TissGeneSummary for CAPZA3 |
Gene summary |
Basic gene information | Gene symbol | CAPZA3 |
Gene name | capping protein (actin filament) muscle Z-line, alpha 3 | |
Synonyms | CAPPA3|Gsg3 | |
Cytomap | UCSC genome browser: 12p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_033328.2, | |
Description | CP-alpha-3CapZ alpha-3F-actin capping protein alpha-3 subunitF-actin-capping protein subunit alpha-3germ cell-specific protein 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608722 | |
HGNC : HGNC | ||
Ensembl : ENSG00000177938 | ||
HPRD : 12282 | ||
Vega : OTTHUMG00000169001 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAPZA3 | |
BioGPS: 93661 | ||
Pathway | NCI Pathway Interaction Database: CAPZA3 | |
KEGG: CAPZA3 | ||
REACTOME: CAPZA3 | ||
Pathway Commons: CAPZA3 | ||
Context | iHOP: CAPZA3 | |
ligand binding site mutation search in PubMed: CAPZA3 | ||
UCL Cancer Institute: CAPZA3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CAPZA3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CAPZA3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.604103826 | 0.705938279 | -2.310042105 | 4.97E-34 | 8.49E-33 |
KIRC | -2.079235332 | -0.695358943 | -1.383876389 | 2.37E-24 | 2.68E-23 |
KIRP | -2.095339846 | -0.238886721 | -1.856453125 | 9.99E-14 | 1.96E-12 |
ESCA | -1.400575357 | 0.735679188 | -2.136254545 | 0.00567 | 0.042891429 |
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TissGene-miRNA for CAPZA3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CAPZA3 |
TissGeneSNV for CAPZA3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W170* | SKCM | 5 |
p.G136E | SKCM | 5 |
p.W170X | SKCM | 4 |
p.R82Q | SKCM | 3 |
p.E26K | SKCM | 2 |
p.H158Y | SKCM | 2 |
p.D33N | SKCM | 2 |
p.E211K | SKCM | 2 |
p.W174* | SKCM | 2 |
p.P69S | SKCM | 2 |
p.G25E | SKCM | 2 |
p.E214K | SKCM | 2 |
p.R16H | HNSC | 1 |
p.L96M | COAD | 1 |
p.E161K | SKCM | 1 |
p.L117Q | SKCM | 1 |
p.I189L | UCEC | 1 |
p.A193S | CESC | 1 |
p.A222V | LGG | 1 |
p.Q100* | SKCM | 1 |
p.R227K | SKCM | 1 |
p.E12K | SKCM | 1 |
p.L121I | UCEC | 1 |
p.R188G | UCEC | 1 |
p.Q218* | SKCM | 1 |
p.Q237* | SKCM | 1 |
p.E250K | TGCT | 1 |
p.Q100X | SKCM | 1 |
p.L3V | PRAD | 1 |
p.D259Y | LUAD | 1 |
p.S60Y | COAD | 1 |
p.G136A | OV | 1 |
p.R16C | UCEC | 1 |
p.L247* | LUSC | 1 |
p.Q237L | LUAD | 1 |
p.D66N | COAD | 1 |
p.K210R | HNSC | 1 |
p.I288V | LIHC | 1 |
p.G285E | SKCM | 1 |
p.L3I | THCA | 1 |
p.R39H | DLBC | 1 |
p.R13I | PAAD | 1 |
p.R16C | BLCA | 1 |
p.R257* | PRAD | 1 |
p.S212N | SKCM | 1 |
p.I255T | DLBC | 1 |
p.D259N | SKCM | 1 |
p.E211K | PAAD | 1 |
p.L260I | READ | 1 |
p.S60F | SKCM | 1 |
p.L34I | READ | 1 |
p.F92L | CESC | 1 |
p.I152L | SKCM | 1 |
p.L256I | COAD | 1 |
p.R13X | SKCM | 1 |
p.R253K | SKCM | 1 |
p.Q237X | SKCM | 1 |
p.L278Q | KIRP | 1 |
p.M78I | HNSC | 1 |
p.S91A | SKCM | 1 |
p.R82L | PAAD | 1 |
p.L260F | SKCM | 1 |
p.E12* | LUAD | 1 |
p.Q57R | SKCM | 1 |
p.V77I | READ | 1 |
p.R118T | UCEC | 1 |
p.Y128S | KIRP | 1 |
p.L3F | LGG | 1 |
p.L43R | STAD | 1 |
p.R13* | SKCM | 1 |
p.V70L | PAAD | 1 |
p.E250K | PAAD | 1 |
p.N217S | PAAD | 1 |
p.I299M | LUSC | 1 |
p.A30S | LUAD | 1 |
p.W174X | SKCM | 1 |
p.K89N | SARC | 1 |
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TissGeneCNV for CAPZA3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CAPZA3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CAPZA3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CAPZA3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CAPZA3 |
TissGeneDrug for CAPZA3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CAPZA3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |