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| TissGeneSummary for PIWIL1 |
 Gene summary |
| Basic gene information | Gene symbol | PIWIL1 |
| Gene name | piwi-like RNA-mediated gene silencing 1 | |
| Synonyms | CT80.1|HIWI|MIWI|PIWI | |
| Cytomap | UCSC genome browser: 12q24.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001190971.1, NM_004764.4, | |
| Description | piwi homologpiwi-like protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605571 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125207 | ||
| HPRD : 10409 | ||
| Vega : OTTHUMG00000168382 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIWIL1 | |
| BioGPS: 9271 | ||
| Pathway | NCI Pathway Interaction Database: PIWIL1 | |
| KEGG: PIWIL1 | ||
| REACTOME: PIWIL1 | ||
| Pathway Commons: PIWIL1 | ||
| Context | iHOP: PIWIL1 | |
| ligand binding site mutation search in PubMed: PIWIL1 | ||
| UCL Cancer Institute: PIWIL1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of PIWIL1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PIWIL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.709272457 | 0.313047543 | -2.02232 | 1.72E-08 | 8.82E-08 |
| THCA | 3.48383439 | 1.161742865 | 2.322091525 | 1.28E-08 | 6.28E-08 |
| KIRP | -2.151985207 | -0.227232082 | -1.924753125 | 3.39E-13 | 5.98E-12 |
| STAD | 1.710505418 | -2.177860207 | 3.888365625 | 2.12E-07 | 4.92E-06 |
| COAD | 2.202364312 | -1.421377996 | 3.623742308 | 7.79E-06 | 3.67E-05 |
| KIRC | -1.417490068 | -0.329992846 | -1.087497222 | 5.71E-11 | 2.08E-10 |
| ESCA | 1.024528997 | -2.138071003 | 3.1626 | 0.00506 | 0.039764806 |
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| TissGene-miRNA for PIWIL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PIWIL1 |
| TissGeneSNV for PIWIL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R230Q | UCEC | 2 |
| p.D702N | BLCA | 2 |
| p.R502Q | SKCM | 2 |
| p.K294T | UCEC | 2 |
| p.V699M | SKCM | 1 |
| p.R217K | SKCM | 1 |
| p.R217S | THYM | 1 |
| p.G54E | SKCM | 1 |
| p.R230* | BLCA | 1 |
| p.P831A | BRCA | 1 |
| p.P41T | LUSC | 1 |
| p.H429Y | BLCA | 1 |
| p.T792K | SKCM | 1 |
| p.Q751H | PRAD | 1 |
| p.R439G | OV | 1 |
| p.V699M | DLBC | 1 |
| p.R502* | LUAD | 1 |
| p.Y212* | LUAD | 1 |
| p.V340A | STAD | 1 |
| p.S75L | SKCM | 1 |
| p.N800H | SKCM | 1 |
| p.Q751* | BLCA | 1 |
| p.P203H | HNSC | 1 |
| p.K548N | THYM | 1 |
| p.Q72* | SKCM | 1 |
| p.R537K | SKCM | 1 |
| p.R230Q | SKCM | 1 |
| p.M608I | SKCM | 1 |
| p.R6Q | SKCM | 1 |
| p.R810C | DLBC | 1 |
| p.G165* | SKCM | 1 |
| p.K294N | READ | 1 |
| p.R543K | LUAD | 1 |
| p.F119L | LUAD | 1 |
| p.S243C | LUSC | 1 |
| p.C387F | LUAD | 1 |
| p.R275Q | BLCA | 1 |
| p.E154K | UCEC | 1 |
| p.L150I | LUSC | 1 |
| p.E78K | ACC | 1 |
| p.Q352K | LUSC | 1 |
| p.S479F | SKCM | 1 |
| p.A681V | UCEC | 1 |
| p.R14H | READ | 1 |
| p.D432N | UCEC | 1 |
| p.R82C | PRAD | 1 |
| p.D632N | SARC | 1 |
| p.R82C | READ | 1 |
| p.E302X | READ | 1 |
| p.G484C | PRAD | 1 |
| p.R275Q | COAD | 1 |
| p.R83H | COAD | 1 |
| p.A570T | ESCA | 1 |
| p.D325N | BRCA | 1 |
| p.K301E | BRCA | 1 |
| p.D632N | UCEC | 1 |
| p.D405Y | READ | 1 |
| p.D766N | SARC | 1 |
| p.D440E | LUSC | 1 |
| p.D578E | PRAD | 1 |
| p.R423* | PRAD | 1 |
| p.Q296* | SKCM | 1 |
| p.P831S | SKCM | 1 |
| p.Q34* | LUAD | 1 |
| p.G674E | UCEC | 1 |
| p.V699M | HNSC | 1 |
| p.R347K | SKCM | 1 |
| p.M693I | KIRC | 1 |
| p.R423X | PRAD | 1 |
| p.L854P | CESC | 1 |
| p.L343S | LIHC | 1 |
| p.L150I | ESCA | 1 |
| p.A835S | STAD | 1 |
| p.R439Q | HNSC | 1 |
| p.S62* | LUSC | 1 |
| p.G337C | THYM | 1 |
| p.D552Y | COAD | 1 |
| p.E481* | UCEC | 1 |
| p.G70E | PRAD | 1 |
| p.Q52H | LIHC | 1 |
