TissGeneSummary for TPTE2 |
Gene summary |
Basic gene information | Gene symbol | TPTE2 |
Gene name | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 | |
Synonyms | TPIP | |
Cytomap | UCSC genome browser: 13q12.11 | |
Type of gene | protein-coding | |
RefGenes | NM_199255.1, NM_001141968.1,NM_001271850.1,NM_130785.3,NM_199254.2, NR_073485.1,NR_073486.1,NR_073487.1, | |
Description | PTEN-like inositol lipid phosphataseTPIP lipid phosphataseTPTE and PTEN homologous inositol lipid phosphataselipid phosphatase TPIPphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE | |
Modification date | 20141207 | |
dbXrefs | MIM : 606791 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132958 | ||
HPRD : 06003 | ||
Vega : OTTHUMG00000016493 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TPTE2 | |
BioGPS: 93492 | ||
Pathway | NCI Pathway Interaction Database: TPTE2 | |
KEGG: TPTE2 | ||
REACTOME: TPTE2 | ||
Pathway Commons: TPTE2 | ||
Context | iHOP: TPTE2 | |
ligand binding site mutation search in PubMed: TPTE2 | ||
UCL Cancer Institute: TPTE2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TPTE2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TPTE2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TPTE2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TPTE2 |
TissGeneSNV for TPTE2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G451S | PCPG | 4 |
p.R258Q | SKCM | 3 |
p.R177* | GBM | 3 |
p.K39E | UVM | 3 |
p.R126* | SKCM | 3 |
p.N447D | MESO | 2 |
p.E9K | SKCM | 2 |
p.E339K | UCEC | 2 |
p.E51G | STAD | 2 |
p.I508M | STAD | 2 |
p.P475S | THYM | 2 |
p.E137K | SKCM | 1 |
p.K39E | PCPG | 1 |
p.S40R | ESCA | 1 |
p.R494K | UCEC | 1 |
p.D162_I163delinsX | COAD | 1 |
p.S22_splice | GBM | 1 |
p.P245S | SKCM | 1 |
p.Y158D | GBM | 1 |
p.E339K | LAML | 1 |
p.M419I | SKCM | 1 |
p.R270S | KIRC | 1 |
p.M41V | READ | 1 |
p.G241E | SKCM | 1 |
p.G352E | SKCM | 1 |
p.K399I | PCPG | 1 |
p.P511S | SKCM | 1 |
p.P234L | SKCM | 1 |
p.T329I | LUAD | 1 |
p.R214K | SKCM | 1 |
p.P292T | LUSC | 1 |
p.L91V | PAAD | 1 |
p.R186I | ESCA | 1 |
p.R262L | KIRC | 1 |
p.S73Y | LUAD | 1 |
p.G451C | THYM | 1 |
p.S4I | UCEC | 1 |
p.P234T | ESCA | 1 |
p.K311N | THCA | 1 |
p.L124V | KIRP | 1 |
p.D215N | SKCM | 1 |
p.K164T | STAD | 1 |
p.D94N | SKCM | 1 |
p.E228K | SKCM | 1 |
p.D273N | SKCM | 1 |
p.E43A | PCPG | 1 |
p.L390V | BLCA | 1 |
p.D104N | SKCM | 1 |
p.L139S | BRCA | 1 |
p.E339K | LUSC | 1 |
p.Q239H | KIRC | 1 |
p.H384N | ACC | 1 |
p.S22_splice | LUSC | 1 |
p.L91F | SKCM | 1 |
p.K144R | LGG | 1 |
p.K507N | UCEC | 1 |
p.Y470* | KIRC | 1 |
p.L224F | SKCM | 1 |
p.G340S | SKCM | 1 |
p.R326K | SKCM | 1 |
p.S240C | LUSC | 1 |
p.R262Q | UCEC | 1 |
p.K64N | PRAD | 1 |
p.P134S | SKCM | 1 |
p.E21K | SKCM | 1 |
p.E521D | LUAD | 1 |
p.I508M | ESCA | 1 |
p.G216R | SKCM | 1 |
p.G451S | CHOL | 1 |
p.E521D | UCEC | 1 |
p.D442N | STAD | 1 |
p.E339K | SKCM | 1 |
p.H278Y | SKCM | 1 |
p.D327Y | COAD | 1 |
p.F300S | PRAD | 1 |
p.I72N | SKCM | 1 |
p.E385K | SKCM | 1 |
p.C209Y | COAD | 1 |
p.F477L | BLCA | 1 |
p.P134Q | COAD | 1 |
p.G431E | SKCM | 1 |
p.R394Q | UCEC | 1 |
p.V291F | UCEC | 1 |
p.N481S | BLCA | 1 |
p.N488K | PAAD | 1 |
p.G451R | LUSC | 1 |
p.G116A | SARC | 1 |
p.P5L | LIHC | 1 |
p.R280M | UCEC | 1 |
p.R243K | SKCM | 1 |
p.R177* | BLCA | 1 |
p.E51G | ESCA | 1 |
p.V154G | STAD | 1 |
p.E496K | SKCM | 1 |
p.R258Q | UCEC | 1 |
p.S72L | SKCM | 1 |
p.D87N | SKCM | 1 |
p.Y449F | KIRC | 1 |
p.R186I | UCEC | 1 |
p.D94N | UCEC | 1 |
p.R109H | BRCA | 1 |
p.Y470X | KIRC | 1 |
p.L92F | SKCM | 1 |
p.E43A | CHOL | 1 |
p.K422N | THCA | 1 |
p.Y108N | LUSC | 1 |
p.S40R | STAD | 1 |
p.E202V | SKCM | 1 |
p.R211Q | GBM | 1 |
p.H384Y | BLCA | 1 |
p.S38R | GBM | 1 |
p.G30R | SKCM | 1 |
p.D162N | SKCM | 1 |
p.S73F | UCEC | 1 |
p.C491F | HNSC | 1 |
p.N481S | LUSC | 1 |
p.L492Q | SKCM | 1 |
p.E257K | SKCM | 1 |
p.R262* | SKCM | 1 |
p.I169V | STAD | 1 |
p.E43A | THCA | 1 |
p.I159S | STAD | 1 |
p.R270K | SKCM | 1 |
p.I63S | LUAD | 1 |
p.E9K | HNSC | 1 |
p.M41V | STAD | 1 |
p.R147Q | SKCM | 1 |
p.V448A | CESC | 1 |
p.M308I | SKCM | 1 |
p.R251Q | STAD | 1 |
p.A344S | LUAD | 1 |
p.E49K | ESCA | 1 |
p.R407C | SKCM | 1 |
p.P400S | SKCM | 1 |
p.L102F | SKCM | 1 |
p.K399I | PAAD | 1 |
p.L219I | LUAD | 1 |
p.K255R | LGG | 1 |
p.R195T | KIRC | 1 |
p.L90F | SKCM | 1 |
p.R180Q | GBM | 1 |
p.G116A | BLCA | 1 |
p.E3G | LGG | 1 |
p.R283I | UCEC | 1 |
p.K255N | PAAD | 1 |
p.E368K | SKCM | 1 |
p.E43A | PRAD | 1 |
p.R159I | COAD | 1 |
p.G377A | ESCA | 1 |
p.I183N | SKCM | 1 |
p.M419L | OV | 1 |
p.E43A | SKCM | 1 |
p.N265K | LUAD | 1 |
p.E43A | LUAD | 1 |
p.E49D | OV | 1 |
p.R103K | SKCM | 1 |
p.R251Q | HNSC | 1 |
p.G211R | SKCM | 1 |
p.R147Q | READ | 1 |
p.E521K | SKCM | 1 |
p.R227L | LUAD | 1 |
p.S405L | SKCM | 1 |
p.P510S | SKCM | 1 |
p.D94A | SARC | 1 |
p.S206L | UCEC | 1 |
p.G377A | THYM | 1 |
p.E43A | STAD | 1 |
p.R126G | BLCA | 1 |
p.R159K | SKCM | 1 |
p.G116A | UCEC | 1 |
p.E207D | PRAD | 1 |
p.L335F | SKCM | 1 |
p.T327S | ESCA | 1 |
p.G451S | UVM | 1 |
p.L120I | LUAD | 1 |
p.E27K | BLCA | 1 |
p.G322R | SKCM | 1 |
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TissGeneCNV for TPTE2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TPTE2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A14P-01A | TPTE2-DNAL4 | CDS-5'UTR | chr13:20066989 | chr22:39178875 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NI-01A | PLA2G6-TPTE2 | In-Frame | chr22:38541444 | chr13:20067641 |
TCGAfusionPortal | PRADA | LUSC | TCGA-60-2720-01A | DNMBP-TPTE2 | 5UTR-CDS | Chr10:101769595 | Chr13:20012293 |
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TissGeneNet for TPTE2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TPTE2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TPTE2 |
TissGeneDrug for TPTE2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TPTE2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023890 | Liver Cirrhosis | 1 | GAD |
umls:C0023903 | Liver neoplasms | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | GAD |