TissGeneSummary for GPR37L1 |
Gene summary |
Basic gene information | Gene symbol | GPR37L1 |
Gene name | G protein-coupled receptor 37 like 1 | |
Synonyms | ET(B)R-LP-2|ETBR-LP-2 | |
Cytomap | UCSC genome browser: 1q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_004767.3, | |
Description | G-protein coupled receptor 37 like 1G-protein coupled receptor 37-like 1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2prosaposin receptor GPR37L1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 13603 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GPR37L1 | |
BioGPS: 9283 | ||
Pathway | NCI Pathway Interaction Database: GPR37L1 | |
KEGG: GPR37L1 | ||
REACTOME: GPR37L1 | ||
Pathway Commons: GPR37L1 | ||
Context | iHOP: GPR37L1 | |
ligand binding site mutation search in PubMed: GPR37L1 | ||
UCL Cancer Institute: GPR37L1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of GPR37L1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 23690594 | GO:0043410 | positive regulation of MAPK cascade | 23690594 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 23690594 | GO:0043410 | positive regulation of MAPK cascade | 23690594 |
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TissGeneExp for GPR37L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.310869359 | -2.628502693 | 1.317633333 | 3.68E-07 | 9.65E-07 |
LUAD | -1.964306073 | -3.039223315 | 1.074917241 | 2.20E-06 | 6.93E-06 |
BRCA | -1.478846243 | -2.563907646 | 1.085061404 | 1.24E-08 | 4.03E-08 |
PRAD | -2.682235649 | -1.554560649 | -1.127675 | 4.53E-07 | 3.48E-06 |
COAD | 0.043914351 | 1.307533582 | -1.263619231 | 5.79E-07 | 3.42E-06 |
THCA | -2.521324893 | -0.7517893 | -1.769535593 | 3.27E-13 | 3.20E-12 |
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TissGene-miRNA for GPR37L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-1306-5p | MIMAT0022726 | 0.023 | -0.31 | 56 |
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TissGeneMut for GPR37L1 |
TissGeneSNV for GPR37L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T261M | STAD | 2 |
p.P237L | SKCM | 1 |
p.S150L | HNSC | 1 |
p.W5* | SKCM | 1 |
p.V366M | STAD | 1 |
p.T124I | LUSC | 1 |
p.I411V | LGG | 1 |
p.V143E | SKCM | 1 |
p.D395N | SKCM | 1 |
p.G144C | KIRC | 1 |
p.P81A | COAD | 1 |
p.V367I | LIHC | 1 |
p.R391S | SKCM | 1 |
p.T372I | HNSC | 1 |
p.L236M | STAD | 1 |
p.I133T | STAD | 1 |
p.E36K | COAD | 1 |
p.G90S | ESCA | 1 |
p.P96L | SKCM | 1 |
p.I322L | SKCM | 1 |
p.T412I | SKCM | 1 |
p.V366L | ESCA | 1 |
p.P78A | HNSC | 1 |
p.G398S | SKCM | 1 |
p.C286Y | BLCA | 1 |
p.P68L | PRAD | 1 |
p.S127C | BLCA | 1 |
p.E125K | UCEC | 1 |
p.P278T | STAD | 1 |
p.S213F | BLCA | 1 |
p.W5X | SKCM | 1 |
p.V366M | COAD | 1 |
p.A308T | UCEC | 1 |
p.Q115H | UCEC | 1 |
p.A410T | COAD | 1 |
p.L224M | PRAD | 1 |
p.V335G | BLCA | 1 |
p.S234N | UCEC | 1 |
p.R309C | HNSC | 1 |
p.L178V | BLCA | 1 |
p.Y67N | LUSC | 1 |
p.L397M | STAD | 1 |
p.E275A | UCEC | 1 |
p.R228H | HNSC | 1 |
p.C434* | SKCM | 1 |
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TissGeneCNV for GPR37L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GPR37L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI884619 | GPR37L1-PLXNB3 | chr1:202098634 | chrX:153041811 | |
Chimerdb3.0 | ChiTaRs | NA | AI886978 | GPR37L1-PLXNB3 | chr1:202098634 | chrX:153043019 | |
Chimerdb3.0 | FusionScan | OV | TCGA-VG-A8LO-01A | LGR6-GPR37L1 | Out-of-Frame | chr1:202205121 | chr1:202096868 |
Chimerdb3.0 | FusionScan | OV | TCGA-3P-A9WA-01A | LGR6-GPR37L1 | Out-of-Frame | chr1:202205121 | chr1:202096868 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A124-01A | TESK2-GPR37L1 | In-frame | Chr1:45923236 | Chr1:202096869 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0AV-01A | LGR6-GPR37L1 | Out-of-frame | Chr1:202163329 | Chr1:202096869 |
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TissGeneNet for GPR37L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GPR37L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GPR37L1 |
TissGeneDrug for GPR37L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GPR37L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018799 | Heart Diseases | 1 | GAD |
umls:C0085298 | Sudden Cardiac Death | 1 | GAD |