| p.M522I | THYM | 1 |
| p.K315N | SARC | 1 |
| p.Q547* | CESC | 1 |
| p.G373V | LUAD | 1 |
| p.R439Q | LUAD | 1 |
| p.T196N | HNSC | 1 |
| p.Y541H | UCEC | 1 |
| p.G3E | BRCA | 1 |
| p.K294T | READ | 1 |
| p.N96H | SKCM | 1 |
| p.R827C | SKCM | 1 |
| p.D799G | UCEC | 1 |
| p.W441* | LUSC | 1 |
| p.E344D | PAAD | 1 |
| p.D268G | ESCA | 1 |
| p.M283L | LUAD | 1 |
| p.V490F | LUAD | 1 |
| p.E45V | HNSC | 1 |
| p.A380G | BLCA | 1 |
| p.K329N | UCEC | 1 |
| p.W496* | HNSC | 1 |
| p.F211I | OV | 1 |
| p.A681_splice | UCEC | 1 |
| p.R230L | CHOL | 1 |
| p.P473L | SKCM | 1 |
| p.E716K | UCS | 1 |
| p.G70E | COAD | 1 |
| p.G654E | SKCM | 1 |
| p.Q289X | COAD | 1 |
| p.D578N | SKCM | 1 |
| p.A835T | COAD | 1 |
| p.F748L | HNSC | 1 |
| p.G31V | LUAD | 1 |
| p.R419H | BRCA | 1 |
| p.K177N | UCEC | 1 |
| p.Q607H | LUSC | 1 |
| p.Y471X | STAD | 1 |
| p.Q38* | CESC | 1 |
| p.Y794S | UCEC | 1 |
| p.K461Q | UCEC | 1 |
| p.R275* | BRCA | 1 |
| p.R217M | LUAD | 1 |
| p.S827P | THYM | 1 |
| p.R455K | SKCM | 1 |
| p.W822L | ESCA | 1 |
| p.H463Y | SKCM | 1 |
| p.A783V | SKCM | 1 |
| p.A540T | SKCM | 1 |
| p.G646R | SKCM | 1 |
| p.D722N | SKCM | 1 |
| p.K567E | STAD | 1 |
| p.Q131* | SKCM | 1 |
| p.P694H | LUAD | 1 |
| p.R502Q | GBM | 1 |
| p.R657H | COAD | 1 |
| p.R661C | BRCA | 1 |
| p.V717A | LIHC | 1 |
| p.V490A | READ | 1 |
| p.L542S | COAD | 1 |
| p.F252I | LUAD | 1 |
| p.E297Q | HNSC | 1 |
| p.D240Y | LUAD | 1 |
| p.R14H | BRCA | 1 |
| p.T590N | KIRC | 1 |
| p.Y471* | STAD | 1 |
| p.T736M | READ | 1 |
| p.A645T | STAD | 1 |
| p.A588V | ESCA | 1 |
| p.Q72X | SKCM | 1 |
| p.E200K | SKCM | 1 |
| p.Q131X | SKCM | 1 |
| p.K467* | SKCM | 1 |
| p.R124H | GBM | 1 |
| p.E102K | UCEC | 1 |
| p.R537I | UCEC | 1 |
| p.H118N | SARC | 1 |
| p.G165X | SKCM | 1 |
| p.G613X | THYM | 1 |
| p.R397H | ESCA | 1 |
| p.R641W | UCEC | 1 |
| p.C160* | BLCA | 1 |
| p.M522I | LUAD | 1 |
| p.G465D | BLCA | 1 |
| p.E533K | SKCM | 1 |
| p.A335T | UCEC | 1 |
| p.N448K | PRAD | 1 |
| p.R397H | COAD | 1 |
| p.R51W | PAAD | 1 |
| p.S330N | BLCA | 1 |
| p.K548E | LIHC | 1 |
| p.L841F | SKCM | 1 |
| p.R667K | SKCM | 1 |
| p.E154K | SKCM | 1 |
| p.A521V | SKCM | 1 |
| p.R641W | BLCA | 1 |
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| TissGeneCNV for PIWIL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PIWIL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PIWIL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
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| COAD (tumor) | COAD (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
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| KICH (tumor) | KICH (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PIWIL1, TP53, TP63, TP73, DICER1 (tumor) | PIWIL1, TP53, TP63, TP73, DICER1 (normal) |
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| TissGeneProg for PIWIL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PIWIL1 |
| TissGeneDrug for PIWIL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PIWIL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 9 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0022665 | Kidney Neoplasm | 2 | GAD |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0004509 | Azoospermia | 1 | GAD |
| umls:C0011065 | Cessation of life | 1 | LHGDN |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0028960 | Oligospermia | 1 | GAD |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | CTD_human |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0855197 | Testicular malignant germ cell tumor | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | LHGDN |
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