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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PIWIL1
check button Gene summary
Basic gene informationGene symbolPIWIL1
Gene namepiwi-like RNA-mediated gene silencing 1
SynonymsCT80.1|HIWI|MIWI|PIWI
CytomapUCSC genome browser: 12q24.33
Type of geneprotein-coding
RefGenesNM_001190971.1,
NM_004764.4,
Descriptionpiwi homologpiwi-like protein 1
Modification date20141207
dbXrefs MIM : 605571
HGNC : HGNC
Ensembl : ENSG00000125207
HPRD : 10409
Vega : OTTHUMG00000168382
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PIWIL1
BioGPS: 9271
PathwayNCI Pathway Interaction Database: PIWIL1
KEGG: PIWIL1
REACTOME: PIWIL1
Pathway Commons: PIWIL1
ContextiHOP: PIWIL1
ligand binding site mutation search in PubMed: PIWIL1
UCL Cancer Institute: PIWIL1
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of PIWIL1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PIWIL1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.7092724570.313047543-2.022321.72E-088.82E-08
THCA3.483834391.1617428652.3220915251.28E-086.28E-08
KIRP-2.151985207-0.227232082-1.9247531253.39E-135.98E-12
STAD1.710505418-2.1778602073.8883656252.12E-074.92E-06
COAD2.202364312-1.4213779963.6237423087.79E-063.67E-05
KIRC-1.417490068-0.329992846-1.0874972225.71E-112.08E-10
ESCA1.024528997-2.1380710033.16260.005060.039764806


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TissGene-miRNA for PIWIL1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PIWIL1
TissGeneSNV for PIWIL1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R230QUCEC2
p.D702NBLCA2
p.R502QSKCM2
p.K294TUCEC2
p.V699MSKCM1
p.R217KSKCM1
p.R217STHYM1
p.G54ESKCM1
p.R230*BLCA1
p.P831ABRCA1
p.P41TLUSC1
p.H429YBLCA1
p.T792KSKCM1
p.Q751HPRAD1
p.R439GOV1
p.V699MDLBC1
p.R502*LUAD1
p.Y212*LUAD1
p.V340ASTAD1
p.S75LSKCM1
p.N800HSKCM1
p.Q751*BLCA1
p.P203HHNSC1
p.K548NTHYM1
p.Q72*SKCM1
p.R537KSKCM1
p.R230QSKCM1
p.M608ISKCM1
p.R6QSKCM1
p.R810CDLBC1
p.G165*SKCM1
p.K294NREAD1
p.R543KLUAD1
p.F119LLUAD1
p.S243CLUSC1
p.C387FLUAD1
p.R275QBLCA1
p.E154KUCEC1
p.L150ILUSC1
p.E78KACC1
p.Q352KLUSC1
p.S479FSKCM1
p.A681VUCEC1
p.R14HREAD1
p.D432NUCEC1
p.R82CPRAD1
p.D632NSARC1
p.R82CREAD1
p.E302XREAD1
p.G484CPRAD1
p.R275QCOAD1
p.R83HCOAD1
p.A570TESCA1
p.D325NBRCA1
p.K301EBRCA1
p.D632NUCEC1
p.D405YREAD1
p.D766NSARC1
p.D440ELUSC1
p.D578EPRAD1
p.R423*PRAD1
p.Q296*SKCM1
p.P831SSKCM1
p.Q34*LUAD1
p.G674EUCEC1
p.V699MHNSC1
p.R347KSKCM1
p.M693IKIRC1
p.R423XPRAD1
p.L854PCESC1
p.L343SLIHC1
p.L150IESCA1
p.A835SSTAD1
p.R439QHNSC1
p.S62*LUSC1
p.G337CTHYM1
p.D552YCOAD1
p.E481*UCEC1
p.G70EPRAD1
p.Q52HLIHC1
p.M522ITHYM1
p.K315NSARC1
p.Q547*CESC1
p.G373VLUAD1
p.R439QLUAD1
p.T196NHNSC1
p.Y541HUCEC1
p.G3EBRCA1
p.K294TREAD1
p.N96HSKCM1
p.R827CSKCM1
p.D799GUCEC1
p.W441*LUSC1
p.E344DPAAD1
p.D268GESCA1
p.M283LLUAD1
p.V490FLUAD1
p.E45VHNSC1
p.A380GBLCA1
p.K329NUCEC1
p.W496*HNSC1
p.F211IOV1
p.A681_spliceUCEC1
p.R230LCHOL1
p.P473LSKCM1
p.E716KUCS1
p.G70ECOAD1
p.G654ESKCM1
p.Q289XCOAD1
p.D578NSKCM1
p.A835TCOAD1
p.F748LHNSC1
p.G31VLUAD1
p.R419HBRCA1
p.K177NUCEC1
p.Q607HLUSC1
p.Y471XSTAD1
p.Q38*CESC1
p.Y794SUCEC1
p.K461QUCEC1
p.R275*BRCA1
p.R217MLUAD1
p.S827PTHYM1
p.R455KSKCM1
p.W822LESCA1
p.H463YSKCM1
p.A783VSKCM1
p.A540TSKCM1
p.G646RSKCM1
p.D722NSKCM1
p.K567ESTAD1
p.Q131*SKCM1
p.P694HLUAD1
p.R502QGBM1
p.R657HCOAD1
p.R661CBRCA1
p.V717ALIHC1
p.V490AREAD1
p.L542SCOAD1
p.F252ILUAD1
p.E297QHNSC1
p.D240YLUAD1
p.R14HBRCA1
p.T590NKIRC1
p.Y471*STAD1
