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| TissGeneSummary for MS4A3 |
 Gene summary |
| Basic gene information | Gene symbol | MS4A3 |
| Gene name | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | |
| Synonyms | CD20L|HTM4 | |
| Cytomap | UCSC genome browser: 11q12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031666.1, NM_001031809.1,NM_006138.4, | |
| Description | CD20 antigen homologCD20 antigen-like proteinIgE receptor beta chainIgE receptor beta subunithematopoietic cell 4 transmembrane proteinhematopoietic-specific transmembrane protein 4membrane-spanning 4-domains subfamily A member 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606498 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000149516 | ||
| HPRD : 09403 | ||
| Vega : OTTHUMG00000167380 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MS4A3 | |
| BioGPS: 932 | ||
| Pathway | NCI Pathway Interaction Database: MS4A3 | |
| KEGG: MS4A3 | ||
| REACTOME: MS4A3 | ||
| Pathway Commons: MS4A3 | ||
| Context | iHOP: MS4A3 | |
| ligand binding site mutation search in PubMed: MS4A3 | ||
| UCL Cancer Institute: MS4A3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrow | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAML | |
| Reference showing the relevant tissue of MS4A3 | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MS4A3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.38794327 | 0.689766534 | -1.077709804 | 9.19E-09 | 2.91E-08 |
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| TissGene-miRNA for MS4A3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MS4A3 |
| TissGeneSNV for MS4A3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S208F | SKCM | 2 |
| p.W94* | SKCM | 2 |
| p.S162F | SKCM | 2 |
| p.E5K | SKCM | 1 |
| p.G39L | LUAD | 1 |
| p.T145I | SKCM | 1 |
| p.P36T | LUAD | 1 |
| p.G39* | LUAD | 1 |
| p.S32F | SKCM | 1 |
| p.Q35K | GBM | 1 |
| p.D38Y | UCEC | 1 |
| p.A129D | OV | 1 |
| p.G39V | LUAD | 1 |
| p.G103E | LGG | 1 |
| p.Q44* | BLCA | 1 |
| p.D7H | BLCA | 1 |
| p.P160Q | LUAD | 1 |
| p.Q49H | LIHC | 1 |
| p.I189L | UCEC | 1 |
| p.L65V | COAD | 1 |
| p.Q44H | BLCA | 1 |
| p.C153F | UCEC | 1 |
| p.G110E | SKCM | 1 |
| p.A9G | LUAD | 1 |
| p.P160L | LUSC | 1 |
| p.Q119H | KIRC | 1 |
| p.L141V | LUAD | 1 |
| p.A2P | LUAD | 1 |
| p.M1I | SKCM | 1 |
| p.S168F | GBM | 1 |
| p.V33I | UCEC | 1 |
| p.D42Y | LUSC | 1 |
| p.E159Q | COAD | 1 |
| p.G167V | LUAD | 1 |
| p.P160T | LUAD | 1 |
| p.D38Y | LGG | 1 |
| p.S3F | CESC | 1 |
| p.G103E | SKCM | 1 |
| p.R204T | LUAD | 1 |
| p.H17N | LUAD | 1 |
| p.T191I | SKCM | 1 |
| p.G52_splice | LUSC | 1 |
| p.S106F | LUAD | 1 |
| p.S209T | LUSC | 1 |
| p.T130K | LUAD | 1 |
| p.L185S | UCEC | 1 |
| p.L51V | BLCA | 1 |
| p.P26S | UCEC | 1 |
| p.L180F | PAAD | 1 |
| p.E5K | BLCA | 1 |
| p.E5K | HNSC | 1 |
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| TissGeneCNV for MS4A3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MS4A3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | KIRC | TCGA-B0-4688-01A | ARNT2-MS4A3 | Out-of-frame | Chr15:80873745 | Chr11:59834424 |
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| TissGeneNet for MS4A3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| COAD (tumor) | COAD (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| KICH (tumor) | KICH (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| STAD (tumor) | STAD (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| THCA (tumor) | THCA (normal) |
| MS4A3, CDK2, CDKN3 (tumor) | MS4A3, CDK2, CDKN3 (normal) |
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| TissGeneProg for MS4A3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MS4A3 |
| TissGeneDrug for MS4A3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MS4A3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0043144 | Wheezing | 1 | BeFree |
| umls:C0149782 | Squamous cell carcinoma of lung | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
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