855197 | Testicular malignant germ cell tumor | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | LHGDN |