p.T736MREAD1
p.A645TSTAD1
p.A588VESCA1
p.Q72XSKCM1
p.E200KSKCM1
p.Q131XSKCM1
p.K467*SKCM1
p.R124HGBM1
p.E102KUCEC1
p.R537IUCEC1
p.H118NSARC1
p.G165XSKCM1
p.G613XTHYM1
p.R397HESCA1
p.R641WUCEC1
p.C160*BLCA1
p.M522ILUAD1
p.G465DBLCA1
p.E533KSKCM1
p.A335TUCEC1
p.N448KPRAD1
p.R397HCOAD1
p.R51WPAAD1
p.S330NBLCA1
p.K548ELIHC1
p.L841FSKCM1
p.R667KSKCM1
p.E154KSKCM1
p.A521VSKCM1
p.R641WBLCA1


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TissGeneCNV for PIWIL1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PIWIL1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for PIWIL1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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COAD (tumor)COAD (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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HNSC (tumor)HNSC (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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KICH (tumor)KICH (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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KIRC (tumor)KIRC (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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KIRP (tumor)KIRP (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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LIHC (tumor)LIHC (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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LUAD (tumor)LUAD (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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LUSC (tumor)LUSC (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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PRAD (tumor)PRAD (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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STAD (tumor)STAD (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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THCA (tumor)THCA (normal)
PIWIL1, TP53, TP63, TP73, DICER1 (tumor)PIWIL1, TP53, TP63, TP73, DICER1 (normal)
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TissGeneProg for PIWIL1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PIWIL1
TissGeneDrug for PIWIL1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PIWIL1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0596263Carcinogenesis9BeFree
umls:C0007134Renal Cell Carcinoma3BeFree,GAD
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007103Malignant neoplasm of endometrium2BeFree
umls:C0017638Glioma2BeFree
umls:C0022665Kidney Neoplasm2GAD
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C1883486Uterine Corpus Cancer2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0004509Azoospermia1GAD
umls:C0011065Cessation of life1LHGDN
umls:C0019163Hepatitis B1BeFree
umls:C0021364Male infertility1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0028960Oligospermia1GAD
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0036631Seminoma1BeFree
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0086692Benign Neoplasm1BeFree
umls:C0153594Malignant neoplasm of testis1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0236969Substance-Related Disorders1CTD_human
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0546837Malignant neoplasm of esophagus1GAD
umls:C0699791Stomach Carcinoma1BeFree
umls:C0855197Testicular malignant germ cell tumor1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1261473Sarcoma1LHGDN